公开(公告)号：US07361638B2

公开(公告)日：2008-04-22

申请号：US10220750

申请日：2001-12-17

申请人： Jorge Berlanga Acosta ,  Gerardo Enrique Guillen Nieto ,  Diana Garcia Del Barco Herrera ,  Julio Raul Fernandez Masso ,  Mario Pablo Estrada Garcia ,  Isabel Guillen Perez ,  Jose Suarez Alba ,  Rebeca Martinez Rodriguez

发明人： Jorge Berlanga Acosta ,  Gerardo Enrique Guillen Nieto ,  Diana Garcia Del Barco Herrera ,  Julio Raul Fernandez Masso ,  Mario Pablo Estrada Garcia ,  Isabel Guillen Perez ,  Jose Suarez Alba ,  Rebeca Martinez Rodriguez

IPC分类号： A61K38/08 ,  A61K38/18 ,  C07K14/485 ,  C07K14/495

CPC分类号： A61K38/1841 ,  A61K38/08 ,  A61K38/1808 ,  A61K38/25 ,  A61K38/27 ,  A61K2300/00

摘要： This invention relates to a medicine for humans, and particularly to a pharmaceutical combination comprising Epidermal Growth Factor (EGF) and Growth Hormone secretagogue hexapeptide (GHRP) for use in preventing tissue damage due to blood flow suppression by enhancing tissue repair following ischemic damage. The aforementioned combination may be applied as a single pharmaceutical composition. Alternatively, an individual may also receive both EGF and GHRP in a separate manner but within a single therapeutic regime to enhance cellular survival when organs are subjected to blood flow deprivation for a critical period of time. This combination attenuates reactive oxygen species (ROS) formation and its associated cytotoxicity. It is also useful in promoting cellular survival when tissue or organs are exposed to prolonged ischemic periods. The combination is useful as a prophylactic agent in those subjects prone to multiple organ failure (MOF) such as burn victims, multiple trauma patients, hypoxic neonates, acute respiratory distress syndrome patients, and necrotizing enterocolitis patients.

摘要翻译： 本发明涉及用于人的药物，特别涉及包含表皮生长因子（EGF）和生长激素促分泌素六肽（GHRP）的药物组合，用于通过增强缺血性损伤后的组织修复来预防由于血流抑制引起的组织损伤。 上述组合可以作为单一药物组合物使用。 或者，个体也可以以单独的方式接受EGF和GHRP，但是在单一治疗方案内，以便当器官在关键时间段内遭受血流剥夺时增强细胞存活。 这种组合减弱活性氧（ROS）形成及其相关的细胞毒性。 当组织或器官暴露于长时间缺血期时，它也可促进细胞存活。 该组合在易受多器官功能衰竭（MOF）的受试者，如烧伤受试者，多发性创伤患者，缺氧新生儿，急性呼吸窘迫综合征患者和坏死性小肠结肠炎患者中的预防剂是有用的。

公开(公告)号：US20090221512A1

公开(公告)日：2009-09-03

申请号：US12281018

申请日：2007-02-23

申请人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillen Nieto ,  Jose Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

发明人： Jorge Berlanga Acosta ,  Danay Cibrian Vera ,  Diana Garcia Del Barco Herrera ,  Gerardo Enrique Guillen Nieto ,  Jose Suarez Alba ,  Ernesto Lopez Mola ,  Manuel Selman-Housein Sosa ,  Mariela Vazquez Castillo

IPC分类号： A61K38/08

CPC分类号： A61K38/05 ,  A61K38/08 ,  A61K38/25

摘要： The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

摘要翻译： 本发明涉及使用作为药物组合物的一部分反复施用的促分泌素肽，其用于预防和消除病理性纤维化物质在诸如肝，肺，食管，小肠，肾脏，血管等脏器的实质组织中的沉积 ，关节和其他全身形式的皮肤纤维化的任何发病机制。 此外，这些肽预防和消除了在脑，小脑，血管，肝，肠，肾，脾脏，胰腺，关节和皮肤等中的任何相应的化学形式和组织表现的淀粉样和透明物质的沉积。 通过这种方式，校正由这些沉积产生的细胞，组织和器官功能障碍。 本发明的肽被渗透或局部应用，有助于预防和消除作为烧伤和其它皮肤创伤后遗症的皮肤中的瘢痕疙瘩和肥厚性瘢痕。

公开(公告)号：US20090171069A1

公开(公告)日：2009-07-02

申请号：US11663603

申请日：2005-09-22

申请人： Maria del Carmen Dominguez Horta ,  Gabriel Ramon Padron Palomares ,  Nelia Lopez Marin ,  Norailys Lorenzo Perez ,  Ariana Barbera Betancourt ,  Ariadna Hernandez Garcia ,  Vivian Morera Cordova ,  Carelia Cosme Diaz ,  Nelson J. Merino Garcia ,  Ariel Vazquez Bonachea ,  Jose Suarez Alba

发明人： Maria del Carmen Dominguez Horta ,  Gabriel Ramon Padron Palomares ,  Nelia Lopez Marin ,  Norailys Lorenzo Perez ,  Ariana Barbera Betancourt ,  Ariadna Hernandez Garcia ,  Vivian Morera Cordova ,  Carelia Cosme Diaz ,  Nelson J. Merino Garcia ,  Ariel Vazquez Bonachea ,  Jose Suarez Alba

IPC分类号： C07K14/00 ,  C07K7/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00

摘要： Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.

摘要翻译： 构成T细胞表位的人类热休克蛋白的肽，以及它们衍生的肽，在与MHC分子的接触位点被修饰，可用于诱导外周耐受机制，特别是无反应机制 或由风湿性关节炎患者的调节性T细胞的克隆介导。 本发明还涉及包含这些肽用于治疗类风湿关节炎的药物组合物。