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公开(公告)号：US20130178537A1
公开(公告)日：2013-07-11
申请号：US13543086
申请日：2012-07-06
CPC分类号： A61K31/05 , A23L33/105 , A23V2002/00 , A61K8/347 , A61K8/97 , A61K36/63 , A61K2236/39 , A61K2800/10 , A61Q19/00 , A61K2300/00 , A23V2200/02 , A23V2250/2131 , A23V2250/2132 , A23V2300/14
摘要： Hydroxytyrosol extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by acid hydrolysis and purification on resin columns eluted with water contains hydroxytyrosol and tyrosol, is free from sugars, has a residual content of Benzo[a]pyrene that is less than 2 microg/Kg (weight BaP/weight of extract as dry matter), containing a weight ratio of hydroxytyrosol to hydroxymethylfurfural of between 45:1 and 10000:1, and the content of hydroxytyrosol in the extract is at least 0.5% (w/w) with purity of at least 40% (by HPLC 280 nm).
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2.发明申请PROCESS AND APPARATUS FOR THE PRODUCTION OF HYDROXYTYROSOL CONTAINING EXTRACT FROM OLIVES AND SOLIDS CONTAINING RESIDUES OF OLIVE OIL EXTRACTION 有权含有含橄榄油萃取残留物的OLIVES和固体含有羟考菌素的提取物的方法和装置公开(公告)号：US20100160690A1
公开(公告)日：2010-06-24
申请号：US12524603
申请日：2008-01-25
CPC分类号： B01J19/18 , B01J2219/00006 , B01J2219/00094 , C07C37/004 , C07C39/11
摘要： Hydroxytyrosol is extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by carrying out acid hydrolysis at a temperature within the range of 110° C. to 140° C. and at a pH within the range of 1.0 to 6.0, and by purifying the obtained solution on a column containing acid activated anion exchange resins, and a column containing an adsorbent non-ionic resin; both columns being eluted with water to recover the hydroxytyrosol.
摘要翻译： 提取橄榄油后，从橄榄和/或橄榄的固体残渣中提取羟基酪蛋白，通过在110℃至140℃的温度范围内进行酸水解，并在pH范围内 1.0至6.0，并将所得溶液纯化在含有酸活化阴离子交换树脂的柱和含有吸附剂非离子树脂的柱上; 两个柱用水洗脱以回收羟基酪醇。
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3.发明申请POMEGRANATE EXTRACTS, NUTRITIONAL PRODUCTS CONTAINING THEM AND THEIR USES 审中-公开POMEGRANATE提取物，包含它们的营养产品及其用途公开(公告)号：US20100210586A1
公开(公告)日：2010-08-19
申请号：US12676719
申请日：2008-09-05
申请人： Jose A. Lopez Mas , Sergio A. Streitenberger , Marcos Penalver Mellado , Yolanda Pedreno Lopez , Pedro Martinez Ortiz
发明人： Jose A. Lopez Mas , Sergio A. Streitenberger , Marcos Penalver Mellado , Yolanda Pedreno Lopez , Pedro Martinez Ortiz
CPC分类号： A23C9/152 , A23K20/121 , A23K50/45 , A23L2/02 , A23L13/03 , A23L13/72 , A23L17/75 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K2300/00 , A23V2250/2132 , A23V2250/21 , A23V2200/3262 , A23V2200/326
摘要： The present invention relates to new pomegranate extracts, combined or not with soluble fiber, compositions free of any kind of organic solvent, soluble in cold water in high concentration, with very low sugar content and specially standardized to punicalagins, and its addition to foods to provide nutritional products and beverages with increased antioxidant capacity to be used as a source of punicalagins for preventing or treating cardiovascular diseases, plaque build-up in the arteries, arterial hypertension, and metabolic syndrome.
