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公开(公告)号：US20090203027A1
公开(公告)日：2009-08-13
申请号：US12413102
申请日：2009-03-27
申请人： Jon Elliot Adler , Alexey Pronin , Huixian Tang , Mark Zoller
发明人： Jon Elliot Adler , Alexey Pronin , Huixian Tang , Mark Zoller
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/569
CPC分类号： C07K14/705 , A61K38/00
摘要： Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods employing the same, and methods for altering taste perception via administration of a T2R76 modulator. These T22R76 polypeptides can be expressed alone or co-expressed with another T2R polypeptide, preferably a different human T2R polypeptide.
摘要翻译： 编码T2R76多肽的分离的核酸，重组表达的T2R76多肽，用于重组表达T2R76多肽的异源表达系统，使用该多肽的测定方法以及通过施用T2R76调节剂改变味觉的方法。 这些T22R76多肽可以单独表达或与另一个T2R多肽，优选不同的人T2R多肽共表达。
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2.发明授权Use of specific T2R taste receptors to identify compounds that block bitter taste 有权使用特定的T2R味觉受体来鉴别抑制苦味的化合物公开(公告)号：US08071320B2
公开(公告)日：2011-12-06
申请号：US12854570
申请日：2010-08-11
申请人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
发明人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
IPC分类号： G01N33/566 , C07K14/705
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.
摘要翻译： 提供了用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的分析。 根据这些测定法鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹参）相关的苦味。 这些化合物是具有苦味的食品，饮料或药物制剂的有用添加剂。
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3.发明授权Use of specific T2R receptors to identify compounds that block bitter taste 有权使用特定的T2R受体来鉴定阻止苦味的化合物公开(公告)号：US07776561B2
公开(公告)日：2010-08-17
申请号：US12041956
申请日：2008-03-04
申请人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
发明人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparationshaving a bitter taste.
摘要翻译： 提供了用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的分析。 根据这些测定法鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹参）相关的苦味。 这些化合物是具有苦味的食品，饮料或药用制剂的有用添加剂。
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公开(公告)号：US07517972B2
公开(公告)日：2009-04-14
申请号：US10628464
申请日：2003-07-29
申请人： Jon Elliot Adler , Huixian Tang , Alexey Pronin
发明人： Jon Elliot Adler , Huixian Tang , Alexey Pronin
CPC分类号： C07K14/705 , A61K38/00
摘要： Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods employing the same, and methods for altering taste perception via administration of a T2R76 modulator. These T22R76 polypeptides can be expressed alone or co-expressed with another T2R polypeptide, preferably a different human T2R polypeptide.
摘要翻译： 编码T2R76多肽的分离的核酸，重组表达的T2R76多肽，用于重组表达T2R76多肽的异源表达系统，使用该多肽的测定方法以及通过施用T2R76调节剂改变味觉的方法。 这些T22R76多肽可以单独表达或与另一个T2R多肽，优选不同的人T2R多肽共表达。
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5.发明授权Use of specific T2R taste receptors to identify compounds that block bitter taste 有权使用特定的T2R味觉受体来鉴别抑制苦味的化合物公开(公告)号：US07338771B2
公开(公告)日：2008-03-04
申请号：US10191058
申请日：2002-07-10
申请人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
发明人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.
摘要翻译： 提供了用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的分析。 根据这些测定法鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹参）相关的苦味。 这些化合物是具有苦味的食品，饮料或药物制剂的有用添加剂。
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6.发明申请USE OF SPECIFIC T2R TASTE RECEPTORS TO IDENTIFY COMPOUNDS THAT BLOCK BITTER TASTE 有权特异性T2R受体受体的鉴别鉴定化合物公开(公告)号：US20100317035A1
公开(公告)日：2010-12-16
申请号：US12854570
申请日：2010-08-11
申请人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
发明人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.
摘要翻译： 提供了用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的分析。 根据这些测定法鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹参）相关的苦味。 这些化合物是具有苦味的食品，饮料或药物制剂的有用添加剂。
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公开(公告)号：US08338115B2
公开(公告)日：2012-12-25
申请号：US12413102
申请日：2009-03-27
申请人： Jon Elliot Adler , Alexey Pronin , Huixian Tang
发明人： Jon Elliot Adler , Alexey Pronin , Huixian Tang
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00
摘要： Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods employing the same, and methods for altering taste perception via administration of a T2R76 modulator. These T22R76 polypeptides can be expressed alone or co-expressed with another T2R polypeptide, preferably a different human T2R polypeptide.
摘要翻译： 编码T2R76多肽的分离的核酸，重组表达的T2R76多肽，用于重组表达T2R76多肽的异源表达系统，使用该多肽的测定方法以及通过施用T2R76调节剂改变味觉的方法。 这些T22R76多肽可以单独表达或与另一个T2R多肽，优选不同的人T2R多肽共表达。
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8.发明申请公开(公告)号：US20080268471A1
公开(公告)日：2008-10-30
申请号：US12041956
申请日：2008-03-04
申请人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
发明人： Alexey Pronin , Judy Connor , Huixian Tang , Walter Keung , Guy Servant , Jon Elliot Adler , Shawn O'Connell , Paul Brust
IPC分类号： G01N33/53 , G01N33/566
CPC分类号： G01N33/566 , G01N2333/726 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparationshaving a bitter taste.
