公开(公告)号：US20060058705A1

公开(公告)日：2006-03-16

申请号：US11213279

申请日：2005-08-26

申请人： Joseph Leonetti ,  Larry Smith

发明人： Joseph Leonetti ,  Larry Smith

IPC分类号： A61H1/00

CPC分类号： A61B17/2251 ,  A61B8/4272 ,  A61B8/4281 ,  A61B2017/2253

摘要： In vivo biocompatible hydrogels to couple and transmit high intensity ultrasound for hemostasis and ablation during surgery, the hydrogels having 4-40 wt. % of a polymer comprising acrylates and the balance water. A group of hydrogels based on cross-linked methacrylate one of which is polyethyleneglycol methacrylate, can form rigid, low acoustic attenuation coupling members and are in vivo biocompatible. These coupling members consist of hydrogel formulations having mechanical and acoustic properties such that ultrasound transmission standoff members of various dimensions and structural configurations function as efficient ultrasound transmission media and devices within which the ultrasound beam can be transferred to a focal point at the end of the standoff or in close proximity to it.

摘要翻译： 体内生物相容性水凝胶联合和传输高强度超声在手术中止血和消融，水凝胶具有4-40wt。 ％的包含丙烯酸酯和余量的水的聚合物。 一组基于交联甲基丙烯酸酯的水凝胶是甲基丙烯酸聚乙二醇酯，可以形成刚性的低声衰减耦合元件，并且具有体内生物相容性。 这些联接构件由具有机械和声学特性的水凝胶制剂组成，使得各种尺寸和结构配置的超声波传输支架构件起到有效的超声波传输介质和装置的作用，在超声波传输介质和装置中，超声波束可以在其间传递到焦点 或者靠近它。

公开(公告)号：US09394167B2

公开(公告)日：2016-07-19

申请号：US11108078

申请日：2005-04-15

申请人： Karl Maurer ,  John J. Cooper, Jr. ,  H. Sho Fujii ,  Joseph Leonetti

发明人： Karl Maurer ,  John J. Cooper, Jr. ,  H. Sho Fujii ,  Joseph Leonetti

IPC分类号： B01J19/00 ,  C25B11/02 ,  B82Y30/00 ,  C25B3/10

CPC分类号： B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00641 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00713 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01J2219/00736 ,  B82Y30/00 ,  C25B3/10 ,  C25B9/06 ,  C25B11/02

摘要： There is disclosed an electrode array architecture employing continuous and discontinuous circumferential electrodes. There is further disclosed a process for the neutralization of acid generated at anode(s) by base generated at cathode(s) circumferentially located to each other so as to confine a region of pH change. The cathodes can be displayed as concentric rings (continuous) or as counter electrodes in a cross pattern (discontinuous). In this way reagents, such as acid, generated in a center electrode are countered (neutralized) by reagents, such as base, generated at the corners or at the outer ring.