公开(公告)号：US20130030452A1

公开(公告)日：2013-01-31

申请号：US13558483

申请日：2012-07-26

申请人： Joseph ITSKOVITZ-ELDOR ,  Eyal Zussman ,  Lior Lowenstein ,  Naama Zeevi-Levin ,  Liron Eldor

发明人： Joseph ITSKOVITZ-ELDOR ,  Eyal Zussman ,  Lior Lowenstein ,  Naama Zeevi-Levin ,  Liron Eldor

IPC分类号： A61B17/03

CPC分类号： A61L27/34 ,  A61F2/0063 ,  A61L27/50 ,  A61L2420/02 ,  A61L2430/34

摘要： Provided is a device comprising at least two layers, said at least two layers being at least partially overlapping (e.g., superposed) and contacting one another, wherein a first layer of said at least two layers comprises a non-biodegradable mesh, and wherein a second layer of the at least two layers comprises an electrospun element, and wherein the device is devoid of an extracellular matrix generated by mesenchymal progenitor cells, which are characterized by a reduced differentiation potential into an adipogenic lineage by at least about 50% as compared to differentiation potential of mesenchymal stem cells from an adult adipose source under identical assay conditions, and by an increased osteogenic differentiation potential by at least about 20% as compared to the osteogenic differentiation potential of adipose-derived MSCs under identical assays conditions.

摘要翻译： 提供了一种包括至少两层的装置，所述至少两层至少部分重叠（例如重叠）并彼此接触，其中所述至少两层的第一层包括不可生物降解的网，并且其中 所述至少两层的第二层包含电纺丝元件，并且其中所述装置没有由间充质祖细胞产生的细胞外基质，其特征在于与脂肪形成谱系分化潜力降低至少约50％，与 在相同的测定条件下，来自成年脂肪源的间充质干细胞的分化潜能以及在相同测定条件下与脂肪来源的MSC的成骨分化潜能相比，成骨分化潜能增加至少约20％。