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    APPARATUS AND METHOD FOR MULTI-MODAL IMAGING USING NANOPARTICLE MULTI-MODAL IMAGING PROBES
    1.
    发明申请
    APPARATUS AND METHOD FOR MULTI-MODAL IMAGING USING NANOPARTICLE MULTI-MODAL IMAGING PROBES 审中-公开
    使用纳米尺度多模式成像探针进行多模式成像的装置和方法

    公开(公告)号：US20090086908A1

    公开(公告)日：2009-04-02

    申请号：US12196300

    申请日：2008-08-22

    申请人： John William Harder ,  David L. Patton ,  Shiying Zheng ,  Ruizheng Wang ,  Joseph Francis Bringley ,  Douglas Lincoln Vizard ,  William E. McLaughlin ,  Heidi Hall ,  Mark E. Bridges

    发明人： John William Harder ,  David L. Patton ,  Shiying Zheng ,  Ruizheng Wang ,  Joseph Francis Bringley ,  Douglas Lincoln Vizard ,  William E. McLaughlin ,  Heidi Hall ,  Mark E. Bridges

    IPC分类号： G01N23/04 ,  G03B42/02

    CPC分类号： A61B6/00 ,  A61B5/0035 ,  A61B5/0059 ,  A61B6/4216 ,  A61B6/4417 ,  A61B6/481 ,  A61B6/508 ,  A61B2503/40 ,  A61B2562/0242

    摘要： An apparatus for multimodal imaging of an object includes a support stage for receiving an object to be imaged; an object supported on the stage, the object having been treated with a biocompatible imaging probe comprising nanoparticles carrying one or more targeting moieties and one or more diagnostic components for enabling capture of images of the object; a light source for producing a beam to illuminate the object; a filter positioned to receive and pass the beam toward the object; and a lens and camera system for capturing an image of the object. The apparatus may include a tiltable filter for filtering light from the source. The apparatus may include a mechanism for selectively directing light from the light source through a first filter assembly to produce a first beam of light of a first frequency range for illuminating an object on the stage in a first imaging mode or through a second filter assembly to produce a second beam of light of a second frequency range for illuminating an object on the stage in a second imaging mode, so that the lens and camera system captures light from the object illuminated by either the first or second beam of light to produce a first image in response to the first beam and a second image, different from the first image, in response to the second image. An x-ray source and phosphor plate may be included to provide an additional imaging mode.

    摘要翻译： 用于物体的多模式成像的装置包括用于接收待成像对象的支撑台; 支撑在舞台上的物体，已经用生物相容性成像探针处理了物体，所述生物相容性成像探针包含携带一个或多个靶向部分的纳米颗粒和一个或多个诊断部件，用于能够捕获物体的图像; 用于产生用于照射物体的光束的光源; 定位成接收并将光束传递到物体的过滤器; 以及用于捕获对象的图像的镜头和相机系统。 该装置可以包括用于过滤来自源的光的可倾斜滤光器。 该装置可以包括用于选择性地引导来自光源的光通过第一滤光器组件以产生第一频率范围的第一光束的机构，用于以第一成像模式照射舞台上的物体或通过第二滤光器组件 产生第二频率范围的第二光束，用于在第二成像模式下照射舞台上的物体，使得透镜和照相机系统捕获来自被第一或第二光束照射的物体的光，以产生第一 响应于第一光束的图像和与第一图像不同的第二图像。 可以包括x射线源和磷光体板以提供附加的成像模式。

    IMAGING CONTRAST AGENTS USING NANOPARTICLES
    3.
    发明申请
    IMAGING CONTRAST AGENTS USING NANOPARTICLES 审中-公开
    使用纳米颗粒成像对比剂

