-
公开(公告)号：US20100143455A1
公开(公告)日：2010-06-10
申请号：US12584486
申请日：2009-09-05
申请人： Nian Wu , Brian Charles Keller
发明人： Nian Wu , Brian Charles Keller
IPC分类号： A01N25/00 , C07D295/027 , A01N43/60 , A01P3/00
CPC分类号： A01N43/653 , A61K31/675 , C07D307/04 , C07D407/04 , C07D407/06 , C07D407/14
摘要： New triazole antifungal agents having C6S7 or S6C7 bridges are disclosed. These triazoles provide alternatives to existing antifungals in terms of formulation, bioavailability and activity.
摘要翻译： 公开了具有C6S7或S6C7桥的新三唑抗真菌剂。 这些三唑在制剂，生物利用度和活性方面提供了现有抗真菌剂的替代品。
-
公开(公告)号：US07567715B1
公开(公告)日：2009-07-28
申请号：US11128408
申请日：2005-05-12
申请人： Song-Chun Zhu , Cheng-en Guo , Ying-Nian Wu
发明人： Song-Chun Zhu , Cheng-en Guo , Ying-Nian Wu
CPC分类号： G06K9/4638 , G06K9/469
摘要： A system and method for representing and encoding an input image. Pixels associated with the structural part of the image are referred to as “sketchable,” and pixels associated with the texture part are referred to as “non-sketchable.” A sketch graph, Ssk, is generated for the sketchable part of the input image by iteratively selecting a plurality of optimal image primitives from a dictionary of image primitives. The sketch graph may then be refined to achieve good Gestalt organization and resolve ambiguities in the graph. The non-sketchable texture regions of the image, Snsk, are computed via a simple texture clustering algorithm. In reconstructing the sketchable part of the input image, the image primitives are aligned on the sketch graph. In reconstructing the non-sketchable part of the input image, the MRF models are simulated to reproduce statistical summaries of the various texture regions using the sketchable part as boundary condition.
摘要翻译： 一种用于表示和编码输入图像的系统和方法。 与图像的结构部分相关联的像素被称为“可绘制”，并且与纹理部分相关联的像素被称为“不可绘制”。 通过从图像原语的字典中迭代地选择多个最佳图像原语，为输入图像的可缩放部分生成草图Ssk。 然后可以对草图进行细化，以实现良好的格式塔组织，并解决图中的歧义。 通过简单的纹理聚类算法计算图像Snsk的不可裁剪纹理区域。 在重建输入图像的可略图部分时，图像原语在草图上对齐。 在重建输入图像的不可略换部分时，模拟MRF模型，以使用可选部分作为边界条件再现各种纹理区域的统计摘要。
-
公开(公告)号：US20160375150A1
公开(公告)日：2016-12-29
申请号：US15184015
申请日：2016-06-16
申请人： Nian Wu
发明人： Nian Wu
IPC分类号： A61K47/48
CPC分类号： A61K47/6851 , A61K9/08 , A61K31/05 , A61K31/337 , A61K31/496 , A61K31/506 , A61K31/57 , A61K31/7068 , A61K47/48969 , A61K47/542 , A61K47/554 , A61K47/60 , A61K47/6951 , C07J9/00 , C07J41/0055 , C08B37/0012 , C08B37/0015
摘要： The invention comprises compounds, methods of making, and methods of using. A group of polymer-cyclodextrin-lipid conjugates having a center backbone and three or four appended functional groups are disclosed, wherein one of the hydrophilic components is cyclodextrin. The compounds may have a backbone with three or four appended functional groups: one or two lipophilic compounds including sterols or “fat soluble” vitamins or fatty acids, one or two hydrophilic polymer and one cyclodextrin. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. Typical coupling reaction of the conjugates may involve one or more or combinations or in series of alkylation including N-alkylation or O-alkylation, etherification, esterification and amidation chemical processes. A variety of linkers between the center backbone and functional groups may also be selected to modify the carriers or center backbones for the coupling reactions and optimize performance of the conjugates.
