公开(公告)号：US20080138383A1

公开(公告)日：2008-06-12

申请号：US11950989

申请日：2007-12-05

申请人： Jonathan David Bortz ,  R. Saul Levinson ,  Jeremy Donald Wang ,  Jisheng Ge

发明人： Jonathan David Bortz ,  R. Saul Levinson ,  Jeremy Donald Wang ,  Jisheng Ge

IPC分类号： A61K31/5513 ,  A61K31/4164 ,  A61K9/00 ,  A61P25/08 ,  A61K31/505

CPC分类号： A61K31/4164 ,  A61K9/0043 ,  A61K9/006 ,  A61K9/06 ,  A61K31/505 ,  A61K31/5513 ,  A61K47/10 ,  A61K47/36 ,  A61K47/38

摘要： This invention relates generally to pharmaceutical compositions for treating seizures, and, more particularly, to pharmaceutical compositions that are bioadherent to oral and/or nasal mucosa, comprise one or more anti-acute seizure agents, and can be used to treat one or more conditions selected from the group consisting of acute seizure, repetitive seizures, and status epilepticus. This invention also relates generally to methods for preparing such compositions, methods of treatment using such compositions, uses of such compositions to prepare medicaments, and kits comprising such compositions.

摘要翻译： 本发明一般涉及用于治疗癫痫发作的药物组合物，更具体地说，涉及对口腔和/或鼻粘膜具有生物粘附性的药物组合物，包含一种或多种抗急性发作剂，并且可用于治疗一种或多种病症 选自急性发作，重复性癫痫发作和癫痫持续状态组。 本发明一般还涉及制备这种组合物的方法，使用这种组合物的治疗方法，这种组合物的用途来制备药物，以及包含这些组合物的试剂盒。

公开(公告)号：US20080299050A1

公开(公告)日：2008-12-04

申请号：US11865476

申请日：2007-10-01

申请人： Jonathan David Bortz ,  R. Saul Levinson ,  Jisheng Ge ,  Jeremy Donald Wang

发明人： Jonathan David Bortz ,  R. Saul Levinson ,  Jisheng Ge ,  Jeremy Donald Wang

IPC分类号： A61K8/18 ,  A61K31/4166 ,  A61K31/485 ,  A61P25/04

CPC分类号： A61K31/415 ,  A61K31/485

摘要： A method for treating oral mucositis in a subject comprises topically administering to an oral mucosal surface of the subject phenyloin or a pharmaceutically acceptable salt thereof in an amount effective to inhibit mucosal degeneration or promote mucosal regeneration, and optionally an analgesic agent in an amount effective, in combination with the phenyloin or salt thereof, to reduce pain associated with the oral mucositis. The phenyloin or salt thereof and optionally the analgesic agent can be administered in a pharmaceutical composition comprising an excipient vehicle suitable for intraoral administration, said composition being bioadhesive to an oral mucosal surface, for example having at least one non-lipoidal internal phase and at least one lipoidal external phase that is bioadhesive to said surface.

摘要翻译： 用于治疗受试者口腔粘膜炎的方法包括以有效抑制粘膜变性或促进粘膜再生的量局部给予受试者苯ylo嗪的口腔粘膜表面或其药学上可接受的盐，以及任选的止痛剂， 与苯丙氨酸或其盐组合，以减少与口腔粘膜炎相关的疼痛。 苯丙氨酸或其盐和任选的止痛剂可以在包含适合于口内给药的赋形剂载体的药物组合物中施用，所述组合物对口腔粘膜表面具有生物粘附性，例如具有至少一个非脂质内相，并且至少 一个与所述表面生物粘附的脂质外部相。

公开(公告)号：US06407042B1

公开(公告)日：2002-06-18

申请号：US09534560

申请日：2000-03-24

申请人： Anthony J. I. Ward ,  Jisheng Ge ,  Jane L. Gillespie ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

发明人： Anthony J. I. Ward ,  Jisheng Ge ,  Jane L. Gillespie ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

IPC分类号： A01N2500

CPC分类号： A01N47/24 ,  A01N25/28 ,  A01N25/30 ,  A01N33/22 ,  A01N35/06 ,  A01N37/22 ,  A01N37/40 ,  A01N39/04 ,  A01N41/04 ,  A01N43/40 ,  A01N43/50 ,  A01N47/36 ,  A01N57/20 ,  Y10S514/975 ,  A01N25/08 ,  A01N25/04 ,  A01N37/48 ,  A01N37/26 ,  A01N25/02 ,  A01N2300/00