    公开(公告)号：US20080095699A1

    公开(公告)日：2008-04-24

    申请号：US11738558

    申请日：2007-04-23

    申请人： Shiying Zheng ,  Ruizheng Wang ,  Wenyi Che

    发明人： Shiying Zheng ,  Ruizheng Wang ,  Wenyi Che

    IPC分类号： A61K49/00 ,  A61K39/395 ,  A61K49/06 ,  A61K49/18 ,  A61K51/12 ,  A61K9/14

    CPC分类号： A61K49/0093 ,  A61K49/0032 ,  A61K49/1881

    摘要： The present invention relates to a nanoparticle comprising self-assembled crosslinked, amphiphilic block copolymers and at least one immobilized dye, wherein the self-assembled, crosslinked, amphiphilic block copolymers comprise a hydrophilic block and a hydrophobic block, wherein the self-assembled, crosslinked, amphiphilic block copolymers are self-assembled to form a core of the nanoparticle comprising a hydrophobic block, wherein the hydrophobic block is derived from at least one pendant multifunctional crosslinked alkoxy silane or amino silane moiety, and an exterior of the nanoparticle comprising a hydrophilic block, and wherein the immobilized dye is immobilized in the core.

    摘要翻译： 本发明涉及包含自组装的交联的两亲性嵌段共聚物和至少一种固定化染料的纳米颗粒，其中所述自组装的交联的两亲性嵌段共聚物包含亲水嵌段和疏水嵌段，其中所述自组装交联 两亲性嵌段共聚物自组装形成包含疏水嵌段的纳米颗粒的核心，其中所述疏水嵌段衍生自至少一个侧链多官能交联的烷氧基硅烷或氨基硅烷部分，并且所述纳米颗粒的外部包含亲水嵌段 ，并且其中固定的染料固定在芯中。

    SILICA-CORED CARRIER PARTICLE
    5.
    发明申请
    SILICA-CORED CARRIER PARTICLE 审中-公开
    二氧化硅载体颗粒

    公开(公告)号：US20090169482A1

    公开(公告)日：2009-07-02

    申请号：US11930417

    申请日：2007-10-31

    申请人： Shiying Zheng ,  Lijun Dai ,  Ruizheng Wang ,  Tiecheng A. Qiao ,  Wenyi Che ,  William J. Harrison

    发明人： Shiying Zheng ,  Lijun Dai ,  Ruizheng Wang ,  Tiecheng A. Qiao ,  Wenyi Che ,  William J. Harrison

    IPC分类号： A61K49/00

    CPC分类号： A61K49/0032 ,  A61K49/0056 ,  A61K49/0093

    摘要： A nanoparticulate imaging probe with an oxide core, a biocompatible polymeric shell covalently attached to the oxide core, a dye, and a cleavable spacer that covalently binds the dye to the probe. When the spacer is cleaved, the dye is liberated from the probe. The emissions of the dye are quenched when the dye is bound to the probe and not quenched when the dye is liberated from the probe. The spacer can be, for example, a peptide. The oxide core can be, for example, a silicon oxide core.

    摘要翻译： 具有氧化物核心，共价连接到氧化物核心的生物相容性聚合物外壳的纳米颗粒成像探针，染料和将染料共价结合到探针上的可切割间隔物。 当间隔物被切割时，染料从探针中释放出来。 当染料与探针结合时，染料的排放物被淬灭，当染料从探针中释放出来时，染料的发射不被淬灭。 间隔物可以是例如肽。 氧化物核可以是例如氧化硅芯。

    Inkjet printing method
    7.
    发明授权
    Inkjet printing method 有权
    喷墨打印方式

    公开(公告)号：US07077516B2

    公开(公告)日：2006-07-18

    申请号：US10397699

    申请日：2003-03-26

    申请人： Huijuan D. Chen ,  Shiying Zheng ,  Ricky G. Frazier

    发明人： Huijuan D. Chen ,  Shiying Zheng ,  Ricky G. Frazier

    IPC分类号： B41J2/01

    CPC分类号： B41M5/0023 ,  B41M5/0058 ,  B41M5/508 ,  B41M7/009 ,  C09D11/322

    摘要： An ink jet printing method, including the steps of: A) providing an ink jet printer that is responsive to digital data signals; B) loading said printer with an ink jet recording element, having a non-absorbing substrate; C) loading said printer with an ink jet ink composition having an aqueous ink jet ink composition comprising: a pigment; a heat sensitive ionomer; at least one surfactant; and a humectant; wherein the ionomer is a charged polymer having at least 5 mol % of the recurring units negatively or positively charged, and D) printing on said ink jet recording element accompanied by a heating step using said ink jet ink composition in response to said digital data signals.

