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公开(公告)号：US6015677A
公开(公告)日：2000-01-18
申请号：US139491
申请日：1998-08-25
IPC分类号： C07K14/00 , C07K16/00 , C07K16/40 , C12N1/11 , C12N1/19 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/44 , C12R1/865 , G01N33/15 , G01N33/50 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译： 本发明涉及编码哺乳动物Ca2 + /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。 还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。
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公开(公告)号：US5602019A
公开(公告)日：1997-02-11
申请号：US297510
申请日：1994-08-29
IPC分类号： C07K14/00 , C07K16/00 , C07K16/40 , C12N1/11 , C12N1/19 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/44 , C12R1/865 , G01N33/15 , G01N33/50 , G01N33/53 , C12N1/16 , C12N15/63
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译： 本发明涉及编码哺乳动物Ca2 + /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。 还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。
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公开(公告)号：US07122363B2
公开(公告)日：2006-10-17
申请号：US10697894
申请日：2003-10-30
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译： 本发明涉及编码哺乳动物Ca 2+ /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。 还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。
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公开(公告)号：US06642040B2
公开(公告)日：2003-11-04
申请号：US09883825
申请日：2001-06-18
IPC分类号： C12N916
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译： 本发明涉及编码哺乳动物Ca 2+ /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。 还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。
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5.发明授权Isolated and purified calcium/calmodulin stimulated cyclic nucleotide phosphodiesterases 失效分离和纯化的钙/钙调蛋白刺激的环核苷酸磷酸二酯酶
公开(公告)号：US5776752A
公开(公告)日：1998-07-07
申请号：US479532
申请日：1995-06-07
IPC分类号： C07K14/00 , C07K16/00 , C07K16/40 , C12N1/11 , C12N1/19 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/44 , C12R1/865 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译： 本发明涉及编码哺乳动物Ca2 + /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。 还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。
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公开(公告)号：US07842478B2
公开(公告)日：2010-11-30
申请号：US11501327
申请日：2006-08-09
IPC分类号： C12P21/06
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca2+/calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译： 本发明涉及编码哺乳动物Ca2 + /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。 还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。
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公开(公告)号：US5800987A
公开(公告)日：1998-09-01
申请号：US455525
申请日：1995-05-31
IPC分类号： C07K14/00 , C07K16/00 , C07K16/40 , C12N1/11 , C12N1/19 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/44 , C12R1/865 , G01N33/15 , G01N33/50 , G01N33/53 , C12Q1/68
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
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8.发明授权Antibodies specifically immunoreactive with human brain Ca.sup.2+ /calmodulin cyclic nucleotide phosphodiesterase 失效抗体与人脑Ca2 + /钙调蛋白环核苷酸磷酸二酯酶特异性免疫反应
公开(公告)号：US5789553A
公开(公告)日：1998-08-04
申请号：US455526
申请日：1995-05-31
IPC分类号： C07K14/00 , C07K16/00 , C07K16/40 , C12N1/11 , C12N1/19 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/44 , C12R1/865 , G01N33/15 , G01N33/50 , G01N33/53
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
摘要翻译： 本发明涉及编码哺乳动物Ca2 + /钙调素刺激的磷酸二酯酶（CaM-PDEs）和环状GMP刺激的磷酸二酯酶（cGS-PDEs）的新型纯化和分离的核苷酸序列。 还提供了所述核苷酸序列的相应重组表达产物，与其特异性反应的免疫试剂，以及用于鉴定调节这些表达产物的酶活性的化合物的方法。
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公开(公告)号：US5580771A
公开(公告)日：1996-12-03
申请号：US297494
申请日：1994-08-29
IPC分类号： C07K14/00 , C07K16/00 , C07K16/40 , C12N1/11 , C12N1/19 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/44 , C12R1/865 , G01N33/15 , G01N33/50 , G01N33/53 , C12N1/15 , C12N1/21
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
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公开(公告)号：US5389527A
公开(公告)日：1995-02-14
申请号：US872644
申请日：1992-04-20
IPC分类号： C07K14/00 , C07K16/00 , C07K16/40 , C12N1/11 , C12N1/19 , C12N9/16 , C12N15/09 , C12N15/55 , C12Q1/02 , C12Q1/44 , C12R1/865 , G01N33/15 , G01N33/50 , G01N33/53 , C12N15/63
CPC分类号： G01N33/5091 , C07H21/04 , C07K16/40 , C12N9/16 , C12Q1/025 , C12Q1/44 , G01N33/5008 , G01N33/502 , G01N33/5041 , G01N2333/39
摘要： The present invention relates to novel purified and isolated nucleotide sequences encoding mammalian Ca.sup.2+ /calmodulin stimulated phosphodiesterases (CaM-PDEs) and cyclic-GMP-stimulated phosphodiesterases (cGS-PDEs). Also provided are the corresponding recombinant expression products of said nucleotide sequences, immunological reagents specifically reactive therewith, and procedures for identifying compounds which modulate the enzymatic activity of such expression products.
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