摘要翻译： 本发明涉及与可溶性纤维组合或不结合的新石榴提取物，不含任何种类的有机溶剂的组合物，可溶于高浓度的冷水中，糖含量非常低，并且特别标准化为防腐剂，并且其添加到食品中 提供具有增加的抗氧化能力的营养产品和饮料作为预防或治疗心血管疾病，动脉斑块积聚，动脉高血压和代谢综合征的惩罚剂的来源。
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4.发明授权Hydroxytrosol containing extract obtained from olives and solids containing residues of olive oil extraction 有权含有羟基溶胶的提取物由橄榄和含有橄榄油提取残留物的固体获得公开(公告)号：US08968811B2
公开(公告)日：2015-03-03
申请号：US13543086
申请日：2012-07-06
申请人： Jose A. Lopez Mas , Sergio A. Streitenberger , Marcos Peñ{tilde over ( )}alver Mellado , Pedro Martinez Ortiz
发明人： Jose A. Lopez Mas , Sergio A. Streitenberger , Marcos Peñ{tilde over ( )}alver Mellado , Pedro Martinez Ortiz
CPC分类号： A61K31/05 , A23L33/105 , A23V2002/00 , A61K8/347 , A61K8/97 , A61K36/63 , A61K2236/39 , A61K2800/10 , A61Q19/00 , A61K2300/00 , A23V2200/02 , A23V2250/2131 , A23V2250/2132 , A23V2300/14
摘要： Hydroxytyrosol extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by acid hydrolysis and purification on resin columns eluted with water contains hydroxytyrosol and tyrosol, is free from sugars, has a residual content of Benzo[a]pyrene that is less than 2 microg/Kg (weight BaP/weight of extract as dry matter), containing a weight ratio of hydroxytyrosol to hydroxymethylfurfural of between 45:1 and 10000:1, and the content of hydroxytyrosol in the extract is at least 0.5% (w/w) with purity of at least 40% (by HPLC 280 nm).
摘要翻译： 在橄榄油提取橄榄和/或橄榄固体残渣后提取的羟基酪醇，通过酸性水解和纯化在含有羟基酪醇和酪醇的树脂柱上的树脂柱上，不含糖，具有苯并[a] 芘的含量小于2微克/ Kg（重量BaP /干物质提取物的重量），羟基酪醇与羟甲基糠醛的重量比为45:1至10000:1，提取物中羟基酪醇的含量至少为 纯度为至少40％（通过HPLC 280nm）的0.5％（w / w）。
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5.发明授权Process and apparatus for the production of hydroxytyrosol containing extract from olives and solids containing residues of olive oil extraction 有权用于生产含有橄榄油提取物的橄榄和固体含有残留物的含羟基酪醇的提取物的方法和装置公开(公告)号：US08236993B2
公开(公告)日：2012-08-07
申请号：US12524603
申请日：2008-01-25
CPC分类号： B01J19/18 , B01J2219/00006 , B01J2219/00094 , C07C37/004 , C07C39/11
摘要： Hydroxytyrosol is extracted from olives and/or from the solid residues of olives after the extraction of olive oil, by carrying out acid hydrolysis at a temperature within the range of 110° C. to 140° C. and at a pH within the range of 1.0 to 6.0, and by purifying the obtained solution on a column containing acid activated anion exchange resins, and a column containing an adsorbent non-ionic resin; both columns being eluted with water to recover the hydroxytyrosol.
摘要翻译： 提取橄榄油后，从橄榄和/或橄榄的固体残渣中提取羟基酪蛋白，通过在110℃至140℃的温度范围内进行酸水解，并在pH范围内 1.0至6.0，并将所得溶液纯化在含有酸活化阴离子交换树脂的柱和含有吸附剂非离子树脂的柱上; 两个柱用水洗脱以回收羟基酪醇。
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公开(公告)号：US09155708B2
公开(公告)日：2015-10-13
申请号：US13123295
申请日：2008-10-10
申请人： Sergio A. Streitenberger , Marcos Peñalver Mellado , José A. López Más , Yolanda Pedreño López , Juan P. Sola González , Pedro Martínez Ortiz , Victoriano Mulero Mendez , Francisco Roca Soler , Jorge Galindo Villegas
发明人： Sergio A. Streitenberger , Marcos Peñalver Mellado , José A. López Más , Yolanda Pedreño López , Juan P. Sola González , Pedro Martínez Ortiz , Victoriano Mulero Mendez , Francisco Roca Soler , Jorge Galindo Villegas
IPC分类号： A61K38/00 , A61K38/17 , A61K38/19 , C12N1/19 , C12N15/12 , A61K9/50 , A23K1/00 , A23K1/16 , A23K1/18
CPC分类号： A61K9/5026 , A23K20/147 , A23K40/30 , A23K50/80 , A61K38/1706 , A61K38/191
摘要： An orally administrable immunostimulant product comprises a microencapsulated cytokine and an enteric protection polymer to protect the cytokine, the cytokine is a fish, mollusc or crustacean cytokine, preferably a recombinant cytokine such as tumor necrosis factor α (TNFα) over-expressed in a host microorganism.
