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    Structure-based identification of candidate compounds using three dimensional structures and models of Fc receptors
    2.
    发明授权
    Structure-based identification of candidate compounds using three dimensional structures and models of Fc receptors 失效
    使用三维结构和Fc受体模型的候选化合物的基于结构的鉴定

    公开(公告)号：US06675105B2

    公开(公告)日：2004-01-06

    申请号：US09245764

    申请日：1999-02-05

    申请人： P. Mark Hogarth ,  Maree S. Powell ,  Ian F. C. McKenzie ,  Kelly F. Maxwell ,  Thomas P. J. Garrett ,  Vidana Epa

    发明人： P. Mark Hogarth ,  Maree S. Powell ,  Ian F. C. McKenzie ,  Kelly F. Maxwell ,  Thomas P. J. Garrett ,  Vidana Epa

    IPC分类号： G06F1900

    CPC分类号： C07K14/70535 ,  A61K38/00 ,  C07K2299/00 ,  C12N2799/026 ,  Y02A90/26

    摘要： Disclosed are crystals, crystal structure Fc&ggr;RIIa protein, three dimensional coordinates of Fc&ggr;RIIa protein, and structures and models derived from the Fc&ggr;RIIa structure. Also disclosed are crystals of Fc&egr;RI protein and three dimensional coordinates of Fc&egr;RI protein monomers and dimers derived from the Fc&ggr;RIIa structure. Also disclosed are three dimensional coordinates of Fc&ggr;RIIIb proteins and models of Fc&ggr;RIIIb derived from the Fc&ggr;RIIa structure. The present invention also includes methods to produce such crystals, crystal structures and models. Uses of such crystals, crystal structures and models are also disclosed, including structure based drug design and therapeutic compositions.

    摘要翻译： 公开了晶体，晶体结构FcgammaRIIa蛋白，FcgammaRIIa蛋白的三维坐标，以及衍生自FcgammaRIIa结构的结构和模型。 还公开了FcepsilonRI蛋白的晶体和由FcγRIIa结构衍生的FcepsilonRI蛋白单体和二聚体的三维坐标。 还公开了FcgammaRIIIb蛋白质的三维坐标和来自FcγRIIa结构的FcγRIIIb的模型。 本发明还包括产生这种晶体，晶体结构和模型的方法。 还公开了这种晶体，晶体结构和模型的使用，包括基于结构的药物设计和治疗组合物。