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公开(公告)号：US20080274968A1
公开(公告)日：2008-11-06
申请号：US12104429
申请日：2008-04-16
申请人： Jose Javier Gomez Roman , Maria Pilar Saenz Jimenez , Jorge Ochoa Garay , Jokin Del Amo Iribarren , Cristina Sanz Ibayondo , Corina Junquera Sanchez-Vallejo , Laureano Simon Buela , Antonio Martinez Martinez , Jose Fernando Val Bernal , Jorge Cuevas Gonzalez
发明人： Jose Javier Gomez Roman , Maria Pilar Saenz Jimenez , Jorge Ochoa Garay , Jokin Del Amo Iribarren , Cristina Sanz Ibayondo , Corina Junquera Sanchez-Vallejo , Laureano Simon Buela , Antonio Martinez Martinez , Jose Fernando Val Bernal , Jorge Cuevas Gonzalez
CPC分类号： G01N33/57438 , C07K14/4703 , C07K14/705 , C07K14/71 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , Y10T436/143333
摘要： The present invention refers to an in vitro method for detecting the presence of renal cancer in an individual, for determining the stage, malignancy or severity of said carcinoma in the individual or for monitoring the effect of the therapy administered to an individual having said cancer; to the search, identification, development and assessment of the efficacy of compounds for therapy for said cancer in an attempt to develop new drugs; as well as to agents inducing Plexin-131 protein expression and/or activity, or to agents inhibiting the effects of Plexin-B1 protein expression and/or activity repression.
摘要翻译： 本发明涉及用于检测个体中肾癌的存在的体外方法，用于确定个体中所述癌症的阶段，恶性或严重程度，或用于监测施用于具有所述癌症的个体的治疗效果; 用于搜索，鉴定，开发和评估化合物治疗所述癌症以试图开发新药的功效; 以及诱导Plexin-131蛋白表达和/或活性的药剂，或抑制Plexin-B1蛋白表达和/或活性抑制作用的药剂。
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公开(公告)号：US20110098191A1
公开(公告)日：2011-04-28
申请号：US12877092
申请日：2010-09-07
申请人： Jose Javier Gomez Roman , Maria Pilar Saenz Jimenez , Jorge Ochoa Garay , Jokin Del Amo Iribarren , Cristina Sanz Ibayondo , Corina Junquera Sanchez-Vallejo , Laureano Simon Buela , Antonio Martinez Martinez , Jose Fernando Val Bernal , Jorge Cuevas Gonzalez
发明人： Jose Javier Gomez Roman , Maria Pilar Saenz Jimenez , Jorge Ochoa Garay , Jokin Del Amo Iribarren , Cristina Sanz Ibayondo , Corina Junquera Sanchez-Vallejo , Laureano Simon Buela , Antonio Martinez Martinez , Jose Fernando Val Bernal , Jorge Cuevas Gonzalez
IPC分类号： C40B30/04 , C12Q1/68 , G01N33/53 , G01N33/566
CPC分类号： G01N33/57438 , C07K14/4703 , C07K14/705 , C07K14/71 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , Y10T436/143333
摘要： The present invention refers to an in vitro method for detecting the presence of renal cancer in an individual, for determining the stage, malignancy or severity of said carcinoma in the individual or for monitoring the effect of the therapy administered to an individual having said cancer; to the search, identification, development and assessment of the efficacy of compounds for therapy for said cancer in an attempt to develop new drugs; as well as to agents inducing Plexin-131 protein expression and/or activity, or to agents inhibiting the effects of Plexin-B1 protein expression and/or activity repression.
摘要翻译： 本发明涉及用于检测个体中肾癌的存在的体外方法，用于确定个体中所述癌症的阶段，恶性或严重程度，或用于监测施用于具有所述癌症的个体的治疗效果; 用于搜索，鉴定，开发和评估化合物治疗所述癌症以试图开发新药的功效; 以及诱导Plexin-131蛋白表达和/或活性的药剂，或抑制Plexin-B1蛋白表达和/或活性抑制作用的药剂。
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公开(公告)号：US20080015143A1
公开(公告)日：2008-01-17
申请号：US10563025
申请日：2004-06-30
申请人： Jose Javier Gomez Roman , Maria Pilar Saenz Jimenez , Jorge Ochoa Garay , Jokin Del Amo Iribarren , Cristina Sanz Ibayondo , Corina Junquera Sanchez-Vallejo , Laureano Simon Buela , Antonio Martinez Martinez , Jose Fernando Val Bernal , Jorge Cuevas-Gonzalez
发明人： Jose Javier Gomez Roman , Maria Pilar Saenz Jimenez , Jorge Ochoa Garay , Jokin Del Amo Iribarren , Cristina Sanz Ibayondo , Corina Junquera Sanchez-Vallejo , Laureano Simon Buela , Antonio Martinez Martinez , Jose Fernando Val Bernal , Jorge Cuevas-Gonzalez
IPC分类号： G01N33/574 , A61K31/7088 , A61K38/16 , C12N15/00 , G01N33/68 , C12Q1/68 , G01N33/566
CPC分类号： G01N33/57438 , C07K14/4703 , C07K14/705 , C07K14/71 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , Y10T436/143333
摘要： The present invention refers to an in vitro method for detecting the presence of renal cancer in an individual, for determining the stage, malignancy or severity of said carcinoma in the individual or for monitoring the effect of the therapy administered to an individual having said cancer; to the search, identification, development and assessment of the efficacy of compounds for therapy for said cancer in an attempt to develop new drugs; as well as to agents inducing Plexin-131 protein expression and/or activity, or to agents inhibiting the effects of Plexin-B1 protein expression and/or activity repression.
