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公开(公告)号:US11493668B2
公开(公告)日:2022-11-08
申请号:US16548204
申请日:2019-08-22
IPC分类号: G02B1/04 , C07C225/00 , C08L51/08 , C08L83/10 , C07D311/22 , C08F220/28 , G02C7/10 , A61F2/16 , A61F2/14 , G02C7/04 , C08F290/06 , C08F283/12
摘要: Described are polymerizable high energy light absorbing compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and X are as described herein. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.
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公开(公告)号:US11021558B2
公开(公告)日:2021-06-01
申请号:US15656033
申请日:2017-07-21
发明人: Brian Aitken , Charles Scales , Scott Joslin , Yong Zhang , Dola Sinha , Shivkumar Mahadevan , Patricia Martin , Fang Lu , Donnie Duis , Stephen C. Arnold
IPC分类号: C08F290/06 , C08J7/16 , C08F283/12 , C08L51/08 , C09B69/10 , G02B1/04
摘要: Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator, (c) combining the crosslinked substrate network with a second reactive composition containing one or more ethylenically unsaturated compounds; and (d) activating the covalently bound activatable free radical initiator of the crosslinked substrate network such that the second reactive composition polymerizes therein with the crosslinked substrate network to form a grafted polymeric network and a byproduct polymer. Also provided are precursors to the polymer compositions, processes for preparation of the polymer compositions, and methods of using the polymer compositions, for instance in medical devices.
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公开(公告)号:US20210179766A1
公开(公告)日:2021-06-17
申请号:US17184716
申请日:2021-02-25
发明人: Brian Aitken , Charles Scales , Scott Joslin , Yong Zhang , Dola Sinha , Shivkumar Mahadevan , Patricia Martin , Fang Lu , Donnie Duis , Stephen C. Arnold
IPC分类号: C08G18/61 , G02B1/04 , C08G18/04 , C08K5/53 , C08G18/62 , B29D11/00 , C08L51/08 , G02C7/04 , C08F290/06
摘要: Provided are ophthalmic devices comprised of a reaction product of a composition comprising: (i) a crosslinked substrate network containing covalently bound activatable free radical initiators; and (ii) a grafting composition containing one or more ethylenically unsaturated compounds. Also provided are processes for making ophthalmic devices.
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公开(公告)号:US20200002267A1
公开(公告)日:2020-01-02
申请号:US16398722
申请日:2019-04-30
发明人: Ghulam Maharvi , Shivkumar Mahadevan , Stephen C. Arnold , Patricia Martin , Leilani K. Sonoda , Dola Sinha
IPC分类号: C07C69/738 , C07C233/42 , C08L83/04 , C08K5/20 , C08K5/18 , G02B1/04
摘要: Described are polymerizable high energy light absorbing compounds of formula I: Wherein Y, Pg, R1, R2, R3, R4, R5, and R6 are as described herein. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.
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公开(公告)号:US20210261712A1
公开(公告)日:2021-08-26
申请号:US17242948
申请日:2021-04-28
发明人: Brian Aitken , Charles Scales , Scott Joslin , Yong Zhang , Dola Sinha , Shivkumar Mahadevan , Patricia Martin , Fang Lu , Donnie Duis , Stephen C. Arnold
IPC分类号: C08F290/06 , C08J7/16 , C08F283/12 , C08L51/08 , C09B69/10 , G02B1/04
摘要: Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator, (c) combining the crosslinked substrate network with a second reactive composition containing one or more ethylenically unsaturated compounds; and (d) activating the covalently bound activatable free radical initiator of the crosslinked substrate network such that the second reactive composition polymerizes therein with the crosslinked substrate network to form a grafted polymeric network and a byproduct polymer. Also provided are precursors to the polymer compositions, processes for preparation of the polymer compositions, and methods of using the polymer compositions, for instance in medical devices.