摘要翻译： 本发明包括化合物，制备方法和使用方法。 公开了一组具有中心主链和三个或四个附加官能团的聚合物 - 环糊精 - 脂质缀合物，其中亲水组分之一是环糊精。 化合物可以具有带有三个或四个附加官能团的骨架：一种或两种亲脂性化合物，包括甾醇或“脂溶性”维生素或脂肪酸，一种或两种亲水性聚合物和一种环糊精。 可以在配制药物，化妆品，营养品等中的特定应用中选择特定的官能团。 缀合物的典型偶联反应可以包括一种或多种或组合或串联烷基化，包括N-烷基化或O-烷基化，醚化，酯化和酰胺化学过程。 还可以选择中心骨架和官能团之间的各种连接体，以修饰偶联反应的载体或中心骨架，并优化缀合物的性能。
-
公开(公告)号：US20120232169A1
公开(公告)日：2012-09-13
申请号：US13412676
申请日：2012-03-06
申请人： Nian Wu , Brian Charles Keller
发明人： Nian Wu , Brian Charles Keller
CPC分类号： A61K47/14 , A61K9/0014 , A61K9/0019 , A61K9/0048 , A61K9/0095 , A61K9/4858 , A61K31/7052 , A61K38/13 , A61K47/28 , A61K47/60 , A61K47/6911
摘要： (PEG)-lipid conjugates and methods of preparation are disclosed herein. Methods of preparation may involve stepwise addition of small PEG oligomers to a glycerol backbone until a desired chain size is attained. Polymers resulting from the syntheses may be highly monodisperse. The resulting polymers may comprise branched polyethyleneglycol (PEG)-lipid conjugates. The present disclosure may provide several advantages such as simplified synthesis, high product yield and low cost for starting materials. The present synthesis method may be suitable for preparing a wide range of conjugates such as PEG lipid conjugates having a glycerol-like central backbone covalently attached to two or more monodisperse PEG chains and a lipid comprising a range of diesters made from fatty acids or bile acids.
摘要翻译： （PEG）脂质偶联物和制备方法在本文中公开。 制备方法可以包括将小PEG低聚物逐步添加到甘油骨架中，直至达到所需的链尺寸。 由合成得到的聚合物可能是高度单分散的。 所得聚合物可以包含支链聚乙二醇（PEG） - 脂质缀合物。 本公开可以提供几个优点，例如简化的合成，高产率和起始材料的低成本。 本发明的合成方法可适用于制备宽范围的缀合物，例如具有共价连接到两个或更多个单分散PEG链的甘油样中心骨架的PEG脂质缀合物和包含由脂肪酸或胆汁酸制成的一系列二酯的脂质 。
-
公开(公告)号：US20120202890A1
公开(公告)日：2012-08-09
申请号：US13354726
申请日：2012-01-20
申请人： Nian Wu
发明人： Nian Wu
CPC分类号： C07H1/00 , A61K9/0014 , A61K9/0019 , A61K9/0048 , A61K9/0095 , A61K9/2013 , A61K31/05 , A61K31/223 , A61K31/231 , A61K31/25 , A61K31/325 , A61K31/4188 , A61K31/575 , A61K31/7032 , A61K47/26 , C07H15/04 , C07J41/0061 , C08G65/329 , C08L2203/02
摘要： The invention comprises compounds, methods of making, and methods of using. The compounds may have a backbone and three appended functional groups: one lipid, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. A variety of linkers between the backbone and functional groups may also be selected to optimize performance.
-
公开(公告)号：US20110040113A1
公开(公告)日：2011-02-17
申请号：US12802197
申请日：2010-06-01
申请人： Nian Wu , Brian Charles Keller
发明人： Nian Wu , Brian Charles Keller
CPC分类号： C08G65/329 , A61K47/60 , A61K47/6911 , C08L2203/02
摘要： Syntheses of polyethyleneglycol (PEG)-lipid conjugates are disclosed. Such syntheses involve stepwise addition of small PEG oligomers to a glycerol backbone until the desired chain size is attained. Polymers resulting from the syntheses are highly monodisperse. The present invention provides several advantages such as simplified synthesis, high product yield and low cost for starting materials. The present synthesis method is suitable for preparing a wide range of conjugates.In another aspect, the invention comprises PEG lipid conjugates having a glycerol backbone covalently attached to one or two monodisperse PEG chains and one or two lipids. These conjugates are especially useful for pharmaceutical formulations.
摘要翻译： 公开了聚乙二醇（PEG）脂质缀合物的合成。 这种合成包括将小PEG低聚物逐步加入到甘油骨架中，直到达到所需的链尺寸。 由合成产生的聚合物是高度单分散的。 本发明提供了诸如简化合成，高产品收率和起始材料成本低等优点。 本合成方法适用于制备宽范围的共轭物。 在另一方面，本发明包括具有共价连接到一个或两个单分散PEG链和一个或两个脂质的甘油主链的PEG脂质缀合物。 这些缀合物对于药物制剂特别有用。
-
公开(公告)号：US20100240883A1
公开(公告)日：2010-09-23
申请号：US12661465
申请日：2010-03-17
申请人： Nian Wu , Brian Charles Keller
发明人： Nian Wu , Brian Charles Keller
IPC分类号： C07C233/38 , C07D207/46 , C07H5/06 , C07H19/06 , C07D411/04
CPC分类号： C07D411/04 , C07C237/04 , C07C237/22 , C07C257/20 , C07C2601/14 , C07C2603/74 , C07D207/46 , C07H5/06 , C07H13/04 , C07H13/06 , C07H15/24 , C07H19/073
摘要： New prodrugs are derived from highly water soluble parent drugs that exist as primary or secondary amines in their parent form. Lipophilic carrier groups are bonded to the parent drug via an amide linkage with additional linker elements between the amide group and the carrier group.
