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1.
公开(公告)号:US06265387B1
公开(公告)日:2001-07-24
申请号:US08975573
申请日:1997-11-21
IPC分类号: A61K3500
CPC分类号: A61K48/00 , A61K48/0008
摘要: A process for delivering a polynucleotide to a parenchymal cell in a mammal by injecting the polynucleotide into a blood vessel connected to the parenchymal cell in tissue or organ of the mammal such that the polynucleotide is transfected into the parenchymal cell and functionally expressed to therapeutic levels.
摘要翻译: 将多核苷酸通过将多核苷酸注射到与哺乳动物的组织或器官中的实质细胞连接的血管中将多核苷酸递送至实质细胞的方法,使得多核苷酸被转染到实质细胞中并在功能上表达为治疗水平。
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公开(公告)号:US5762927A
公开(公告)日:1998-06-09
申请号:US827772
申请日:1997-04-11
CPC分类号: C07K16/2809 , A61K38/164 , A61K39/39541 , A61K47/48238 , A61K47/48484 , A61K47/48561 , C07K14/34 , C07K2319/00
摘要: Disclosed is a method of inhibiting a rejection response by a primate to a transplanted organ. One exposes the primate to a mutant diphtheria toxin linked to anti-CD3 antibody so as to largely eliminate the host's peripheral blood T cell lymphocyte population. At the same time as, or after, the exposure step one administers to the primate's thymus gland donor lymphocytes. Transplantation of the organ follows. The primate is tolerized to the transplanted organ.
摘要翻译: 公开了一种抑制灵长类动物对移植器官的排斥反应的方法。 将灵长类动物暴露于与抗CD3抗体连接的突变白喉毒素,从而大大消除宿主的外周血T细胞淋巴细胞群体。 在同一时间或之后,暴露步骤一个施用于灵长类动物的胸腺供体淋巴细胞。 随机移植器官。 灵长类动物容忍移植器官。
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公开(公告)号:US6150121A
公开(公告)日:2000-11-21
申请号:US250679
申请日:1999-02-16
CPC分类号: G01N33/5091 , G01N2333/495 , G01N2333/52 , G01N2333/5406 , G01N2333/55
摘要: Disclosed herein are methods for monitoring the immunological status of transplant recipients. Fibroblast cells derived from transplanted organs are used in proliferation assays with lymphocytes taken from the recipient after transplantation. The comparison of assay results in the presence of, and in the absence of (or in the presence of reduced levels of) a cytokine growth factor such as interleukin-2, is used to determine whether the organ is being rejected. Also disclosed are kits for practicing these methods.
摘要翻译: 本文公开了用于监测移植受体的免疫状态的方法。 来自移植器官的成纤维细胞用于移植后从接受者获得的淋巴细胞的增殖试验。 使用细胞因子生长因子如白细胞介素-2的存在和不存在(或存在降低的水平)的测定结果的比较来确定器官是否被拒绝。 还公开了用于实施这些方法的试剂盒。
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