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10 条记录 (耗时 0.027 秒)

    Ortho and thio-ortho ester polymer
    2.
    发明授权
    Ortho and thio-ortho ester polymer 失效
    正辛酯和硫代原酸酯聚合物

    公开(公告)号：US5013821A

    公开(公告)日：1991-05-07

    申请号：US348059

    申请日：1989-06-15

    申请人： Jorge Heller ,  Steve Y. W. Ng ,  Donald W. H. Penhale

    发明人： Jorge Heller ,  Steve Y. W. Ng ,  Donald W. H. Penhale

    IPC分类号： A61K9/20 ,  C08G75/00

    CPC分类号： C08G75/00 ,  A61K9/204

    摘要： Biodegradable ortho ester polymers based on mono- and poly-thiols are provided that are useful for making biodegradable sustained release agent dispensers and which contain at least one of the mer units (I), (II), (III) or (IV) ##STR1## wherein X is a quadrivalent organic grouping, A and B are independently selected from the group consisting of hydrogen and lower alkyl, and R is hydrocarbyl or oxyhydrocarbyl of 1 to 14 carbon atoms, if oxyhydrocarbyl, containing 1 to 4 oxy groups, and may be either aliphatic or aryl, unsubstituted or substituted with one or more lower alkyl, amino, nitro or halogen moieties.

    摘要翻译： 提供了基于单硫代硫醇和多硫醇的可生物降解的原酸酯聚合物，其可用于制备可生物降解的持续释放剂分配器，并且其含有至少一种mer单元（I），（II），（III）或（IV） （I）其中X是四价有机基团，A和B独立地选自氢和低级烷基，R是 烃基或含1至14个碳原子的氧代烃基，如果是含有1-4个氧基的羟基烃基，并且可以是未取代的或被一个或多个低级烷基，氨基，硝基或卤素部分取代的脂族或芳基。

    Polymers containing carboxy-ortho ester and ortho ester linkages
    3.
    发明授权
    Polymers containing carboxy-ortho ester and ortho ester linkages 失效
    含羧基原酸酯和原酸酯键的聚合物

    公开(公告)号：US4946931A

    公开(公告)日：1990-08-07

    申请号：US366125

    申请日：1989-06-14

    申请人： Jorge Heller ,  Steve Y. W. Ng ,  Donald W. H. Penhale

    发明人： Jorge Heller ,  Steve Y. W. Ng ,  Donald W. H. Penhale

    IPC分类号： A61K9/20 ,  C08G63/00 ,  C08G63/66

    CPC分类号： C08G63/005 ,  A61K9/204 ,  C08G63/66 ,  Y10S514/866 ,  Y10S514/95 ,  Y10S514/964

    摘要： Polymers are provided that are useful for making biodegradable sustained release agent dispensers and which contain at least one of the following mer units (I) and (II) ##STR1## wherein X is a quadrivalent organic grouping, A and B are hydrogen or lower alkyl, and R is hydrocarbyl or oxyhydrocarbyl of 1 to 14 carbon atoms and, if oxyhydrocarbyl, containing 1 to 4 oxy groups, and may be either aliphatic or aryl, unsubstituted or substituted with one or more lower alkyl, amino, nitro or halogen moieties. Methods of synthesizing the novel polymers are also provided, as biodegradable beneficial agent dispensers prepared using the novel polymers.

    摘要翻译： 提供聚合物，其可用于制备可生物降解的持续释放剂分配器并且其含有以下mer单元（I）和（II）中的至少一种：其中X是四价有机基团 A和B为氢或低级烷基，R为1至14个碳原子的烃基或氧代烃基，如果是含有1至4个氧基的氧代烃基，并且可以是未取代的或被一个或多个低级烷基取代的脂族或芳基 烷基，氨基，硝基或卤素部分。 还提供了合成新型聚合物的方法，作为使用新型聚合物制备的可生物降解的有益剂分配器。

    Bioerodible polymers for solid controlled release pharmaceutical compositions
    4.
    发明授权
    Bioerodible polymers for solid controlled release pharmaceutical compositions 失效
    用于固体控释药物组合物的生物可降解聚合物

    公开(公告)号：US5461140A

    公开(公告)日：1995-10-24

    申请号：US153537

    申请日：1993-11-15

    申请人： Jorge Heller ,  Steve Y. W. Ng

    发明人： Jorge Heller ,  Steve Y. W. Ng

    IPC分类号： A61K9/20 ,  C08G65/34

    CPC分类号： A61K9/204 ,  C08G65/34

    摘要： Bioerodible ortho ester polymers useful for preparing solid form bioerodible pharmaceutical compositions such as pellets, capsules, suppositories and the like are provided. A novel synthetic method for preparing the polymers is provided as well as is a novel triol reactant. Synthesis involves a one-step reaction between a monomeric ortho ester and a triol. The pharmaceutical compositions of the invention are useful for the controlled release of therapeutic agents, and may be administered for a variety of purposes.

