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公开(公告)号：US6097188A
公开(公告)日：2000-08-01
申请号：US381230
申请日：1995-01-31
CPC分类号： G01R33/5604
摘要： The present invention provides an NMR apparatus comprising an analyte sample holder having a containment region that holds a volume of less than about 10 microliters of the analyte sample, a microcoil, which encloses the containment region of the analyte sample holder and the analyte sample contained therein, the microcoil having an inside dimension of less than about 1 mm, and the microcoil operatively associated with the analyte sample contained in the containment region of the analyte sample holder such that the microcoil can transmit and/or receive energy from the analyte sample in the containment region of the analyte sample holder, and a magnet having a mass less than about 50 kg, the magnet positioned about the microcoil and the analyte sample in the containment region of the analyte sample holder to provide a static magnetic field in which the microcoil and the analyte sample in the containment region of the analyte sample holder are located, wherein the microcoil and the magnet provide for the obtainment of an NMR spectrum. The present invention also provides a method of analysis and elucidation of the chemical structure of an analyte using NMR, the method comprising providing an analyte sample that has a volume of less than about 10 microliters, enclosing the analyte sample in a microcoil, generating a static magnetic field about the analyte sample using a magnet, transmitting energy to the analyte sample to excite the sample from its equilibrium state to its excited state, detecting the energy emitted from the analyte sample when the sample relaxes from its excited state to its equilibrium state using the microcoil, and analyzing and graphically displaying the detected energy as a time or frequency domain spectrum.
摘要翻译： 本发明提供一种NMR装置，其包括分析物样品保持器，其具有容纳小于约10微升分析物样品的容纳区域，包围分析物样品架的容纳区域和其中包含的分析物样品的微线圈 ，所述微线圈具有小于约1mm的内部尺寸，并且所述微线圈与分析物样品保持器的容纳区域中包含的分析物样品可操作地相关联，使得所述微线圈可以从所述分析物样品中传输和/或接收能量 分析物样品保持器的容纳区域和质量小于约50kg的磁体，磁体围绕微线圈和分析物样品位于分析物样品保持器的容纳区域中，以提供静态磁场，其中微线圈和 位于分析物样品架的容纳区域中的分析物样品，其中微线圈和磁体 提供获得NMR光谱。 本发明还提供了使用NMR分析和分析分析物的化学结构的方法，所述方法包括提供具有小于约10微升的体积的分析物样品，将分析物样品包封在微线圈中，产生静电 使用磁体关于分析物样品的磁场，将能量传递到分析物样品以将样品从其平衡态激发到其激发态，当样品从其激发态松弛至其平衡状态时，检测从分析物样品发射的能量，使用 微线圈，并分析和图形显示检测到的能量作为时域或频域光谱。
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公开(公告)号：US06788061B1
公开(公告)日：2004-09-07
申请号：US10252655
申请日：2002-09-23
IPC分类号： G01V300
CPC分类号： G01R33/302 , G01R33/46
摘要： The present invention provides and NMR apparatus comprising an analyte sample holder having a containment region that holds a volume of less than about 1 microliters of the analyte sample, a coil, which encloses the containment region of the analyte sample holder and the analyte sample contained therein, the coil operatively associated with the analyte sample contained in the containment region of the analyte sample holder such that the coil can transmit and/or receive energy from the analyte sample in the containment region of the analyte sample holder, and a magnet to provide a static magnetic field in which the coil and the analyte sample in the containment region of the analyte sample holder are located, wherein the coil and the magnet provide for the obtainment of an NMR spectrum having a spectral line width resolution of less than about 0.1 parts per million.
