公开(公告)号：US20060058277A1

公开(公告)日：2006-03-16

申请号：US11250262

申请日：2005-10-14

申请人： John Yanni ,  Daniel Gamache ,  Steven Miller ,  Ernesto Castillo

发明人： John Yanni ,  Daniel Gamache ,  Steven Miller ,  Ernesto Castillo

IPC分类号： A61K31/573

CPC分类号： A61K31/575 ,  A61K9/0048 ,  A61K31/57 ,  A61K31/573 ,  A61K47/12 ,  A61K47/18 ,  A61K47/186 ,  A61K47/26 ,  A61K47/32

摘要： Topical ophthalmic compositions and methods for treating dry eye are described. The compositions and methods of the invention are based on the finding that the oculosurface selective properties of the glucocorticoid rimexolone make this anti-inflammatory agent particularly well-suited for treating dry eye. As a result of the limited ability of rimexolone to penetrate the cornea, a high portion of the drug remains on the surface of the eye, which is the primary locus of the inflammatory conditions associated with dry eye. This enables a very low concentration of drug to be utilized, which in turn reduces the potential for elevations of intraocular pressure and cataract formation.

摘要翻译： 描述了用于治疗干眼症的局部眼用组合物和方法。 本发明的组合物和方法基于这样的发现，即糖皮质激素瑞ol酮的眼部表面选择性使该抗炎剂特别适合于治疗干眼症。 由于赖ol酮渗透角膜的能力有限，药物的大部分残留在眼睛的表面上，这是与干眼症相关的炎性病症的主要位点。 这使得能够使用非常低浓度的药物，这又降低了眼压升高和白内障形成的可能性。

公开(公告)号：US20080096852A1

公开(公告)日：2008-04-24

申请号：US11925178

申请日：2007-10-26

申请人： John YANNI ,  Daniel Gamache ,  Steven Miller ,  Ernesto Castillo

发明人： John YANNI ,  Daniel Gamache ,  Steven Miller ,  Ernesto Castillo

IPC分类号： A61K31/575 ,  A61P27/02

CPC分类号： A61K31/575 ,  A61K9/0048 ,  A61K31/57 ,  A61K31/573 ,  A61K47/12 ,  A61K47/18 ,  A61K47/186 ,  A61K47/26 ,  A61K47/32

摘要： Topical ophthalmic compositions and methods for treating dry eye are described. The compositions and methods of the invention are based on the finding that the oculosurface selective properties of the glucocorticoid rimexolone make this anti-inflammatory agent particularly well-suited for treating dry eye. As a result of the limited ability of rimexolone to penetrate the cornea, a high portion of the drug remains on the surface of the eye, which is the primary locus of the inflammatory conditions associated with dry eye. This enables a very low concentration of drug to be utilized, which in turn reduces the potential for elevations of intraocular pressure and cataract formation.

摘要翻译： 描述了用于治疗干眼症的局部眼用组合物和方法。 本发明的组合物和方法基于这样的发现，即糖皮质激素瑞ol酮的眼部表面选择性使该抗炎剂特别适合于治疗干眼症。 由于赖ol酮渗透角膜的能力有限，药物的大部分残留在眼睛的表面上，这是与干眼症相关的炎性病症的主要位点。 这使得能够使用非常低浓度的药物，这又降低了眼压升高和白内障形成的可能性。

公开(公告)号：US20060217325A1

公开(公告)日：2006-09-28

申请号：US10539093

申请日：2003-10-17

申请人： John Yanni ,  Daniel Gamache ,  Steven Miller

发明人： John Yanni ,  Daniel Gamache ,  Steven Miller

IPC分类号： A61K48/00

CPC分类号： A61K48/005 ,  A61K38/44 ,  A61K48/00 ,  A61K48/0075 ,  C12Y113/11031

摘要： The present invention provides compositions comprising the 15-lipoxygenase-1 (15-LO-1) or 15-lipoxyngenase-2 (15-LO-2) gene such that 15-LO-1 or 15-LO-2 protein expression is replaced or replenished in the ocular surface epithelium of post-menopausal women suffering from dry eye. Thus, methods for treatment of dry eye in postmenopausal women are further provided.