摘要翻译： 提供了用于鉴定调节，优选抑制与激活hT2R4，hT2R44和/或hT2R61相关的苦味的化合物的分析。 根据这些测定法鉴定的化合物应调节，例如抑制与苦味化合物（包括奎宁，6-亚硝基糖精，糖精和/或丹参）相关的苦味。 这些化合物是具有苦味的食品，饮料或药用制剂的有用添加剂。
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9.发明授权Expression of functional human olfactory cyclic nucleotide gated (CNG) channel in recombinant host cells and use thereof in cell based assays to identify GPCR modulators 有权功能性人嗅环核苷酸门控（CNG）通道在重组宿主细胞中的表达及其在基于细胞的测定中的应用以鉴定GPCR调节剂公开(公告)号：US07052857B2
公开(公告)日：2006-05-30
申请号：US10189507
申请日：2002-07-08
申请人： Mark Zoller , Hong Xu , Lena Staszewski , Bryan Moyer , Alexey Pronin , Jon Elliot Adler , Guy Servant , Nicholas Callamaras
发明人： Mark Zoller , Hong Xu , Lena Staszewski , Bryan Moyer , Alexey Pronin , Jon Elliot Adler , Guy Servant , Nicholas Callamaras
IPC分类号： G01N33/567
CPC分类号： C07K14/705
摘要： The present invention relates to isolated nucleic acid sequences that encode human olfactory cyclic nucleotide gated (CNG) channel subunits, and the corresponding polypeptides. The invention further relates to the use of human CNG channels to profile, screen for, and identify compounds that modulate the human olfactory CNG channel. More specifically, the invention relates to the expression of the human olfactory CNG channel in cells, preferably mammalian cells, and the use of these cells in high throughput cell-based assays to identify compounds that enhance or block human olfactory CNG function. Compounds that activate the olfactory CNG channel will enhance smell and can be used to make foods more palatable for individuals with attenuated olfactory function. Conversely, compounds that inhibit the olfactory CNG channel will inhibit smell and can be use to block malodors. Additionally, the invention relates to the use of cell-based olfactory CNG channel assays to identify modulates of G-protein coupled receptor (GPCRs) and other proteins that regulate cyclic nucleotide levels.
摘要翻译： 本发明涉及编码人嗅环核苷酸门控（CNG）通道亚基的分离的核酸序列，以及相应的多肽。 本发明还涉及使用人类CNG通道来分析，筛选和鉴定调节人嗅觉CNG通道的化合物。 更具体地，本发明涉及人嗅觉CNG通道在细胞，优选哺乳动物细胞中的表达，以及这些细胞在高通量细胞分析中的应用，以鉴定增强或阻断人嗅觉CNG功能的化合物。 激活嗅觉CNG通道的化合物将增强气味，可用于使食物对于具有减弱的嗅觉功能的个体更可口。 相反，抑制嗅觉CNG通道的化合物将抑制气味，并可用于阻止恶臭。 另外，本发明涉及使用基于细胞的嗅觉CNG通道测定来鉴定调节环核苷酸水平的G蛋白偶联受体（GPCR）和其他蛋白质的调节。
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公开(公告)号：US08357499B2
公开(公告)日：2013-01-22
申请号：US11326441
申请日：2006-01-06
申请人： Mark Zoller , Hong Xu , Lena Staszewski , Bryan Moyer , Alexey Pronin , Jon Elliot Adler , Guy Servant , Nicholas Callamaras
发明人： Mark Zoller , Hong Xu , Lena Staszewski , Bryan Moyer , Alexey Pronin , Jon Elliot Adler , Guy Servant , Nicholas Callamaras
IPC分类号： G01N33/567 , C07K14/705 , C12N15/12
CPC分类号： C07K14/705
摘要： The present invention relates to isolated nucleic acid sequences that encode human olfactory cyclic nucleotide gated (CNG) channel subunits, and the corresponding polypeptides. The invention further relates to the use of human CNG channels to profile, screen for, and identify compounds that modulate the human olfactory CNG channel. More specifically, the invention relates to the expression of the human olfactory CNG channel in cells, preferably mammalian cells, and the use of these cells in high throughput cell-based assays to identify compounds that enhance or block human olfactory CNG function. Compounds that activate the olfactory CNG channel will enhance smell and can be used to make foods more palatable for individuals with attenuated olfactory function. Conversely, compounds that inhibit the olfactory CNG channel will inhibit smell and can be use to block malodors. Additionally, the invention relates to the use of cell-based olfactory CNG channel assays to identify modulates of G-protein coupled receptor (GPCRs) and other proteins that regulate cyclic nucleotide levels.
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