    摘要翻译： 提供了可用于制备固体形式的生物可腐蚀的药物组合物如颗粒，胶囊，栓剂等的生物可蚀解的原酸酯聚合物。 提供了一种制备聚合物的新型合成方法，并且是一种新的三醇反应物。 合成涉及单体原酸酯和三醇之间的一步反应。 本发明的药物组合物可用于治疗剂的受控释放，并且可以用于各种目的。

    Bioerodible polymers useful for the controlled release of therapeutic agents
    7.
    发明授权
    Bioerodible polymers useful for the controlled release of therapeutic agents 失效
    可用于治疗剂受控释放的生物可分解聚合物

    公开(公告)号：US5030457A

    公开(公告)日：1991-07-09

    申请号：US400532

    申请日：1989-08-28

    申请人： Steve Y. W. Ng ,  Jorge Heller

    发明人： Steve Y. W. Ng ,  Jorge Heller

    IPC分类号： A61K9/20 ,  A61K47/34 ,  C08G65/34

    CPC分类号： A61K47/34 ,  A61K9/204 ,  C08G65/34

    摘要： Bioerodible ortho ester polymers useful for preparing soft form bioerodible pharmaceutical compositions such as ointments, creams, gels and the like are provided. A novel synthetic method for preparing the polymers is provided as well. Synthesis involves a one-step reaction between a monomeric ortho ester and a triol. The pharmaceutical compositions of the invention are useful for the controlled release of therapeutic agents, and may be administered for a variety of purposes, such as for the treatment of deep wounds, including burns, and for the treatment of periodontal disease.

    摘要翻译： 提供了可用于制备软形式可生物腐蚀性药物组合物如软膏，霜剂，凝胶等的生物可蚀性原酸酯聚合物。 还提供了制备聚合物的新型合成方法。 合成涉及单体原酸酯和三醇之间的一步反应。 本发明的药物组合物可用于治疗剂的受控释放，并且可以用于各种目的，例如用于治疗深部伤口，包括烧伤和用于治疗牙周病。

    Water-soluble fast polymeric black colorant, its preparation and use in dyes and inks
    8.
    发明授权
    Water-soluble fast polymeric black colorant, its preparation and use in dyes and inks 失效
    水溶性快聚合黑色着色剂，其制备和用于染料和油墨

    公开(公告)号：US4375357A

    公开(公告)日：1983-03-01

    申请号：US271913

    申请日：1981-06-09

    申请人： Robert E. Wingard, Jr. ,  Steve Y. W. Ng ,  Sally A. Swanson

    发明人： Robert E. Wingard, Jr. ,  Steve Y. W. Ng ,  Sally A. Swanson

    IPC分类号： C09B69/10

    CPC分类号： C09B69/106 ,  Y10S8/919

    摘要： A family of polymeric black colorants is disclosed. The subject colorants are composed of an organic polymer backbone comprised of a plurality of aromatic rings from which depend via azo groups a plurality of chromophore units having the structure ##STR1## wherein M is hydrogen or preferably a cation. These polymeric colorants are water-soluble, and noncrystalline and form dyes and inks that are fast to paper stock.

    摘要翻译： 公开了一系列聚合物黑色着色剂。 主题着色剂由多个芳环构成的有机聚合物主链组成，其中通过偶氮基取代多个具有结构“IMAGE”的发色团单元，其中M为氢或优选为阳离子。 这些聚合物着色剂是水溶性的，非结晶的，并且形成了对纸料快的染料和油墨。

    Polymeric N-substituted maleimide antioxidants
    9.
    发明授权
    Polymeric N-substituted maleimide antioxidants 失效
    聚合N-取代的马来酰亚胺抗氧化剂

    公开(公告)号：US4078091A

    公开(公告)日：1978-03-07

    申请号：US642038

    申请日：1975-12-18

    申请人： James A. Dale ,  Steve Y. W. Ng

    发明人： James A. Dale ,  Steve Y. W. Ng

    IPC分类号： C11B5/00 ,  A23D5/04

    CPC分类号： C11B5/0057

    摘要： N-substituted maleimide polymers comprising the recurring structural units: ##STR1## wherein R and R' independently are lower alkyl groups of from 1 to 5 carbon atoms and n is an integer of from about 2 to about 2,000, are disclosed. Their preparation as well as the preparation of their monomer precursors and the preferred use of the polymers as antioxidants, particularly nonabsorbable food antioxidants, are also disclosed.

    摘要翻译： 包含重复结构单元的N-取代的马来酰亚胺聚合物：其中R和R'独立地为1至5个碳原子的低级烷基且n为约2至约2,000的整数。 还公开了它们的制备以及其单体前体的制备和聚合物作为抗氧化剂，特别是不可吸收的食品抗氧化剂的优选用途。

    Polymeric N-substituted maleimide antioxidants
    10.
    发明授权
    Polymeric N-substituted maleimide antioxidants 失效
    聚合N-取代的马来酰亚胺抗氧化剂

    公开(公告)号：US4205151A

    公开(公告)日：1980-05-27

    申请号：US821163

    申请日：1977-08-02

    申请人： James A. Dale ,  Steve Y. W. Ng

    发明人： James A. Dale ,  Steve Y. W. Ng

    IPC分类号： A23L3/3526 ,  C08F22/40 ,  C11B5/00 ,  C08F122/40 ,  C08F4/04 ,  C08F222/40

    CPC分类号： A23L3/3526 ,  C08F22/40 ,  C11B5/0057

    摘要： N-substituted maleimide polymers comprising the recurring structural units: ##STR1## wherein R and R' independently are lower alkyl groups of from 1 to 5 carbon atoms and n is an integer of from about 2 to about 2,000, are disclosed. Their preparation as well as the preparation of their monomer precursors and the preferred use of the polymers as antioxidants, particularly nonabsorbable food antioxidants, are also disclosed.

    摘要翻译： 包含重复结构单元的N-取代的马来酰亚胺聚合物：其中R和R'独立地为1至5个碳原子的低级烷基且n为约2至约2,000的整数。 还公开了它们的制备以及其单体前体的制备和聚合物作为抗氧化剂，特别是不可吸收的食品抗氧化剂的优选用途。