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1.发明授权Cyclic peptide from Nonomuraea sp., process for the production thereof, and pharmaceutical composition for the prevention or treatment of mycobacteria related disease comprising the same 有权来自Nonomuraea sp。的环肽，其制备方法，以及用于预防或治疗包含其的分枝杆菌相关疾病的药物组合物公开(公告)号：US09090667B2
公开(公告)日：2015-07-28
申请号：US14112720
申请日：2012-04-18
申请人： Jong Woo Kim , Sang Wook Lee , Sang Jin Park , Joo Won Suh , In Ae Lee , Tae Mi Yoon , Jong Keun Choi , Ji Ean Lee , Jin Yong Kim , Ying Yu Jin , Scott Franzblau , Sanghyun Cho , Wei Gao , Guido Pauli , James McAlpine , Jose Napolitano , Birgit Jaki , Brent Friesen , Maria Florencia Rodriguez Brasco , David Lankin
发明人： Jong Woo Kim , Sang Wook Lee , Sang Jin Park , Joo Won Suh , In Ae Lee , Tae Mi Yoon , Jong Keun Choi , Ji Ean Lee , Jin Yong Kim , Ying Yu Jin , Scott Franzblau , Sanghyun Cho , Wei Gao , Guido Pauli , James McAlpine , Jose Napolitano , Birgit Jaki , Brent Friesen , Maria Florencia Rodriguez Brasco , David Lankin
摘要： The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis, including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.
摘要翻译： 本发明涉及来自Nonomuraea sp。的新型抗TB环肽。 MJM5123是生产抗结核肽的方法和用于预防和治疗包含其的分枝杆菌感染的药物组合物。 本发明的组合物对复制/非复制性结核分枝杆菌（包括MDR和XDR菌株）具有高度活性，因此可有效地用作结核病的治疗剂。
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2.发明申请CYCLIC PEPTIDE FROM NONOMURAEA SP., PROCESS FOR THE PRODUCTION THEREOF, AND PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF MYCOBACTERIA RELATED DISEASE COMPRISING THE SAME 有权非生产菌株的循环肽，其生产方法和用于预防或治疗包含其的MYCOBACTERIA相关疾病的药物组合物公开(公告)号：US20140142031A1
公开(公告)日：2014-05-22
申请号：US14112720
申请日：2012-04-18
申请人： Jong Woo Kim , Sang Wook Lee , Sang jin Park , Joo Won Suh , In Ae Lee , Tae Mi Yoon , Jong Keun Choi , Ji Ean Lee , Jin Yong Kim , Ying Yu Jin , Scott Franzblau , Sanghyum Cho , Wei Gao , Guido Pauli , James McAlpine , Jose Napolitano , Birgit Jaki , Brent Friesen , Maria Florencia Rodriguez Brasco , David Lankin
发明人： Jong Woo Kim , Sang Wook Lee , Sang jin Park , Joo Won Suh , In Ae Lee , Tae Mi Yoon , Jong Keun Choi , Ji Ean Lee , Jin Yong Kim , Ying Yu Jin , Scott Franzblau , Sanghyum Cho , Wei Gao , Guido Pauli , James McAlpine , Jose Napolitano , Birgit Jaki , Brent Friesen , Maria Florencia Rodriguez Brasco , David Lankin
IPC分类号： C07K7/54
摘要： The present invention relates to novel anti-TB cyclic peptides from Nonomuraea sp. MJM5123, a process for the production of the anti-Tuberculosis peptide and a pharmaceutical composition for the prevention and treatment of mycobacterial infection comprising the same. The composition of the present invention is highly active against replicating/non-replicating M. tuberculosis, including MDR and XDR strains, so that it can be effectively used as a therapeutic agent for tuberculosis.
摘要翻译： 本发明涉及来自Nonomuraea sp。的新型抗TB环肽。 MJM5123是生产抗结核肽的方法和用于预防和治疗包含其的分枝杆菌感染的药物组合物。 本发明的组合物对复制/非复制性结核分枝杆菌（包括MDR和XDR菌株）具有高度活性，因此可有效地用作结核病的治疗剂。
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