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1.发明授权System and method for manipulating and processing materials using holographic optical trapping 失效使用全息光学捕获来操纵和处理材料的系统和方法公开(公告)号：US07449679B2
公开(公告)日：2008-11-11
申请号：US11079533
申请日：2005-03-15
申请人： Joseph Plewa , Evan Tanner , Daniel Mueth , Lewis Gruber , Kenneth Bradley
发明人： Joseph Plewa , Evan Tanner , Daniel Mueth , Lewis Gruber , Kenneth Bradley
CPC分类号： B82Y20/00 , B82Y10/00 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： A method and apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the at least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
摘要翻译： 一种用于通过用衍射光学元件（DOE）调制激光束而形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的方法和装置。 选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。 根据材料的至少一个所选特征计算DOE的值。 光束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱; 陷阱聚焦到光束焦点或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。
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2.发明申请System and method for manipulating and processing materials using holographic optical trapping 失效使用全息光学捕获来操纵和处理材料的系统和方法公开(公告)号：US20050247866A1
公开(公告)日：2005-11-10
申请号：US11079533
申请日：2005-03-15
申请人： Joseph Plewa , Evan Tanner , Daniel Mueth , Lewis Gruber , Kenneth Bradley
发明人： Joseph Plewa , Evan Tanner , Daniel Mueth , Lewis Gruber , Kenneth Bradley
CPC分类号： B82Y20/00 , B82Y10/00 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： A method an apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the at least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
摘要翻译： 一种用于通过用衍射光学元件（DOE）调制激光束形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的装置的方法。 选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。 根据材料的至少一个所选特征计算DOE的值。 光束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱; 陷阱聚焦到光束焦点或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。
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3.发明申请公开(公告)号：US20050122550A1
公开(公告)日：2005-06-09
申请号：US10974976
申请日：2004-10-28
申请人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
发明人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
CPC分类号： G03H1/22 , G02B5/32 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/2284
摘要： A method an apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the at least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
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4.发明申请System and method for manipulating and processing materials using holographic optical trapping 审中-公开使用全息光学捕获来操纵和处理材料的系统和方法公开(公告)号：US20090002790A1
公开(公告)日：2009-01-01
申请号：US12230430
申请日：2008-08-28
申请人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
发明人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
CPC分类号： B82Y10/00 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： An apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the at least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
摘要翻译： 一种用于通过用衍射光学元件（DOE）调制激光束而形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的装置。 选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。 根据材料的至少一个所选特征计算DOE的值。 光束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱; 陷阱聚焦到光束焦点或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。
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5.发明申请System and method for manipulating and processing materials using holographic optical trapping 审中-公开使用全息光学捕获来操纵和处理材料的系统和方法公开(公告)号：US20090108190A1
公开(公告)日：2009-04-30
申请号：US12230304
申请日：2008-08-27
申请人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
发明人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
IPC分类号： H05H3/04
CPC分类号： B82Y10/00 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： A method for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the at least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
摘要翻译： 一种通过用衍射光学元件（DOE）调制激光束形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的方法。 选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。 根据材料的至少一个所选特征计算DOE的值。 光束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱; 陷阱聚焦到光束焦点或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。
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6.发明授权System and method for manipulating and processing materials using holographic optical trapping 失效使用全息光学捕获来操纵和处理材料的系统和方法公开(公告)号：US07411181B2
公开(公告)日：2008-08-12
申请号：US10974976
申请日：2004-10-28
申请人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
发明人： Joseph Plewa , Evan Tanner , Dan Mueth , Lewis Gruber , Kenneth Bradley
CPC分类号： G03H1/22 , G02B5/32 , G03H1/0005 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/2284
摘要： A method and apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the at least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic. The trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
摘要翻译： 一种用于通过用衍射光学元件（DOE）调制激光束而形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的方法和装置。 选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。 根据材料的至少一个所选特征计算DOE的值。 束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱。 陷阱聚焦到光束对焦或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。
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7.发明授权公开(公告)号：US07482577B2
公开(公告)日：2009-01-27
申请号：US11808677
申请日：2007-06-12
申请人： Lewis Gruber , Kenneth Bradley , Ward Lopes , Robert Lancelot , Joseph Plewa , David Grier
发明人： Lewis Gruber , Kenneth Bradley , Ward Lopes , Robert Lancelot , Joseph Plewa , David Grier
CPC分类号： G01N15/1459 , B01L3/5027 , G01N2015/149 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , H05H3/04
摘要： The present invention employs a beam steering apparatus to isolate valuable cells from other cells, tissues, and contaminants. In one embodiment, the system balances optical trapping against biasing flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation.
摘要翻译： 本发明采用光束转向装置来将有价值的细胞与其它细胞，组织和污染物分离。 在一个实施例中，系统平衡光学捕获与偏置流平衡，以在计算机程序导向的陷阱的灵活控制下平行化细胞分选，其基于它们的组成或标签差异地操纵细胞以引导分离。
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8.发明申请公开(公告)号：US20070235640A1
公开(公告)日：2007-10-11
申请号：US11808677
申请日：2007-06-12
申请人： Lewis Gruber , Kenneth Bradley , Ward Lopes , Robert Lancelot , Joseph Plewa , David Grier
发明人： Lewis Gruber , Kenneth Bradley , Ward Lopes , Robert Lancelot , Joseph Plewa , David Grier
IPC分类号： H05H3/04
CPC分类号： G01N15/1459 , B01L3/5027 , G01N2015/149 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , H05H3/04
摘要： The present invention employs a beam steering apparatus to isolate valuable cells from other cells, tissues, and contaminants. In one embodiment, the system balances optical trapping against biasing flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation.
