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公开(公告)号:US08017619B2
公开(公告)日:2011-09-13
申请号:US12713811
申请日:2010-02-26
申请人: Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
发明人: Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
IPC分类号: A01N43/54 , A61K31/505 , C07D491/00
CPC分类号: A61K31/496 , C07D239/70 , C07D239/84 , C07D333/22 , C07D333/38 , C07D333/54 , C07D333/70 , C07D471/04 , C07D487/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供了制备化合物的方法,包含该化合物的药学上可接受的组合物,以及使用该化合物和组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US20050148603A1
公开(公告)日:2005-07-07
申请号:US10965695
申请日:2004-10-14
申请人: Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
发明人: Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
IPC分类号: A61K31/496 , C07D239/70 , C07D239/84 , C07D333/22 , C07D333/38 , C07D333/54 , C07D333/70 , C07D471/04 , C07D487/04 , C07D491/14 , C07D495/04 , C07D495/14 , C07D498/04 , C07D513/04 , A61K31/519 , A61K31/517 , C07D491/02 , C07D498/02 , C07D43/02
CPC分类号: A61K31/496 , C07D239/70 , C07D239/84 , C07D333/22 , C07D333/38 , C07D333/54 , C07D333/70 , C07D471/04 , C07D487/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供了制备化合物的方法,包含该化合物的药学上可接受的组合物,以及使用该化合物和组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US20120183577A1
公开(公告)日:2012-07-19
申请号:US13205291
申请日:2011-08-08
申请人: Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
发明人: Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
IPC分类号: A61K39/00 , A61K31/519 , C07D513/04 , A61P7/00 , A61P1/16 , A61P29/00 , A61P19/00 , A61P3/10 , A61P37/00 , A61P37/02 , A61P37/06 , A61K31/5377 , A61P31/12
CPC分类号: A61K31/496 , C07D239/70 , C07D239/84 , C07D333/22 , C07D333/38 , C07D333/54 , C07D333/70 , C07D471/04 , C07D487/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供了制备化合物的方法,包含该化合物的药学上可接受的组合物,以及使用该化合物和组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US07700609B2
公开(公告)日:2010-04-20
申请号:US10965695
申请日:2004-10-14
申请人: Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
发明人: Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
IPC分类号: A61K31/505 , C07D491/00
CPC分类号: A61K31/496 , C07D239/70 , C07D239/84 , C07D333/22 , C07D333/38 , C07D333/54 , C07D333/70 , C07D471/04 , C07D487/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供了制备化合物的方法,包含该化合物的药学上可接受的组合物,以及使用该化合物和组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US08288400B2
公开(公告)日:2012-10-16
申请号:US13205291
申请日:2011-08-08
申请人: Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
发明人: Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
IPC分类号: A01N43/54 , A61K31/505 , C07D239/00 , C07D491/00 , C07D405/00 , C07D417/00
CPC分类号: A61K31/496 , C07D239/70 , C07D239/84 , C07D333/22 , C07D333/38 , C07D333/54 , C07D333/70 , C07D471/04 , C07D487/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供了制备化合物的方法,包含该化合物的药学上可接受的组合物,以及使用该化合物和组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US20100280026A1
公开(公告)日:2010-11-04
申请号:US12713811
申请日:2010-02-26
申请人: Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
发明人: Juan-Miguel Jimenez , Jeremy Green , Huai Gao , Young-Choon Moon , Guy Brenchley , Ronald Knegtel , Francoise Pierard
IPC分类号: A61K31/5377 , A61K31/496 , A61K31/519 , C07D413/14 , C07D495/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P29/00 , A61P9/00 , A61P35/00 , A61P11/06 , A61P19/08 , A61P37/00
CPC分类号: A61K31/496 , C07D239/70 , C07D239/84 , C07D333/22 , C07D333/38 , C07D333/54 , C07D333/70 , C07D471/04 , C07D487/04 , C07D495/04 , C07D495/14 , C07D513/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides processes for preparing the compounds, pharmaceutically acceptable compositions comprising the compounds, and methods of using the compounds and compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供了制备化合物的方法,包含该化合物的药学上可接受的组合物,以及使用该化合物和组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US20060122213A1
公开(公告)日:2006-06-08
申请号:US11170779
申请日:2005-06-29
申请人: Francoise Pierard , Juan-Miguel Jimenez , Ronald Knegtel , Guy Brenchley , Michael Mortimore , Francesca Mazzei
发明人: Francoise Pierard , Juan-Miguel Jimenez , Ronald Knegtel , Guy Brenchley , Michael Mortimore , Francesca Mazzei
IPC分类号: C07D471/02 , A61K31/4745
CPC分类号: C07D471/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing the compounds of the invention.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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公开(公告)号:US20070190634A1
公开(公告)日:2007-08-16
申请号:US11786150
申请日:2007-04-11
申请人: David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人: David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号: C02F3/34
CPC分类号: C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04
摘要: The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US20110086856A1
公开(公告)日:2011-04-14
申请号:US12967675
申请日:2010-12-14
申请人: David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Juliam M.C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人: David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Juliam M.C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号: A61K31/53 , A61K31/517 , A61K31/519 , A61K31/506 , A61K31/496 , C12N9/99 , A61P35/00 , A61P35/02 , A61P25/00 , A61P37/08 , A61P11/06 , A61P25/28 , A61P25/16 , A61P25/18 , A61P9/00 , A61P9/10 , A61P29/00 , A61P19/10 , A61P37/06 , A61P31/12 , A61P19/08 , A61P3/10
CPC分类号: C07D403/12
摘要: The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译: 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病,病症或病症的方法。
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公开(公告)号:US07863282B2
公开(公告)日:2011-01-04
申请号:US11504528
申请日:2006-08-15
申请人: David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
发明人: David Bebbington , Hayley Binch , Jean-Damien Charrier , Simon Everitt , Julian M. C. Golec , David Kay , Ronald Knegtel , Andrew Miller , Francoise Pierard
IPC分类号: A01N43/54 , A61K31/517 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00
CPC分类号: C07D403/12
摘要: A compound of formula Ia: or a pharmaceutically acceptable salt thereof.
摘要翻译: 式Ia化合物或其药学上可接受的盐。
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