公开(公告)号：US20080274968A1

公开(公告)日：2008-11-06

申请号：US12104429

申请日：2008-04-16

申请人： Jose Javier Gomez Roman ,  Maria Pilar Saenz Jimenez ,  Jorge Ochoa Garay ,  Jokin Del Amo Iribarren ,  Cristina Sanz Ibayondo ,  Corina Junquera Sanchez-Vallejo ,  Laureano Simon Buela ,  Antonio Martinez Martinez ,  Jose Fernando Val Bernal ,  Jorge Cuevas Gonzalez

发明人： Jose Javier Gomez Roman ,  Maria Pilar Saenz Jimenez ,  Jorge Ochoa Garay ,  Jokin Del Amo Iribarren ,  Cristina Sanz Ibayondo ,  Corina Junquera Sanchez-Vallejo ,  Laureano Simon Buela ,  Antonio Martinez Martinez ,  Jose Fernando Val Bernal ,  Jorge Cuevas Gonzalez

IPC分类号： A61K38/16 ,  A61K48/00 ,  C12Q1/68 ,  C12N15/00 ,  G01N33/574 ,  A61P35/00

CPC分类号： G01N33/57438 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/71 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  Y10T436/143333

摘要： The present invention refers to an in vitro method for detecting the presence of renal cancer in an individual, for determining the stage, malignancy or severity of said carcinoma in the individual or for monitoring the effect of the therapy administered to an individual having said cancer; to the search, identification, development and assessment of the efficacy of compounds for therapy for said cancer in an attempt to develop new drugs; as well as to agents inducing Plexin-131 protein expression and/or activity, or to agents inhibiting the effects of Plexin-B1 protein expression and/or activity repression.

摘要翻译： 本发明涉及用于检测个体中肾癌的存在的体外方法，用于确定个体中所述癌症的阶段，恶性或严重程度，或用于监测施用于具有所述癌症的个体的治疗效果; 用于搜索，鉴定，开发和评估化合物治疗所述癌症以试图开发新药的功效; 以及诱导Plexin-131蛋白表达和/或活性的药剂，或抑制Plexin-B1蛋白表达和/或活性抑制作用的药剂。

公开(公告)号：US20110098191A1

公开(公告)日：2011-04-28

申请号：US12877092

申请日：2010-09-07

申请人： Jose Javier Gomez Roman ,  Maria Pilar Saenz Jimenez ,  Jorge Ochoa Garay ,  Jokin Del Amo Iribarren ,  Cristina Sanz Ibayondo ,  Corina Junquera Sanchez-Vallejo ,  Laureano Simon Buela ,  Antonio Martinez Martinez ,  Jose Fernando Val Bernal ,  Jorge Cuevas Gonzalez

发明人： Jose Javier Gomez Roman ,  Maria Pilar Saenz Jimenez ,  Jorge Ochoa Garay ,  Jokin Del Amo Iribarren ,  Cristina Sanz Ibayondo ,  Corina Junquera Sanchez-Vallejo ,  Laureano Simon Buela ,  Antonio Martinez Martinez ,  Jose Fernando Val Bernal ,  Jorge Cuevas Gonzalez

IPC分类号： C40B30/04 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/566

CPC分类号： G01N33/57438 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/71 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  Y10T436/143333

摘要： The present invention refers to an in vitro method for detecting the presence of renal cancer in an individual, for determining the stage, malignancy or severity of said carcinoma in the individual or for monitoring the effect of the therapy administered to an individual having said cancer; to the search, identification, development and assessment of the efficacy of compounds for therapy for said cancer in an attempt to develop new drugs; as well as to agents inducing Plexin-131 protein expression and/or activity, or to agents inhibiting the effects of Plexin-B1 protein expression and/or activity repression.

摘要翻译： 本发明涉及用于检测个体中肾癌的存在的体外方法，用于确定个体中所述癌症的阶段，恶性或严重程度，或用于监测施用于具有所述癌症的个体的治疗效果; 用于搜索，鉴定，开发和评估化合物治疗所述癌症以试图开发新药的功效; 以及诱导Plexin-131蛋白表达和/或活性的药剂，或抑制Plexin-B1蛋白表达和/或活性抑制作用的药剂。

公开(公告)号：US20080015143A1

公开(公告)日：2008-01-17

申请号：US10563025

申请日：2004-06-30

申请人： Jose Javier Gomez Roman ,  Maria Pilar Saenz Jimenez ,  Jorge Ochoa Garay ,  Jokin Del Amo Iribarren ,  Cristina Sanz Ibayondo ,  Corina Junquera Sanchez-Vallejo ,  Laureano Simon Buela ,  Antonio Martinez Martinez ,  Jose Fernando Val Bernal ,  Jorge Cuevas-Gonzalez

发明人： Jose Javier Gomez Roman ,  Maria Pilar Saenz Jimenez ,  Jorge Ochoa Garay ,  Jokin Del Amo Iribarren ,  Cristina Sanz Ibayondo ,  Corina Junquera Sanchez-Vallejo ,  Laureano Simon Buela ,  Antonio Martinez Martinez ,  Jose Fernando Val Bernal ,  Jorge Cuevas-Gonzalez

IPC分类号： G01N33/574 ,  A61K31/7088 ,  A61K38/16 ,  C12N15/00 ,  G01N33/68 ,  C12Q1/68 ,  G01N33/566

CPC分类号： G01N33/57438 ,  C07K14/4703 ,  C07K14/705 ,  C07K14/71 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/136 ,  Y10T436/143333

摘要： The present invention refers to an in vitro method for detecting the presence of renal cancer in an individual, for determining the stage, malignancy or severity of said carcinoma in the individual or for monitoring the effect of the therapy administered to an individual having said cancer; to the search, identification, development and assessment of the efficacy of compounds for therapy for said cancer in an attempt to develop new drugs; as well as to agents inducing Plexin-131 protein expression and/or activity, or to agents inhibiting the effects of Plexin-B1 protein expression and/or activity repression.

摘要翻译： 本发明涉及用于检测个体中肾癌的存在的体外方法，用于确定个体中所述癌症的阶段，恶性或严重程度，或用于监测施用于具有所述癌症的个体的治疗效果; 用于搜索，鉴定，开发和评估化合物治疗所述癌症以试图开发新药的功效; 以及诱导Plexin-131蛋白表达和/或活性的药剂，或抑制Plexin-B1蛋白表达和/或活性抑制作用的药剂。