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公开(公告)号：US20130090479A1
公开(公告)日：2013-04-11
申请号：US13540651
申请日：2012-07-03
IPC分类号： C07D277/593 , C07D231/14
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
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2.发明授权公开(公告)号：US08865751B2
公开(公告)日：2014-10-21
申请号：US13540651
申请日：2012-07-03
IPC分类号： A61K31/415 , A61K31/426 , C07D231/12 , C07D277/24 , C07D277/593 , C07D233/64 , C07D233/90 , C07D277/56 , C07D231/14
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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3.发明申请THIAZOLES, IMIDAZOLES, AND PYRAZOLES USEFUL AS INHIBITORS OF PROTEIN KINASES 失效作为蛋白激酶抑制剂的THIAZOLES，IMIDAZOLES和PYRAZOLES有用公开(公告)号：US20090306155A1
公开(公告)日：2009-12-10
申请号：US12538396
申请日：2009-08-10
IPC分类号： A61K31/426 , C07D231/14 , C07D277/56 , C12N5/00 , A61P37/00 , A61P29/00 , A61P19/00 , A61P3/00 , A61P25/00 , A61P35/00 , A61K31/415
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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4.发明授权公开(公告)号：US07589214B2
公开(公告)日：2009-09-15
申请号：US11786464
申请日：2007-04-11
IPC分类号： C07D233/64 , A61K31/4164
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds, to methods of using the compounds and to the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含该化合物的药学上可接受的组合物，使用该化合物的方法和组合物治疗各种疾病，病症或病症。 本发明还涉及制备本发明化合物的方法。
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5.发明申请公开(公告)号：US20070298065A1
公开(公告)日：2007-12-27
申请号：US11786464
申请日：2007-04-11
IPC分类号： A61K31/415 , A61K31/4164 , A61K31/426 , A61K9/00 , A61P43/00 , C07D231/02 , C07D233/54 , C07D277/02 , C12N9/99
CPC分类号： C07D277/593 , C07D231/14 , C07D233/64 , C07D233/90 , C07D277/56
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising said compounds and methods of using the compounds and the compositions in the treatment of various disease, conditions, or disorders. The invention also relates to processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还涉及包含所述化合物的药学上可接受的组合物以及在治疗各种疾病，病症或病症中使用该化合物和组合物的方法。 本发明还涉及制备本发明化合物的方法。
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![Process for preparing 5-fluoro-1H-pyrazolo [3,4-B] pyridin-3-amine and derivatives thereof](/abs-image/US/2012/08/14/US08242272B2/abs.jpg.150x150.jpg)
6.发明授权Process for preparing 5-fluoro-1H-pyrazolo [3,4-B] pyridin-3-amine and derivatives thereof 失效制备5-氟-1H-吡唑并[3,4-B]吡啶-3-胺及其衍生物的方法公开(公告)号：US08242272B2
公开(公告)日：2012-08-14
申请号：US12695292
申请日：2010-01-28
申请人： Juan Miguel Jimenez , Philip Collier , Andrew Miller , Jeremy Green , Huai Gao , Sylvain Loïc Jean-Luc Hamon , Albert Cornelis Dros
发明人： Juan Miguel Jimenez , Philip Collier , Andrew Miller , Jeremy Green , Huai Gao , Sylvain Loïc Jean-Luc Hamon , Albert Cornelis Dros
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.
摘要翻译： 本发明涉及以高产率和纯度合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺的方法。 本发明还涉及5-氟-1H-吡唑并[3,4-b]吡啶-3-胺衍生物的合成方法。 这些方法可用于制备生物活性化合物，特别是某些GSK-3抑制剂或其衍生物。
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7.发明申请AMINOPYRIDINES AND AMINOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES 失效作为蛋白激酶抑制剂有用的氨基亚氨酸和氨基酰亚胺公开(公告)号：US20100022502A1
公开(公告)日：2010-01-28
申请号：US12433998
申请日：2009-05-01
IPC分类号： A61K31/397 , C07D401/14 , C12N9/99 , A61P3/10 , A61P25/28 , A61P25/16 , A61P37/00 , A61P25/18 , A61P9/00
CPC分类号： C07D403/12 , C07D403/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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![Pyrrolo [3,2-C] pyridines useful as inhibitors of protein kinases](/abs-image/US/2007/09/13/US20070213327A1/abs.jpg.150x150.jpg)
8.发明申请公开(公告)号：US20070213327A1
公开(公告)日：2007-09-13
申请号：US11705556
申请日：2007-02-12
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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![Process for preparing 5-fluoro-1H-pyrazolo [3,4-B] pyridin-3-amine and derivatives therof](/abs-image/US/2013/12/03/US08598361B2/abs.jpg.150x150.jpg)
9.发明授权Process for preparing 5-fluoro-1H-pyrazolo [3,4-B] pyridin-3-amine and derivatives therof 失效制备5-氟-1H-吡唑并[3,4-B]吡啶-3-胺及其衍生物的方法公开(公告)号：US08598361B2
公开(公告)日：2013-12-03
申请号：US13347926
申请日：2012-01-11
申请人： Juan-Miguel Jimenez , Andrew Miller , Philip Collier , Jeremy Green , Albert Dros , Huai Gao , Sylvain Hamon
发明人： Juan-Miguel Jimenez , Andrew Miller , Philip Collier , Jeremy Green , Albert Dros , Huai Gao , Sylvain Hamon
IPC分类号： C07D215/04
CPC分类号： C07D471/04
摘要： The present invention relates to a process for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine in high yield and purity. The present invention also relates to processes for the synthesis of 5-fluoro-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives. These processes are useful for preparing biologically active compounds, particularly certain GSK-3 inhibitors, or derivatives thereof.
摘要翻译： 本发明涉及以高产率和纯度合成5-氟-1H-吡唑并[3,4-b]吡啶-3-胺的方法。 本发明还涉及5-氟-1H-吡唑并[3,4-b]吡啶-3-胺衍生物的合成方法。 这些方法可用于制备生物活性化合物，特别是某些GSK-3抑制剂或其衍生物。
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公开(公告)号：US08541445B2
公开(公告)日：2013-09-24
申请号：US13289320
申请日：2011-11-04
IPC分类号： A01N43/42 , A61K31/44 , C07D231/56 , C07D487/00 , C07D487/02
CPC分类号： C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 本发明还提供了制备本发明化合物的方法。
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