摘要翻译： 口服给药的免疫刺激剂产品包含微胶囊化的细胞因子和保护细胞因子的肠溶保护聚合物，细胞因子是鱼，软体动物或甲壳动物细胞因子，优选重组细胞因子如宿主微生物中过表达的肿瘤坏死因子α（TNFα） 。
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7.发明申请FORTIFICATION OF NUTRITIONAL PRODUCTS WITH OLIVE EXTRACTS CONTAINING HYDROXYTYROSOL AND HYDROXYTYROSOL FORTIFIED NUTRITIONAL PRODUCTS. 审中-公开通过含有羟肟酸和羟基吡咯烷酮营养营养产品的橄榄提取物来营养营养产品。公开(公告)号：US20100184868A1
公开(公告)日：2010-07-22
申请号：US12669840
申请日：2008-07-23
CPC分类号： A61K31/05 , A23D7/005 , A23D7/0056 , A23D9/007 , A23L33/105 , A23V2002/00 , A61K36/63 , C11B5/0035 , C11B5/0085 , A23V2200/326 , A23V2250/21 , A23V2250/2132 , A23V2200/02
摘要： The present invention relates to nutritional products containing hydroxytyrosol, particularly fond products (i.e: fortified edible oils and fortified edible oil-containing products) and dietary supplements (i.e.: soft gel capsules containing fortified edible oils) with increased antioxidant capacity to be used as a source of hydroxytyrosol for preventing or treating cardiovascular diseases, plaque build-up in the arteries, arterial hypertension, and metabolic syndrome, thanks to the nutritional supply of an hydroxytyrosol rich composition.
摘要翻译： 本发明涉及具有增加的抗氧化能力的羟基酪醇的营养产品，特别是喜爱的产品（即，强化的食用油和强化的食用含油产品）和膳食补充剂（即：含强化食用油的软胶囊） 由于富含羟基酪氨酸的组合物的营养供应，用于预防或治疗心血管疾病，动脉斑块积聚，动脉高血压和代谢综合征的羟基酪醇的来源。
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8.发明申请ORALLY ADMINISTRABLE IMMUNOSTIMULANT PRODUCT FOR AQUACULTURE 有权ORALLY ADMINISTRLY IMMUNOSTIMULANT PRODUCT for AQUACULTURE公开(公告)号：US20110225660A1
公开(公告)日：2011-09-15
申请号：US13123295
申请日：2008-10-10
申请人： Sergio A. Streitenberger , Marcos Peñalver Mellado , José A. López Más , Yolanda Pedreño López , Juan P. Sola González , Pedro Martínez Ortiz , Victoriano Mulero Mendez , Francisco Roca Soler , Jorge Galindo Villegas
发明人： Sergio A. Streitenberger , Marcos Peñalver Mellado , José A. López Más , Yolanda Pedreño López , Juan P. Sola González , Pedro Martínez Ortiz , Victoriano Mulero Mendez , Francisco Roca Soler , Jorge Galindo Villegas
CPC分类号： A61K9/5026 , A23K20/147 , A23K40/30 , A23K50/80 , A61K38/1706 , A61K38/191
摘要： An orally administrable immunostimulant product comprises a microencapsulated cytokine and an enteric protection polymer to protect the cytokine, the cytokine is a fish, mollusc or crustacean cytokine, preferably a recombinant cytokine such as tumor necrosis factor α (TNFα) over-expressed in a host microorganism.
摘要翻译： 口服给药的免疫刺激剂产品包含微胶囊化的细胞因子和保护细胞因子的肠溶保护聚合物，细胞因子是鱼，软体动物或甲壳动物细胞因子，优选重组细胞因子如宿主微生物中过表达的肿瘤坏死因子α（TNFα） 。
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