公开(公告)号：US09771579B2

公开(公告)日：2017-09-26

申请号：US13805745

申请日：2011-06-23

申请人： Joseph Collard ,  Olga Khorkova Sherman ,  Belinda De Leon ,  Carlos Coito ,  Jane H. Hsiao

发明人： Joseph Collard ,  Olga Khorkova Sherman ,  Belinda De Leon ,  Carlos Coito ,  Jane H. Hsiao

IPC分类号： C12N15/11 ,  C12N15/113 ,  A61K31/7088 ,  C12Q1/68

CPC分类号： C12N15/113 ,  A61K31/7088 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/113 ,  C12N2310/315 ,  C12Q1/6813 ,  C12N2330/10

摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Sodium channel, voltage-gated, alpha subunit (SCNA), in particular, by targeting natural antisense polynucleotides of Sodium channel, voltage-gated, alpha subunit (SCNA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of SCNA.

公开(公告)号：US20130096183A1

公开(公告)日：2013-04-18

申请号：US13805745

申请日：2011-06-23

申请人： Joseph Collard ,  Olga Khorkova Sherman ,  Belinda De Leon ,  Carlos Coito ,  Jane H. Hsiao

发明人： Joseph Collard ,  Olga Khorkova Sherman ,  Belinda De Leon ,  Carlos Coito ,  Jane H. Hsiao

IPC分类号： C12N15/113 ,  C12Q1/68

CPC分类号： C12N15/113 ,  A61K31/7088 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/113 ,  C12N2310/315 ,  C12Q1/6813 ,  C12N2330/10

摘要： The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Sodium channel, voltage-gated, alpha subunit (SCNA), in particular, by targeting natural antisense polynucleotides of Sodium channel, voltage-gated, alpha subunit (SCNA). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of SCNA.

摘要翻译： 本发明涉及调节钠通道，电压门控α亚基（SCNA）的表达和/或功能的反义寡核苷酸，特别是通过靶向钠通道，电压门控的α亚基（SCNA）的天然反义多核苷酸 ）。 本发明还涉及这些反义寡核苷酸的鉴定及其在治疗与SCNA表达相关的疾病和病症中的用途。

公开(公告)号：US10583128B2

公开(公告)日：2020-03-10

申请号：US14343890

申请日：2012-08-28

申请人： Joseph Collard ,  Olga Khorkova Sherman ,  Jane H. Hsiao

发明人： Joseph Collard ,  Olga Khorkova Sherman ,  Jane H. Hsiao

IPC分类号： A61K31/7048 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/58 ,  A61K31/495 ,  A61K31/5513 ,  A61K31/436 ,  A61K31/5375 ,  A61K31/519 ,  A61K31/4985 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4422 ,  A61K31/365 ,  A61K31/64 ,  A61K31/41 ,  A61K31/135 ,  A61K31/165 ,  A61K31/4245

摘要： Small compounds that modulate the expression of and/or function of sodium channel, voltage-gated, alpha subunit (SCNxA) are presented. Pharmaceutical compositions containing such small molecules and their use in treating diseases and disorders associated with the expression of SCNxA are also presented.