摘要翻译： 本发明提供包含15-脂肪氧合酶-1（15-LO-1）或15-脂肪氧合酶-2（15-LO-2）基因的组合物，使得15-LO-1或15-LO-2蛋白质表达被替换 或补充在患有干眼症的绝经后妇女的眼表上皮中。 因此，进一步提供了在绝经后妇女中治疗干眼症的方法。

公开(公告)号：US20070281901A1

公开(公告)日：2007-12-06

申请号：US11750262

申请日：2007-05-17

申请人： John Yanni ,  Jon Chatterton ,  Diane Senchyna ,  Daniel Gamache ,  Steven Miller

发明人： John Yanni ,  Jon Chatterton ,  Diane Senchyna ,  Daniel Gamache ,  Steven Miller

IPC分类号： A61K48/00

CPC分类号： C12N15/1138 ,  A61K31/7088 ,  A61K31/713 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/30

摘要： RNA interference is provided for inhibition of tumor necrosis factor α (TNFα) by silencing TNFα cell surface receptor TNF receptor-1 (TNFR1) mRNA expression, or by silencing TNFα converting enzyme (TACE/ADAM17) mRNA expression. Silencing such TNFα targets, in particular, is useful for treating patients having a TNFα-related condition or at risk of developing a TNFα-related condition such as the ocular conditions dry eye, allergic conjunctivitis, or ocular inflammation, or such as dermatitis, rhinitis, or asthma, for example.

摘要翻译： 通过沉默TNFα细胞表面受体TNF受体-1（TNFR1）mRNA表达或沉默TNFα转化酶（TACE / ADAM17）mRNA表达，提供RNA干扰抑制肿瘤坏死因子α（TNFalpha）。 特别是沉默这种TNFα靶标，可用于治疗患有TNFalpha相关病症或有发生TNFalpha相关病症风险的患者，如眼病干眼症，过敏性结膜炎或眼部炎症，或皮炎，鼻炎 ，或哮喘。

公开(公告)号：US11142950B2

公开(公告)日：2021-10-12

申请号：US16263796

申请日：2019-01-31

申请人： Steven Miller

发明人： Steven Miller

IPC分类号： E06C7/16 ,  E06C1/39

摘要： A removably attachable platform device for use with a ladder includes a base plate, a coupler, and a pair of fasteners. The coupler is coupled to a lower face of the base plate and is configured to removably couple to a respective rung of a ladder to couple the base plate to the rung. Each fastener is coupled to a respective opposing side edge of the base plate and is configured to removably couple to a respective siderail of the ladder to couple the base plate to the siderails of the ladder. The base plate is positioned substantially parallel to a substantially horizontal surface, upon which the ladder is positioned, and thus is configured to support a user.

公开(公告)号：US09809280B2

公开(公告)日：2017-11-07

申请号：US14946446

申请日：2015-11-19

申请人： Steven Miller ,  Timo Pascal Kommerling

发明人： Steven Miller ,  Timo Pascal Kommerling

IPC分类号： B63B21/20 ,  B63B9/00 ,  B63B59/02

CPC分类号： B63B21/20 ,  B63B9/00 ,  B63B21/045 ,  B63B59/02

摘要： A cleat having an adjustable anchoring system configured to suspend a bumper. The cleat has a first horn located opposite a second horn. A support structure is connected to the cleat. A recess of the support structure has a ridge protruding from a wall surface of the recess. The ridge is configured to deform a portion of rope. A bore of the support structure is configured to receive a fastener. A base has a bore configured to receive the fastener. The bore of the support structure is oriented to align with the bore of the base. The base has two ramps that protrude from a wall surface of a recess of the base. The two ramps form a pocket that can have a protrusion configured to bind a portion of the rope when the fastener is tightened.

公开(公告)号：US20150055977A1

公开(公告)日：2015-02-26

申请号：US14473534

申请日：2014-08-29

申请人： Steven Miller

发明人： Steven Miller

IPC分类号： G03G21/16

CPC分类号： G03G21/1647 ,  G03G15/0844 ,  G03G21/12 ,  Y10T74/1598

摘要： An improved drive system for transmitting rotational force between an imaging machine and an imaging cartridge. A first coupling member comprises a first mating structure configured to transfer or receive rotational force, and a second coupling member comprises a second mating structure configured to transfer or receive rotational force. The first coupling member comprising a locating cone in the center of said first coupling member, said locating cone adapted to locate in an opening of the second coupling member whereby the first coupling member is centered in relation to the second coupling member, and the first mating structure of the first coupling member is directed into contact with the second mating structure of the second coupling member.