摘要： A composition is disclosed for application to a plant that comprises an exogenous chemical (for example, a postemergent herbicide), an aqueous diluent, and a first excipient substance that is amphiphilic. The weight/weight ratio of the first excipient substance to the exogenous chemical is between about 1:3 and about 1:100. The aqueous composition forms anisotropic aggregates on a wax layer, and the presence of the anisotropic aggregates can be detected by a test described herein. Compositions of the present invention, when applied to plants, provide enhanced biological activity per unit amount of exogenous chemical, as compared to otherwise similar compositions containing surfactants that do not form anisotropic aggregates. Without being bound by theory, it is presently believed that this enhanced biological activity results from the formation or enlargement of hydrophilic channels through the epicuticular wax of the plant.

摘要翻译： 公开了一种用于植物的组合物，其包含外源化学物质（例如，出芽后除草剂），水性稀释剂和两亲性的第一赋形物质。 第一赋形物质与外源性化学物质的重量/重量比为约1:3至约1:100。 水性组合物在蜡层上形成各向异性聚集体，并且各向异性聚集体的存在可以通过本文所述的测试来检测。 与其它相似的含有不形成各向异性聚集体的表面活性剂的组合物相比，本发明的组合物当应用于植物时，提供每单位量外源化学品的增强的生物活性。 不受理论的约束，目前认为这种增强的生物活性是由于通过植物的表皮蜡形成或扩大亲水性通道而产生的。

公开(公告)号：US6093681A

公开(公告)日：2000-07-25

申请号：US958149

申请日：1997-10-24

申请人： Anthony J. I. Ward ,  Jisheng Ge ,  Jane L. Gillespie ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

发明人： Anthony J. I. Ward ,  Jisheng Ge ,  Jane L. Gillespie ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

IPC分类号： A01N25/08 ,  A01N25/04 ,  A01N25/28 ,  A01N25/30 ,  A01N33/22 ,  A01N35/06 ,  A01N37/22 ,  A01N37/40 ,  A01N39/04 ,  A01N41/04 ,  A01N43/40 ,  A01N43/50 ,  A01N47/24 ,  A01N47/36 ,  A01N57/12 ,  A01N57/20 ,  G01N21/84 ,  G01N33/15 ,  G01N33/48

CPC分类号： A01N47/24 ,  A01N25/28 ,  A01N25/30 ,  A01N33/22 ,  A01N35/06 ,  A01N37/22 ,  A01N37/40 ,  A01N39/04 ,  A01N41/04 ,  A01N43/40 ,  A01N43/50 ,  A01N47/36 ,  A01N57/20 ,  Y10S514/975

摘要： A composition is disclosed for application to a plant that comprises an exogenous chemical (for example, a postemergent herbicide), an aqueous diluent, and a first excipient substance that is amphiphilic. The weight/weight ratio of the first excipient substance to the exogenous chemical is between about 1:3 and about 1:100. The aqueous composition forms anisotropic aggregates on a wax layer, and the presence of the anisotropic aggregates can be detected by a test described herein. Compositions of the present invention, when applied to plants, provide enhanced biological activity per unit amount of exogenous chemical, as compared to otherwise similar compositions containing surfactants that do not form anisotropic aggregates. Without being bound by theory, it is presently believed that this enhanced biological activity results from the formation or enlargement of hydrophilic channels through the epicuticular wax of the plant.

摘要翻译： 公开了一种用于植物的组合物，其包含外源化学物质（例如，出芽后除草剂），水性稀释剂和两亲性的第一赋形物质。 第一赋形物质与外源性化学物质的重量/重量比为约1:3至约1:100。 水性组合物在蜡层上形成各向异性聚集体，并且各向异性聚集体的存在可以通过本文所述的测试来检测。 与其它相似的含有不形成各向异性聚集体的表面活性剂的组合物相比，本发明的组合物当应用于植物时，提供每单位量外源化学品的增强的生物活性。 不受理论的束缚，目前认为这种增强的生物活性是由于通过植物的表皮蜡形成或增加亲水性通道而产生的。

公开(公告)号：US6130186A

公开(公告)日：2000-10-10

申请号：US957631

申请日：1997-10-24

申请人： Anthony J. I. Ward ,  Jisheng Ge ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

发明人： Anthony J. I. Ward ,  Jisheng Ge ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

