专利检索 ap:("Josef Bencsik" OR "James F. Blake" OR "Nicholas C. Kallan" OR "Ian S. Mtchell" OR "Keith L. Spencer" OR "Dengming Xiao" OR "Rui Xu" OR "Christine Chabot" OR "Steven Do" OR "Jun Liang" OR "Brian Safina" OR "Birong Zhang") AND inv:"Ian S. Mtchell" 第 1 页

1.

发明申请
HYDROXYLATED PYRIMIDYL CYCLOPENTANE AS AKT PROTEIN KINASE INHIBITOR 有权
标题翻译：羟丙基吡咯烷酮作为AKT蛋白激酶抑制剂

公开(公告)号：US20100292244A1

公开(公告)日：2010-11-18

申请号：US12811983

申请日：2009-01-09

申请人： Josef Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mtchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang

发明人： Josef Bencsik , James F. Blake , Nicholas C. Kallan , Ian S. Mtchell , Keith L. Spencer , Dengming Xiao , Rui Xu , Christine Chabot , Steven Do , Jun Liang , Brian Safina , Birong Zhang

IPC分类号： A61K31/517 , C07D403/04 , A61P29/00 , A61P35/00 , A61P9/00 , A61P25/00 , A61P17/00 , A61P15/02

CPC分类号： C07D239/70

摘要： The present invention provides a compound and pharmaceutically acceptable salts thereof, comprising the Formula I. Also provided are methods of using the compound of this invention as an AKT protein kinase inhibitor and for the treatment of hyperproliferative diseases such as cancer.

摘要翻译： 本发明提供了包含式I的化合物及其药学上可接受的盐。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。