摘要翻译： 本发明提供了包括具有容纳区域的分析物样品保持器的NMR装置，所述容纳区域保持小于约1微升的分析物样品的体积，包围分析物样品保持器的容纳区域和其中包含的分析物样品的线圈 ，所述线圈与分析物样品保持器的容纳区域中包含的分析物样品可操作地相关联，使得线圈可以从分析物样品保持器的容纳区域中的分析物样品和磁体传输和/或接收能量，以提供 其中线圈和分析物样品架的容纳区域中的分析物样品位于其中的静磁场，其中线圈和磁体提供获得具有小于约0.1份的谱线宽度分辨率的NMR光谱 百万。
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3.发明授权
公开(公告)号：US5684401A
公开(公告)日：1997-11-04
申请号：US595269
申请日：1996-02-01
CPC分类号： G01R33/56536 , G01R33/5604 , G01R33/302 , G01R33/34053 , G01R33/341
摘要： An apparatus and method for compensation of magnetic susceptibility variation in NMR microspectroscopy detection microcoils. NMR detection microcoils are formed with side-by-side windings in order to approximate a uniform cylindrical sheet coil. The wire may have a thin layer of insulation in order to prevent shorting between adjacent turns, or (if the wire diameter is small enough) uninsulated wire may be wound with the adjacent turns touching without fear of shorting between coil turns. Additionally, a susceptibility matching medium, such as a perfluorinated hydrocarbon, may be placed around the microcoil to minimize susceptibility-induced variations in the B.sub.0 magnetic field.
摘要翻译： NMR显微光谱检测微线圈磁化率变化的装置和方法。 NMR检测微线圈由并排绕组形成，以便近似均匀的圆柱形片状线圈。 导线可以具有薄的绝缘层，以防止相邻匝之间的短路，或者（如果导线直径足够小），非绝缘线可以在相邻匝之间缠绕而不用担心线圈匝之间的短路。 此外，易位性匹配介质，例如全氟化烃，可放置在微线圈周围，以最小化磁化率诱导的B0磁场变化。
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4.发明授权
公开(公告)号：US5654636A
公开(公告)日：1997-08-05
申请号：US706924
申请日：1996-09-03
IPC分类号： G01R33/46
CPC分类号： G01R33/46
摘要： A method and apparatus for structural elucidation and determination of a nanoliter size sample of analyte. The method includes separating the analyte using a microseparation technique and then substantially simultaneously analyzing or detecting the sample using a nuclear magnetic resonance (NMR) spectrometer. The apparatus includes an RF microcoil positioned for operable communication with a capillary member of the microseparation system and the NMR spectrometer to provide enhanced sensitivity and improved signal-to-noise ratio of the NMR spectrometer necessary to accurately analyze or detect nanoliter size samples.
摘要翻译： 用于结构阐明和测定分析物的纳升尺寸样品的方法和装置。 该方法包括使用微分离技术分离分析物，然后使用核磁共振（NMR）光谱仪基本上同时分析或检测样品。 该装置包括被定位用于与微分离系统的毛细管构件和NMR光谱仪可操作连通的RF微线圈，以提供精确分析或检测纳升尺寸样品所需的NMR光谱仪的增强的灵敏度和改善的信噪比。
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公开(公告)号：US4859972A
公开(公告)日：1989-08-22
申请号：US265499
申请日：1988-11-01
IPC分类号： H01P1/185
CPC分类号： H01P1/185
摘要： A continuous microstrip phase shifter suitable for use in a phased array microwave hyperthermia system operating at 915 MHz is provided. The phase shifter utilizes a three dB quadrature hybrid coupler in conjunction with microstrip lines to change the phase of a transmitted wave. The phase change is introduced through the reflection ports of the coupler which are loaded with identical parallel resonant circuits. An abrupt junction varactor capacitance in parallel with a distributed inductance forms a voltage-tunable resonant circuit. The resonant element values are chosen to give a specified continuous phase variation with minimum transmission loss. This is accomplished without additional microwave circuit elements.
摘要翻译： 提供适用于以915MHz工作的相控阵微波热疗系统的连续微带移相器。 移相器利用三分频正交混合耦合器结合微带线来改变发射波的相位。 相位变化通过耦合器的反射端口引入，该反射端口装载有相同的并联谐振电路。 与分布电感并联的突变结变容二极管电容形成电压可调谐谐振电路。 选择谐振元件值以给出具有最小传输损耗的规定的连续相位变化。 这是在没有附加的微波电路元件的情况下实现的。
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