IPC分类号： A01N25/04 ,  A01N25/28 ,  A01N25/30 ,  A01N37/22 ,  A01N37/40 ,  A01N43/40 ,  A01N43/50 ,  A01N47/24 ,  A01N47/36 ,  A01N57/20

CPC分类号： A01N47/24 ,  A01N25/28 ,  A01N25/30 ,  A01N37/22 ,  A01N37/40 ,  A01N43/40 ,  A01N43/50 ,  A01N47/36 ,  A01N57/20

摘要： Methods and compositions are disclosed wherein exogenous chemicals are applied to plants to generate a desired biological response. One embodiment of the present invention is a plant treatment composition that comprises an exogenous chemical and a first excipient substance. The first excipient substance is an amphiphilic quaternary ammonium compound or mixture of such compounds, having the formulaR.sup.8 --W.sub.a --X--Y.sub.b --(CH.sub.2).sub.n --N.sup.+ (R.sup.9)(R.sup.10)(R.sup.11) T.sup.-wherein R.sup.8 represents the hydrophobic moiety and is a hydrocarbyl or haloalkyl group having from about 6 to about 22 carbon atoms, W and Y are independently O or NH, a and b are independently 0 or 1 but at least one of a and b is 1, X is CO, SO or SO.sub.2, n is 2 to 4, R.sup.9, R.sup.10 and R.sup.11 are independently C.sub.1-4 alkyl, and T is a suitable anion.

摘要翻译： 公开了将外源性化学品施用于植物以产生期望的生物反应的方法和组合物。 本发明的一个实施方案是包含外源化学品和第一赋形剂物质的植物处理组合物。 第一赋形剂物质是具有式R8-Wa-X-Yb-（CH2）n-N +（R9）（R10）（R11）T-的两亲性季铵化合物或这些化合物的混合物，其中R8代表疏水部分 并且是具有约6至约22个碳原子的烃基或卤代烷基，W和Y独立地为O或NH，a和b独立地为0或1，但a和b中的至少一个为1，X为CO，SO 或SO 2，n为2至4，R 9，R 10和R 11独立地为C 1-4烷基，T为合适的阴离子。

公开(公告)号：US06475953B1

公开(公告)日：2002-11-05

申请号：US09534772

申请日：2000-03-24

申请人： Anthony J. I. Ward ,  Jisheng Ge ,  Jane L. Gillespie ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

发明人： Anthony J. I. Ward ,  Jisheng Ge ,  Jane L. Gillespie ,  Joseph J. Sandbrink ,  Xiaodong C. Xu

IPC分类号： A01N2530

CPC分类号： A01N47/24 ,  A01N25/28 ,  A01N25/30 ,  A01N33/22 ,  A01N35/06 ,  A01N37/22 ,  A01N37/40 ,  A01N39/04 ,  A01N41/04 ,  A01N43/40 ,  A01N43/50 ,  A01N47/36 ,  A01N57/20 ,  Y10S514/975 ,  A01N25/08 ,  A01N25/04 ,  A01N37/48 ,  A01N37/26 ,  A01N25/02 ,  A01N2300/00

摘要： A composition is disclosed for application to a plant that comprises glyphosate, an aqueous diluent, and an excipient substance that is amphiphilic. The weight/weight ratio of the excipient substance to the exogenous chemical is between about 1:3 and about 1:100. The aqueous composition forms anisotropic aggregates on a wax layer, and the presence of the anisotropic aggregates can be detected by a test described herein. Compositions of the present invention, when applied to plants, provide enhanced biological activity per unit amount of glyphosate, as compared to otherwise similar compositions containing surfactants that do not form anisotropic aggregates. Without being bound by theory, it is presently believed that this enhanced biological activity results from the formation or enlargement of hydrophilic channels through the epicuticular wax of the plant.

摘要翻译： 公开了用于施用于包含草甘膦，水性稀释剂和两亲性赋形物质的植物的组合物。 赋形剂物质与外源性化学物质的重量/重量比为约1:3至约1:100。 水性组合物在蜡层上形成各向异性聚集体，并且各向异性聚集体的存在可以通过本文所述的测试来检测。 与应用于植物的组合物相比，含有不形成各向异性聚集体的表面活性剂的相似组合物相比，每单位量草甘膦提供增强的生物活性。 不受理论的约束，目前认为这种增强的生物活性是由于通过植物的表皮蜡形成或扩大亲水性通道而产生的。