摘要翻译： 本发明采用光束转向装置来将有价值的细胞与其它细胞，组织和污染物分离。 在一个实施例中，系统平衡光学捕获与偏置流平衡，以在计算机程序导向的陷阱的灵活控制下平行化细胞分选，其基于它们的组成或标签差异地操纵细胞以引导分离。
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9.发明申请Surface Mapping by Optical Manipulation of Particles in Relation to a Functionalized Surface 有权通过光学操作颗粒与功能化表面的表面贴图公开(公告)号：US20110026009A1
公开(公告)日：2011-02-03
申请号：US12440949
申请日：2007-09-14
申请人： Christopher Knutson , Crystal Duke , Gary Stacey , Dan Mueth , Evan Tanner , Osman Akcakir , Haojun Fu , Robert Lancelot , Tania Chakrabarty , Kenneth Bradley
发明人： Christopher Knutson , Crystal Duke , Gary Stacey , Dan Mueth , Evan Tanner , Osman Akcakir , Haojun Fu , Robert Lancelot , Tania Chakrabarty , Kenneth Bradley
CPC分类号： G01N33/48 , G01N33/54373 , G01N33/80
摘要： Methods and apparatus for analyzing surface properties of particles are provided. A method for analyzing the surface properties of the particle includes a associating a first particle with a first capture zone having a specific binding affinity for a first chemical species, applying an optical force to the first particle, sensing a response of the first particle to the optical force, and using the sensed response to determine the presence, absence or quantity of the first chemical species on the first particle surface. This process may be repeated in parallel to test multiple particles. In addition to directly testing the surface properties of the particles, the method can be used in direct, indirect and competitive assays to determine the presence, absence or quantity of free or immobilized analytes. A fluidic cartridge with capture zones having avidities that are tuned for the use of optical forces is provided. A software routine for performing the method is also provided.
摘要翻译： 提供了分析颗粒表面性质的方法和装置。 用于分析颗粒的表面性质的方法包括将第一颗粒与对第一化学物质具有特异性结合亲和力的第一捕获区缔合，向第一颗粒施加光学力，感测第一颗粒对第一颗粒的响应 并且使用感测到的响应来确定第一颗粒表面上的第一化学物质的存在，不存在或数量。 该过程可以并行重复以测试多个颗粒。 除了直接测试颗粒的表面性质之外，该方法可用于直接，间接和竞争性测定，以确定游离或固定化分析物的存在，不存在或数量。 提供了一种具有捕获区域的流体盒，其具有被调整以用于光学力的空间。 还提供了用于执行该方法的软件程序。
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10.发明授权Surface mapping by optical manipulation of particles in relation to a functionalized surface 有权通过相对于功能化表面的颗粒的光学操作的表面映射公开(公告)号：US08169600B2
公开(公告)日：2012-05-01
申请号：US12440949
申请日：2007-09-14
申请人： Christopher Knutson , Crystal Duke , Gary Stacey , Dan Mueth , Evan Tanner , Osman Akcakir , Haojun Fu , Robert Lancelot , Tania Chakrabarty , Kenneth Bradley
发明人： Christopher Knutson , Crystal Duke , Gary Stacey , Dan Mueth , Evan Tanner , Osman Akcakir , Haojun Fu , Robert Lancelot , Tania Chakrabarty , Kenneth Bradley
IPC分类号： G01N33/48
CPC分类号： G01N33/48 , G01N33/54373 , G01N33/80
摘要： Methods and apparatus for analyzing surface properties of particles are provided. A method for analyzing the surface properties of the particle includes a associating a first particle with a first capture zone having a specific binding affinity for a first chemical species, applying an optical force to the first particle, sensing a response of the first particle to the optical force, and using the sensed response to determine the presence, absence or quantity of the first chemical species on the first particle surface. This process may be repeated in parallel to test multiple particles. In addition to directly testing the surface properties of the particles, the method can be used in direct, indirect and competitive assays to determine the presence, absence or quantity of free or immobilized analytes. A fluidic cartridge with capture zones having avidities that are tuned for the use of optical forces is provided. A software routine for performing the method is also provided.
摘要翻译： 提供了分析颗粒表面性质的方法和装置。 用于分析颗粒的表面性质的方法包括将第一颗粒与对第一化学物质具有特异性结合亲和力的第一捕获区缔合，向第一颗粒施加光学力，感测第一颗粒对第一颗粒的响应 并且使用感测到的响应来确定第一颗粒表面上的第一化学物质的存在，不存在或数量。 该过程可以并行重复以测试多个颗粒。 除了直接测试颗粒的表面性质之外，该方法可用于直接，间接和竞争性测定，以确定游离或固定化分析物的存在，不存在或数量。 提供了一种具有捕获区域的流体盒，其具有被调整以用于光学力的空间。 还提供了用于执行该方法的软件程序。
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