摘要翻译： 一种用于在成像机和成像盒之间传递旋转力的改进的驱动系统。 第一联接构件包括构造成传递或接收旋转力的第一配合结构，并且第二联接构件包括构造成传递或接收旋转力的第二配合结构。 第一联接构件包括在所述第一联接构件的中心的定位锥体，所述定位锥体适于定位在第二联接构件的开口中，由此第一联接构件相对于第二联接构件居中，并且第一配合 第一联接构件的结构被引导与第二联接构件的第二配合结构接触。

公开(公告)号：US20140085662A1

公开(公告)日：2014-03-27

申请号：US13624405

申请日：2012-09-21

申请人： Steven Miller ,  Herman Schnell

发明人： Steven Miller ,  Herman Schnell

IPC分类号： G06K15/00

CPC分类号： B41J29/00 ,  B41J29/38 ,  B41J2029/3932 ,  G06K15/407

摘要： An electronic circuit for use with a consumable imaging unit transforms the electronic circuit from a communicated state to a non communicated state, and also induces an imaging machine to read the electronic circuit's transformed information and then store the information in the imaging machine's memory. Additionally, the information of the circuit is configured to alter an identifier of the circuit. The information of the circuit is also configured to point an imaging machine to communicate with a second element of the circuit after the information determines that a first element of the circuit has been altered from its original state.

摘要翻译： 用于消耗成像单元的电子电路将电子电路从通信状态转换为非通信状态，并且还引起成像机读取电子电路的变换信息，然后将信息存储在成像机的存储器中。 此外，电路的信息被配置为改变电路的标识符。 电路的信息还被配置为在信息确定电路的第一元件已经从其原始状态改变之后，将成像机指向与电路的第二元件通信。

公开(公告)号：US20130224271A1

公开(公告)日：2013-08-29

申请号：US13884030

申请日：2010-11-08

申请人： Steven Miller ,  Guofeng Xu ,  Lin Fei ,  Ying Yang

发明人： Steven Miller ,  Guofeng Xu ,  Lin Fei ,  Ying Yang

IPC分类号： A61K8/11

CPC分类号： A61K8/11 ,  A61K8/0275 ,  A61K8/27 ,  A61K8/4993 ,  A61K8/731 ,  A61K8/86 ,  A61K2800/412 ,  A61Q11/00

摘要： The invention relates to a composite and oral care compositions for use in the mouth to retard the accumulation of dental plaque and/or calculus. The composite is a microaggregate comprising polymer coated, surfactant stabilized particles of a substantially insoluble metal, metal salt or metal oxide, for example zinc oxide. Also methods for retarding the accumulation of dental plaque and/or calculus are provided.

摘要翻译： 本发明涉及一种用于口腔的复合和口腔护理组合物，以阻止牙菌斑和/或结石的积聚。 该复合物是包含聚合物涂覆的表面活性剂稳定的基本上不溶的金属，金属盐或金属氧化物的颗粒，例如氧化锌的微团聚物。 还提供了用于延缓牙斑和/或结石积聚的方法。

公开(公告)号：US08474387B2

公开(公告)日：2013-07-02

申请号：US12480320

申请日：2009-06-08

申请人： Steven Miller

发明人： Steven Miller

IPC分类号： F23G5/16 ,  F23G5/20 ,  F23G7/00 ,  C04B11/036 ,  C04B7/44

CPC分类号： F23G5/006 ,  F23G5/008 ,  F23G5/16 ,  F23G5/20 ,  F23G5/24 ,  F23G5/46 ,  F23G5/50 ,  F23G7/001 ,  F23G7/006 ,  F23G2206/201 ,  F23G2209/20 ,  F23G2209/28 ,  F23G2209/281 ,  Y02E20/363

摘要： A method and apparatus for incinerating different types of combustible waste in a cement manufacturing process. Two combustion chambers for incinerating waste are arranged in series, with first combustion chamber being a down draft chamber in which there is a downward flow of combustion gas and waste fuel to a waste and gas outlet. The second chamber is adaptable to support waste on a supporting surface incorporated in the compartment, wherein the waste is transported through the compartment from a waste inlet to a waste outlet along a circular path.

摘要翻译： 一种用于在水泥制造过程中焚烧不同类型的可燃废物的方法和装置。 用于焚烧废物的两个燃烧室被串联布置，其中第一燃烧室是下进气室，其中存在燃烧气体和废燃料向废气和气体出口的向下流动。 第二室适用于在结合在隔室中的支撑表面上支撑废物，其中废物沿着圆形路径从废物入口输送到废物出口。