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1.发明授权Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein 失效用与两亲化合物和DNA结合蛋白质混合的多核苷酸转染细胞的方法公开(公告)号：US06180784B2
公开(公告)日：2001-01-30
申请号：US09020566
申请日：1998-01-17
IPC分类号： C07D25502
CPC分类号： C12N15/87
摘要： The present invention provides a process of transfecting a cell with a polynucleotide mixed with one or more amphipathic compounds and an effective amount of a DNA-binding protein. Exemplary and preferred DNA-binding proteins are H1, H2A, and H2B. Exemplary and preferred amphipathic compounds are cationic amphipathic compounds.
摘要翻译： 本发明提供了用与一种或多种两亲化合物和有效量的DNA结合蛋白混合的多核苷酸转染细胞的方法。 示例性和优选的DNA结合蛋白是H1，H2A和H2B。 示例性和优选的两亲性化合物是阳离子两亲性化合物。
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2.发明授权Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein 失效用与两亲化合物和DNA结合蛋白质混合的多核苷酸转染细胞的方法
公开(公告)号：US5744335A
公开(公告)日：1998-04-28
申请号：US530598
申请日：1995-09-19
申请人： Jon A. Wolff , Jeffery Fritz , Vladimir Budker , James Hagstrom
发明人： Jon A. Wolff , Jeffery Fritz , Vladimir Budker , James Hagstrom
CPC分类号： C12N15/87
摘要： The present invention provides a process of transfecting a cell with a polynucleotide mixed with one or more amphipathic compounds and an effective amount of a DNA-binding protein. Exemplary and preferred DNA-binding proteins are H1, H2A, and H2B. Exemplary and preferred amphipathic compounds are cationic amphipathic compounds.
摘要翻译： 本发明提供了用与一种或多种两亲化合物和有效量的DNA结合蛋白混合的多核苷酸转染细胞的方法。 示例性和优选的DNA结合蛋白是H1，H2A和H2B。 示例性和优选的两亲性化合物是阳离子两亲性化合物。
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