公开(公告)号：US20050267201A1

公开(公告)日：2005-12-01

申请号：US11165896

申请日：2005-06-24

申请人： Jose Gutierrez-Rocca ,  Janice Cacace ,  Sami Selim ,  Robert Testman ,  J. Rutledge

发明人： Jose Gutierrez-Rocca ,  Janice Cacace ,  Sami Selim ,  Robert Testman ,  J. Rutledge

IPC分类号： A61K9/10 ,  A61F2/02 ,  A61K9/107 ,  A61K9/20 ,  A61K9/48 ,  A61K9/64 ,  A61K31/335 ,  A61K31/337 ,  A61K38/13 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/40 ,  A61K47/44 ,  A61P1/16 ,  A61P1/18 ,  A61P13/08 ,  A61P13/12 ,  A61P33/06 ,  A61P35/00

CPC分类号： A61K9/4858 ,  A61K9/1075 ,  A61K9/4866 ,  A61K31/335 ,  A61K31/337 ,  A61K38/13 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/40 ,  Y02A50/411 ,  A61K2300/00

摘要： Pharmaceutical compositions for oral administration to mammalian subjects comprise a taxane or taxane derivative (e.g., paclitaxel or docetaxel) as active ingredient and a vehicle comprising at least 30% by weight of a carrier for the taxane, said carrier having an HLB value of at least about 10. The compositions may also comprise 0-70% of a viscosity-reducing co-solubilizer. The compositions may be incorporated into conventional oral pharmaceutical dosage forms, or can be in the form of a two-part medicament wherein the first part includes the taxane in a solubilizing vehicle and the second part comprises a carrier for the taxane to promote oral absorption. Methods of treatment of taxane-responsive disease conditions employing the novel compositions are also disclosed, whereby the compositions can be administered alone or in association with an oral bioavailability enhancing agent.

公开(公告)号：US20100022634A1

公开(公告)日：2010-01-28

申请号：US12456300

申请日：2009-06-15

申请人： Steven Holmes ,  Janice Cacace

发明人： Steven Holmes ,  Janice Cacace

IPC分类号： A61K31/35 ,  A61P3/00

CPC分类号： A61K31/35 ,  A23K20/195 ,  A23K40/10 ,  A23K50/10

摘要： An animal feed additive composition comprises an effective amount of a laidlomycin, a carrier, magnesium sulfate, and silicon dioxide. Other embodiments include methods of making the animal feed additive compositions, and the use of a laidlomycin in the manufacture of an animal feed additive for increasing the efficiency of feed utilization and rate of weight gain in domestic animals.

摘要翻译： 动物饲料添加剂组合物包含有效量的布洛霉素，载体，硫酸镁和二氧化硅。 其他实施方案包括制备动物饲料添加剂组合物的方法，以及在生产动物饲料添加剂中使用布洛霉素以提高饲料利用效率和家畜体重增加率的方法。

公开(公告)号：US20050027011A1

公开(公告)日：2005-02-03

申请号：US10746324

申请日：2003-12-23

申请人： Chih-Ming Chen ,  Boyong Li ,  Janice Cacace

发明人： Chih-Ming Chen ,  Boyong Li ,  Janice Cacace

IPC分类号： A61K9/14 ,  A61K9/16 ,  A61K9/20 ,  A61K9/28 ,  A61K31/135 ,  A61K31/4525 ,  A61K31/137

CPC分类号： A61K31/135 ,  A61K9/146 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/2866 ,  A61K31/4525

摘要： A process for preparing amorphous paroxetine hydrochloride or sertraline hydrochloride is provided, which comprises preparing a solution in which paroxetine hydrochloride or sertraline hydrochloride and a water-soluble polymer are dissolved in a co-solvent of a volatile organic solvent and water. Said solution is dried to obtain a composition comprising amorphous paroxetine hydrochloride or sertraline hydrochloride and the water-soluble matrix.

摘要翻译： 本发明提供了制备无定形帕罗西汀盐酸盐或舍曲林盐酸盐的方法，其包括制备其中将帕罗西汀盐酸盐或舍曲林盐酸盐和水溶性聚合物溶于挥发性有机溶剂和水的共溶剂中的溶液。 将所述溶液干燥以获得包含无定形帕罗西汀盐酸盐或舍曲林盐酸盐和水溶性基质的组合物。

公开(公告)号：US09149456B2

公开(公告)日：2015-10-06

申请号：US12456300

申请日：2009-06-15

申请人： Steven Holmes ,  Janice Cacace

发明人： Steven Holmes ,  Janice Cacace

IPC分类号： A61K31/35 ,  A23K1/00 ,  A23K1/17 ,  A23K1/18

CPC分类号： A61K31/35 ,  A23K20/195 ,  A23K40/10 ,  A23K50/10

摘要： An animal feed additive composition comprises an effective amount of a laidlomycin, a carrier, magnesium sulfate, and silicon dioxide. Other embodiments include methods of making the animal feed additive compositions, and the use of a laidlomycin in the manufacture of an animal feed additive for increasing the efficiency of feed utilization and rate of weight gain in domestic animals.

摘要翻译： 动物饲料添加剂组合物包含有效量的布洛霉素，载体，硫酸镁和二氧化硅。 其他实施方案包括制备动物饲料添加剂组合物的方法，以及在生产动物饲料添加剂中使用布洛霉素以提高饲料利用效率和家畜体重增加率的方法。

公开(公告)号：US06720003B2

公开(公告)日：2004-04-13

申请号：US09785040

申请日：2001-02-16

申请人： Chih-Ming Chen ,  Boyong Li ,  Janice Cacace

发明人： Chih-Ming Chen ,  Boyong Li ,  Janice Cacace

IPC分类号： A61K920

CPC分类号： A61K31/135 ,  A61K9/146 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2054 ,  A61K9/2866 ,  A61K31/4525

摘要： A process for preparing amorphous paroxetine hydrochloride or sertraline hydrochloride is provided, which comprises preparing a solution in which paroxetine hydrochloride or sertraline hydrochloride and a water-soluble polymer are dissolved in a co-solvent of a volatile organic solvent and water. Said solution is dried to obtain a composition comprising amorphous paroxetine hydrochloride or sertraline hydrochloride and the water-soluble matrix.

摘要翻译： 本发明提供了制备无定形帕罗西汀盐酸盐或舍曲林盐酸盐的方法，其包括制备其中将帕罗西汀盐酸盐或舍曲林盐酸盐和水溶性聚合物溶于挥发性有机溶剂和水的共溶剂中的溶液。 将所述溶液干燥以获得包含无定形帕罗西汀盐酸盐或舍曲林盐酸盐和水溶性基质的组合物。