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公开(公告)号：US07279149B2
公开(公告)日：2007-10-09
申请号：US10775562
申请日：2004-02-10
申请人： Joseph F. Poduslo , Geoffrey L. Curran , Thomas M. Wengenack , Daniel J. McCormick , Abdul H. Fauq
发明人： Joseph F. Poduslo , Geoffrey L. Curran , Thomas M. Wengenack , Daniel J. McCormick , Abdul H. Fauq
CPC分类号： A61K49/14 , A61K38/00 , A61K51/08 , A61K51/088 , C07K14/4711
摘要： An amino acid composition with improved blood brain barrier permeability comprising an amino acid polymer, wherein the amino acid comprises at least one asparagyl-4-aminobutane or glutamyl-4-aminobutane residue.
摘要翻译： 具有改善的血脑屏障渗透性的氨基酸组合物，其包含氨基酸聚合物，其中所述氨基酸包含至少一种天冬酰胺酰基-4-氨基丁烷或谷氨酰基-4-氨基丁烷残基。
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公开(公告)号：US07371365B2
公开(公告)日：2008-05-13
申请号：US10351777
申请日：2003-01-27
CPC分类号： A61K49/0002
摘要： Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated β-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.
摘要翻译： 描述了检测活体哺乳动物脑中实质斑块沉积物的方法，其包括对活体哺乳动物施用对细胞外沉积物具有特异结合亲和力的多胺修饰的标记多肽。 还描述了用放射性同位素或造影剂修饰和标记的多胺的分离的β-淀粉样肽。
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公开(公告)号：US20090028789A1
公开(公告)日：2009-01-29
申请号：US12009431
申请日：2008-01-18
CPC分类号： A61K49/0002
摘要： Methods for detecting parenchymal plaque deposits in the brain of a living mammal are described that include administering a polyamine modified, labeled polypeptide having specific binding affinity for the extracellular deposit, to the living mammal. Isolated β-amyloid peptides that are polyamine modified and labeled with a radioisotope or contrast agent also are described.
摘要翻译： 描述了检测活体哺乳动物脑中实质斑块沉积物的方法，其包括对活体哺乳动物施用对细胞外沉积物具有特异结合亲和力的多胺修饰的标记多肽。 还描述了用放射性同位素或造影剂修饰和标记的多胺的分离的β-淀粉样肽。
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公开(公告)号：US20080262339A1
公开(公告)日：2008-10-23
申请号：US11631581
申请日：2005-06-28
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/4088 , A61B5/7285 , G01R33/5673
摘要： Amyloid plaque in the brain of a subject is imaged in an MRI system with or without the use of a contrast agent. Contrast is achieved using a spin-echo pulse sequence that is both respiratory gated and cardiac gated to reduce motion artifacts at the very high image resolution required to see plaque. A preparatory pulse sequence is used to insure longitudinal magnetization remains constant for all the acquired views even if the effective TR changes during the scan due to irregular breathing.
摘要翻译： 受试者脑中的淀粉样斑块在使用或不使用造影剂的MRI系统中成像。 使用呼吸门控和心脏门控的自旋回波脉冲序列来实现对比，以在看到斑块所需的非常高的图像分辨率下减少运动伪影。 准备脉冲序列用于确保纵向磁化对于所有获取的视图保持恒定，即使由于不规则呼吸而在扫描期间有效TR发生变化。
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公开(公告)号：US09320452B2
公开(公告)日：2016-04-26
申请号：US11631581
申请日：2005-06-28
IPC分类号： A61B5/055 , A61B5/00 , G01R33/567
CPC分类号： A61B5/055 , A61B5/4088 , A61B5/7285 , G01R33/5673
摘要： Amyloid plaque in the brain of a subject is imaged in an MRI system with or without the use of a contrast agent. Contrast is achieved using a spin-echo pulse sequence that is both respiratory gated and cardiac gated to reduce motion artifacts at the very high image resolution required to see plaque. A preparatory pulse sequence is used to insure longitudinal magnetization remains constant for all the acquired views even if the effective TR changes during the scan due to irregular breathing.
摘要翻译： 受试者脑中的淀粉样斑块在使用或不使用造影剂的MRI系统中成像。 使用呼吸门控和心脏门控的自旋回波脉冲序列来实现对比，以在看到斑块所需的非常高的图像分辨率下减少运动伪影。 准备脉冲序列用于确保纵向磁化对于所有获取的视图保持恒定，即使由于不规则呼吸而在扫描期间有效TR发生变化。
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