    摘要翻译： 一种喷墨打印方法，包括以下步骤：A）提供响应于数字数据信号的喷墨打印机; B）用具有非吸收性基材的喷墨记录元件装载所述打印机; C）用具有水性喷墨油墨组合物的喷墨油墨组合物装载所述打印机，所述喷墨油墨组合物包含：颜料; 热敏离子交联剂; 至少一种表面活性剂; 和湿润剂; 其中所述离聚物是具有至少5摩尔％重复单元带负电或带正电荷的带电聚合物，以及D）响应于所述数字数据信号，使用所述喷墨油墨组合物伴随加热步骤在所述喷墨记录元件上印刷 。

    Electroluminescent device with polyphenyl hydrocarbon hole transport layer
    9.
    发明授权
    Electroluminescent device with polyphenyl hydrocarbon hole transport layer 有权
    具有聚苯烃空穴传输层的电致发光器件

    公开(公告)号：US06596415B2

    公开(公告)日：2003-07-22

    申请号：US09842445

    申请日：2001-04-26

    申请人： Jianmin Shi ,  Shiying Zheng ,  Ching W. Tang

    发明人： Jianmin Shi ,  Shiying Zheng ,  Ching W. Tang

    IPC分类号： H05B3312

    CPC分类号： H01L51/5012 ,  H01L51/005 ,  H01L51/0054 ,  H01L51/0055 ,  H01L51/0058 ,  H01L51/0059 ,  H01L51/0071 ,  Y10S428/917

    摘要： An organic multilayer electroluminescent device including an anode and cathode, and comprising therebetween: a hole transport layer; and an electron transport layer disposed in operative relationship with the hole transport layer; wherein: the hole transport layer includes an organic compound having the formula: wherein: Ar is an aryl moiety; n is an integer of from 1 to 6; and substituents R1 and R2 are each individually hydrogen, or alkyl of from 1 to 24 carbon atoms; aryl or substituted aryl of from 5 to 28 carbon atoms; or heteroaryl or substituted heteroaryl of from 5 to 28 carbon atoms; or fluorine, chlorine, bromine; or cyano group.

    摘要翻译： 一种包括阳极和阴极的有机多层电致发光器件，包括：空穴传输层; 和电子传输层，其与空穴传输层具有可操作的关系;其中：所述空穴传输层包括具有下式的有机化合物：其中：Ar是芳基部分; n是1至6的整数; 取代基R 1和R 2各自独立地为氢或1至24个碳原子的烷基; 具有5至28个碳原子的芳基或取代的芳基; 或具有5至28个碳原子的杂芳基或取代的杂芳基; 或氟，氯，溴; 或氰基。

    Complex oxonol infrared radiation sensitive compounds
    10.
    发明授权
    Complex oxonol infrared radiation sensitive compounds 失效
    复合氧化物红外辐射敏感化合物

    公开(公告)号：US06538140B1

    公开(公告)日：2003-03-25

    申请号：US09946420

    申请日：2001-09-05

    申请人： Kevin W. Williams ,  Shiying Zheng

    发明人： Kevin W. Williams ,  Shiying Zheng

    IPC分类号： C07D4110

    CPC分类号： B41M5/465 ,  B41C1/1033 ,  C09B23/0075 ,  G03C1/832 ,  G03C5/164

    摘要： Infrared radiation-sensitive compounds have been found that are represented by Structure DYE as follows: wherein R is a substituted or unsubstituted alkyl group, substituted or unsubstituted cycloalkyl group, substituted or unsubstituted heterocyclic group, or substituted or unsubstituted carbocyclic aromatic group, R1 and R1 are independently substituted or unsubstituted heterocyclic or carbocyclic aromatic groups, and M+ is a monovalent cation. These compounds have a &lgr;max above 700 nm and are can be used in a number of photosensitive or heat-sensitive imaging materials.

    摘要翻译： 已经发现由结构DYE表示的红外辐射敏感化合物如下：其中R是取代或未取代的烷基，取代或未取代的环烷基，取代或未取代的杂环基或取代或未取代的碳环芳基，R 1和R 1 独立地为取代或未取代的杂环或碳环芳基，M +为单价阳离子。 这些化合物的lambdmax高于700nm，可用于许多感光或热敏成像材料。