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1.发明申请Methods and Compositions for Limiting Viability of a Modified Host Cell Outside of Designated Process Conditions 审中-公开用于限制指定过程条件之外的修饰宿主细胞活力的方法和组合物公开(公告)号：US20150232864A1
公开(公告)日：2015-08-20
申请号：US14642043
申请日：2015-03-09
IPC分类号： C12N15/82
CPC分类号： C12N15/82 , C07K14/435 , C12N13/00 , C12N15/63
摘要： The invention provides methods and compositions for inhibiting proliferation of a modified host cell outside of a designated process condition. Compositions and methods for providing a host cell having reduced viability when exposed to natural conditions external to a controlled environment are disclosed.
摘要翻译： 本发明提供了用于在指定的工艺条件之外抑制修饰的宿主细胞增殖的方法和组合物。 公开了当暴露于受控环境外的自然条件时提供具有降低的活力的宿主细胞的组合物和方法。
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2.发明申请METHODS AND COMPOSITIONS FOR THE AUGMENTATION OF PYRUVATE AND ACETYL-COA FORMATION 审中-公开吡咯烷酮和乙酰辅酶A形成的方法和组合物公开(公告)号：US20150203824A1
公开(公告)日：2015-07-23
申请号：US14417540
申请日：2013-07-26
发明人： Frank A. Skraly
CPC分类号： C12N9/0006 , C12N9/0008 , C12N9/88 , C12P7/065 , C12P7/40 , C12P19/40 , C12Y101/01037 , C12Y101/0104 , C12Y101/01082 , C12Y102/04001 , C12Y102/07005 , C12Y401/01003 , C12Y401/01031 , Y02E50/17
摘要： The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into pyruvate or acetyl-CoA, and in particular the use of such organisms for the commercial production of molecules derived from these precursors, e.g., ethanol.
摘要翻译： 本公开内容确定用于将光自养生物修饰为宿主的方法和组合物，使得生物有效地将二氧化碳和光转化成丙酮酸或乙酰辅酶A，特别是使用这种生物来商业生产衍生自这些前体的分子， 例如乙醇。
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公开(公告)号：US20150176033A1
公开(公告)日：2015-06-25
申请号：US14367866
申请日：2012-12-21
发明人： Michael Connor , Frank A. Skraly
CPC分类号： C12P7/065 , C12N1/12 , C12N9/0065 , C12N15/74 , C12Y111/01006 , C12Y111/01007 , C12Y111/01021 , Y02E50/17
摘要： The present disclosure identifies pathways and mechanisms to confer resistance to reactive oxygen species, e.g., hydrogen peroxide, to photoautotrophic organisms. The use of such organisms in host cell culture systems with high levels of reactive oxygen species, such as host cell culture systems decontaminated with hydrogen peroxide, is contemplated.
摘要翻译： 本公开内容确定赋予光自养生物体对抗氧化活性氧（例如过氧化氢）的抗性的途径和机制。 预期在具有高水平的活性氧的宿主细胞培养系统中使用这些生物体，例如用过氧化氢去污的宿主细胞培养系统。
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4.发明申请Methods and Compositions for the Recombinant Biosynthesis of Terminal Olefins 审中-公开终端烯烃的重组生物合成的方法和组合物公开(公告)号：US20150167023A1
公开(公告)日：2015-06-18
申请号：US14627878
申请日：2015-02-20
CPC分类号： C12P5/026 , C07K2319/00 , C12N9/13 , C12N9/16 , C12P5/007 , C12Y208/02 , C12Y301/02
摘要： The present disclosure identifies methods and compositions for modifying microbial cells, such that the organisms efficiently synthesize terminal olefins, and in particular the use of such organisms for the commercial production of propylene and related molecules.
摘要翻译： 本公开内容确定了用于修饰微生物细胞的方法和组合物，使得生物有效地合成末端烯烃，特别是使用这些生物来商业生产丙烯和相关分子。
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公开(公告)号：US20130210105A1
公开(公告)日：2013-08-15
申请号：US13864884
申请日：2013-04-17
IPC分类号： C12P5/02
CPC分类号： C12P5/026 , C07K2319/00 , C12N9/13 , C12N9/16 , C12P5/007 , C12Y208/02 , C12Y301/02
摘要： The present disclosure identifies methods and compositions for modifying microbial cells, such that the organisms efficiently synthesize terminal olefins, and in particular the use of such organisms for the commercial production of propylene and related molecules.
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