摘要翻译： 本发明涉及用于检测个体中肾癌的存在的体外方法，用于确定个体中所述癌症的阶段，恶性或严重程度，或用于监测施用于具有所述癌症的个体的治疗效果; 用于搜索，鉴定，开发和评估化合物治疗所述癌症以试图开发新药的功效; 以及诱导Plexin-131蛋白表达和/或活性的药剂，或抑制Plexin-B1蛋白表达和/或活性抑制作用的药剂。
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4.发明申请METHODS AND PRODUCTS FOR IN VITRO DIAGNOSIS, IN VITRO PROGNOSIS AND THE DEVELOPMENT OF DRUGS AGAINST INVASIVE CARCINOMAS 有权用于体外诊断，体外预防的方法和产品以及针对入侵性癌症的药物的开发公开(公告)号：US20150362496A1
公开(公告)日：2015-12-17
申请号：US14237682
申请日：2012-08-08
申请人： Luis Barneo Serra , Carmen Garcia Pravia , Juan Ramon De Los Toyos Gonzalez , Marcos Garcia Ocana , Jose Fernando Vazquez Villa , Nelson Fuentes Martinez , Jokin Del Amo Iribarren , Laureano Simon Buela
发明人： Luis Barneo Serra , Carmen Garcia Pravia , Juan Ramon De Los Toyos Gonzalez , Marcos Garcia Ocana , Jose Fernando Vazquez Villa , Nelson Fuentes Martinez , Jokin Del Amo Iribarren , Laureano Simon Buela
IPC分类号： G01N33/574 , C12Q1/68
CPC分类号： G01N33/57484 , C07K16/18 , C07K16/30 , C07K2317/33 , C12Q1/6886 , C12Q2600/118 , G01N33/5011 , G01N33/6881 , G01N33/6887 , G01N2333/78 , G01N2800/56
摘要： The present invention relates to in vitro methods and products for detecting the presence of an invasive carcinoma in an individual, for determining and/or predicting the stage and/or invasiveness of said carcinoma in an individual, or for monitoring the effect of the therapy administered to an individual who has said carcinoma based on col11a1 gene and proCOL11A1 protein expression. The invention also relates to the search for, identification, development and evaluation of the efficacy of compounds for therapy for said carcinoma, for the purpose of developing new medicinal products. The invention also relates to agents inhibiting proCOL11A1 protein expression and/or activity, and/or the effects of this expression.
摘要翻译： 本发明涉及用于检测个体侵袭性癌的存在的体外方法和产品，用于确定和/或预测个体中所述癌的阶段和/或侵袭性，或用于监测施用的治疗的效果 对具有基于col11a1基因和proCOL11A1蛋白表达的癌症的个体。 本发明还涉及为了开发新的药用产品而寻求，鉴定，开发和评估化合物治疗所述癌症的功效。 本发明还涉及抑制proCOL11A1蛋白表达和/或活性的药剂和/或该表达的作用。
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公开(公告)号：US09702879B2
公开(公告)日：2017-07-11
申请号：US14237682
申请日：2012-08-08
申请人： Luis Barneo Serra , Carmen Garcia Pravia , Juan Ramon De Los Toyos Gonzalez , Marcos Garcia Ocana , Jose Fernando Vazquez Villa , Nelson Fuentes Martinez , Jokin Del Amo Iribarren , Laureano Simon Buela
发明人： Luis Barneo Serra , Carmen Garcia Pravia , Juan Ramon De Los Toyos Gonzalez , Marcos Garcia Ocana , Jose Fernando Vazquez Villa , Nelson Fuentes Martinez , Jokin Del Amo Iribarren , Laureano Simon Buela
IPC分类号： G01N33/573 , G01N33/574 , C07K16/18 , C07K16/30 , G01N33/50 , G01N33/68 , C12Q1/68
CPC分类号： G01N33/57484 , C07K16/18 , C07K16/30 , C07K2317/33 , C12Q1/6886 , C12Q2600/118 , G01N33/5011 , G01N33/6881 , G01N33/6887 , G01N2333/78 , G01N2800/56
摘要： The present invention relates to in vitro methods and products for detecting the presence of an invasive carcinoma in an individual, for determining and/or predicting the stage and/or invasiveness of said carcinoma in an individual, or for monitoring the effect of the therapy administered to an individual who has said carcinoma based on col11a1 gene and proCOL11A1 protein expression. The invention also relates to the search for, identification, development and evaluation of the efficacy of compounds for therapy for said carcinoma, for the purpose of developing new medicinal products. The invention also relates to agents inhibiting proCOL11A1 protein expression and/or activity, and/or the effects of this expression.
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