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公开(公告)号:US11046636B2
公开(公告)日:2021-06-29
申请号:US16398722
申请日:2019-04-30
发明人: Ghulam Maharvi , Shivkumar Mahadevan , Stephen C. Arnold , Patricia Martin , Leilani K. Sonoda , Dola Sinha
IPC分类号: C07C69/738 , C07C225/22 , C07C233/38 , C07C233/42 , G02B1/04 , C08K5/18 , C08K5/20 , C08L83/04
摘要: Described are polymerizable high energy light absorbing compounds of formula I: Wherein Y, Pg, R1, R2, R3, R4, R5, and R6 are as described herein. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.
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公开(公告)号:US20200095187A1
公开(公告)日:2020-03-26
申请号:US16548204
申请日:2019-08-22
IPC分类号: C07C225/00 , C08L51/08 , C08L83/10 , C07D311/22 , C08F220/28 , G02C7/04 , G02C7/10 , A61F2/16 , A61F2/14
摘要: Described are polymerizable high energy light absorbing compounds of formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and X are as described herein. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.
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8.
公开(公告)号:US20190233572A1
公开(公告)日:2019-08-01
申请号:US16239595
申请日:2019-01-04
发明人: Brian Aitken , Charles Scales , Scott Joslin , Yong Zhang , Dola Sinha , Shivkumar Mahadevan , Patricia Martin , Fang Lu , Donnie Duis , Stephen C. Arnold
CPC分类号: C08G18/61 , C08G18/04 , C08G18/6225 , C08G2270/00 , C08K5/53 , G02B1/043
摘要: Provided are ophthalmic devices comprised of a reaction product of a composition comprising: (i) a crosslinked substrate network containing covalently bound activatable free radical initiators; and (ii) a grafting composition containing one or more ethylenically unsaturated compounds. Also provided are processes for making ophthalmic devices.
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9.
公开(公告)号:US20180037690A1
公开(公告)日:2018-02-08
申请号:US15656033
申请日:2017-07-21
发明人: Brian Aitken , Charles Scales , Scott Joslin , Yong Zhang , Dola Sinha , Shivkumar Mahadevan , Patricia Martin , Fang Lu , Donnie Duis , Stephen C. Arnold
IPC分类号: C08F290/06 , C09B69/10 , G02B1/04 , C08L51/08
CPC分类号: C08F290/068 , C08F283/124 , C08J7/16 , C08L51/085 , C08L2201/50 , C08L2203/02 , C09B69/109 , G02B1/043 , C08F220/28 , C08F220/54 , C08F226/10 , C08F220/10 , C08F222/10
摘要: Provided are polymer compositions made by a process comprising: (a) providing a first reactive composition containing: (i) a polymerization initiator that is capable, upon a first activation, of forming two or more free radical groups, at least one of which is further activatable by subsequent activation; (ii) one or more ethylenically unsaturated compounds; and (iii) a crosslinker; (b) subjecting the first reactive composition to a first activation step such that the first reactive composition polymerizes therein to form a crosslinked substrate network containing a covalently bound activatable free radical initiator, (c) combining the crosslinked substrate network with a second reactive composition containing one or more ethylenically unsaturated compounds; and (d) activating the covalently bound activatable free radical initiator of the crosslinked substrate network such that the second reactive composition polymerizes therein with the crosslinked substrate network to form a grafted polymeric network and a byproduct polymer. Also provided are precursors to the polymer compositions, processes for preparation of the polymer compositions, and methods of using the polymer compositions, for instance in medical devices.
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公开(公告)号:US20210309600A1
公开(公告)日:2021-10-07
申请号:US17332416
申请日:2021-05-27
发明人: Ghulam Maharvi , Shivkumar Mahadevan , Stephen C. Arnold , Patricia Martin , Leilani K. Sonoda , Dola Sinha
IPC分类号: C07C69/738 , C07C233/42 , C08K5/18 , C08K5/20 , C08L83/04 , G02B1/04 , C07C225/22 , C07C233/38
摘要: Described are polymerizable high energy light absorbing compounds of formula I: Wherein Y, Pg, R2, R3, R4, R5, and R6 are as described herein. The compounds absorb various wavelengths of ultraviolet and/or high energy visible light and are suitable for incorporation in various products, such as biomedical devices and ophthalmic devices.
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