摘要翻译： 新的前药衍生自作为其母体形式的伯胺或仲胺的高度水溶性母体药物。 亲脂性载体基团通过与酰胺基团和载体基团之间的另外的接头元件的酰胺键与母体药物结合。
-
公开(公告)号：US20150064283A1
公开(公告)日：2015-03-05
申请号：US14535439
申请日：2014-11-07
申请人： Nian Wu
发明人： Nian Wu
IPC分类号： A61K47/26 , A61K31/506 , A61K31/337 , A61K31/496 , A61K31/05 , A61K33/24
CPC分类号： A61K47/26 , A61K9/0019 , A61K9/08 , A61K9/141 , A61K9/1617 , A61K9/1641 , A61K31/05 , A61K31/337 , A61K31/496 , A61K31/506 , A61K33/24 , A61K47/14 , A61K47/34
摘要： The invention comprises various aqueous PEG-carbohydrate-lipid based formulations of pharmaceutical active ingredients including compositions for intravenous injections. This invention relates to methods and compositions for improving solubility and the safety profile of pharmaceutical compounds. More particularly, the present invention relates to employing PEG-carbohydrate-lipid conjugates for formulating drug compositions having increased solubility or dispersivity and enhanced stability.
摘要翻译： 本发明包括各种药物活性成分的基于PEG-碳水化合物 - 脂质的水性基质制剂，包括用于静脉内注射的组合物。 本发明涉及用于提高药物化合物的溶解性和安全性的方法和组合物。 更具体地，本发明涉及使用PEG-碳水化合物 - 脂质缀合物来配制具有增加的溶解度或分散性和增强的稳定性的药物组合物。
-
公开(公告)号：US20150023892A1
公开(公告)日：2015-01-22
申请号：US14332692
申请日：2014-07-16
申请人： Nian Wu
发明人： Nian Wu
摘要： An antiseptic, polymer-lipid or emulsification agents-based aqueous composition can be used for intraoral removal of denture adhesive residuals. More particularly, the present invention relates to employing a polymer-lipid based or a mixture of polymer-lipids and emulsification agents or a mixture of emulsification agents and Co-emulsification agents for convenient and effective removing the denture adhesive residuals intra mouth or a combination of two ore more polymer-lipids or emulsification agents or Co-emulsification agents thereof.
摘要翻译： 基于防腐剂，聚合物 - 脂质或乳化剂的水性组合物可用于口腔内去除义齿粘合剂残留物。 更具体地说，本发明涉及使用聚合物 - 脂质或聚合物 - 脂质和乳化剂的混合物或乳化剂和共乳化剂的混合物，以方便和有效地去除口腔内的义齿粘合剂残留物或组合 两种以上的聚合物 - 脂质或乳化剂或其共乳化剂。
-
公开(公告)号：US20120202979A1
公开(公告)日：2012-08-09
申请号：US13364967
申请日：2012-02-02
申请人： Nian Wu
发明人： Nian Wu
CPC分类号： C07H1/00 , A61K9/0014 , A61K9/0019 , A61K9/0048 , A61K9/0095 , A61K9/2013 , A61K31/05 , A61K31/223 , A61K31/231 , A61K31/25 , A61K31/325 , A61K31/4188 , A61K31/575 , A61K31/7032 , A61K47/26 , C07H15/04 , C07J41/0061 , C08G65/329 , C08L2203/02
摘要： The invention comprises compounds, methods of making, and methods of using. The compounds may have a backbone and three appended functional groups: one lipid, one hydrophilic polymer, and one carbohydrate. Specific functional groups may be selected for specific applications in formulating pharmaceuticals, cosmetics, nutriceuticals, and the like. A variety of linkers between the backbone and functional groups may also be selected to optimize performance.
摘要翻译： 本发明包括化合物，制备方法和使用方法。 化合物可以具有主链和三个附加的官能团：一种脂质，一种亲水聚合物和一种碳水化合物。 可以在配制药物，化妆品，营养品等中的特定应用中选择特定的官能团。 骨架和功能组之间的各种接头也可以被选择以优化性能。
-
-
-
-
-
-
-
-
-
搜索结果
27 条记录 (耗时 0.025 秒)
