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公开(公告)号：US20240013946A1
公开(公告)日：2024-01-11
申请号：US18471959
申请日：2023-09-21
CPC分类号： A61M5/14 , G21G1/0005 , A61M2205/502 , A61M2205/3334 , A61M2205/581 , A61M2205/583
摘要： A radioisotope elution system is provided. The radioisotope elution system may comprise a controller that is configured to calculate the available amount of daughter radioisotope at any time during establishment of the equilibrium for decay of the parent radioisotope into its daughter radioisotope. The radioisotope elution system may comprise a controller that is configured to schedule various patient infusions planned for the next following days and weeks in accordance with the available amount of daughter radioisotope on each day. The elution system may also comprise a controller that is connected to the imaging software of a radioisotope imaging device, where the radioisotope imaging device is arranged for imaging the patient or a region of the patient; and the controller is configured to start an image acquisition at a predetermined time.
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公开(公告)号：US20210313084A1
公开(公告)日：2021-10-07
申请号：US17269588
申请日：2019-08-22
发明人： Robert William RIDDOCH , Etienne LEFORT , Paul DONNELLY , Riccardo SANTOPIETRO , Thomas Allen MOORE
摘要： Disclosed herein are rubidium elution systems comprising a primary assembly including a 82Sr/82Rb generator, an activity detector, a waste container, a pump system, a sensor, a tubing circuit, at least one valve, and a computer; and a dose calibrator outside the primary assembly. The system may have an interface for configuring the dose calibrator, and a locking means for preventing access to the interface and reconfigurations of its parameters. Moreover, the dose calibrator may be in electronic communication with the computer of the system. Furthermore, the electronic communication can be embodied with an electronic cable having a breakaway connector. Also, the dose calibrator may be positioned on a mobile platform.
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公开(公告)号：US20210166830A1
公开(公告)日：2021-06-03
申请号：US17173874
申请日：2021-02-11
发明人： Etienne LEFORT , Vincenzo TEOLI , Robert A. DEKEMP , Ran KLEIN
摘要： Embodiments of the present invention provide for assessing the state of an 82Rb elution system. In certain embodiments, a system begins an assessment that comprises an elution, and a metric may be measured. This metric may be a concentration of 82Rb, 82Sr, or 85Sr in a fluid that is eluted from the generator, the volume of the fluid that is eluted from the generator, or the pressure of the fluid flowing through at least one portion of the system. If the assessment is completed, an output may be generated on a user interface that recommends a course of action, or no course of action, based on a result of the assessment. Should the assessment not complete successfully because it is interrupted, a 82Sr/82Rb generator of the system may be halted so as to prevent a user from performing an end-run around these quality control mechanisms of the 82Rb elution system.
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公开(公告)号：US20240181097A1
公开(公告)日：2024-06-06
申请号：US18439175
申请日：2024-02-12
发明人： Riccardo SANTOPIETRO , Robert William RIDDOCH , Paul DONNELLY , Etienne LEFORT , Cristian-Leonardo JUVERDIANU
CPC分类号： A61K51/1217 , G21F5/015 , G21G4/08
摘要： A radioisotope elution system is provided that has a component in a cabinet with a door equipped with an authentication system to open. The system may also have a user interface equipped with an authentication system. The radioisotope elution system has a dose calibrator equipped with a lifting mechanism for lifting and/or lowering the vial to be tested in the dose calibrator. The lifting mechanism may be controlled for preventing the vial from being lifted during a quality control test on a sample of eluate in the vial. This feature prevents a user from tampering and/or interfering with the vial while a quality control testing is in progress. There also is provided a radioisotope elution system with a scanning system for entering information about the radioisotope generator and/or the patient in the system. Systems ensuring that the eluant reservoir contains a saline solution are proposed.
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公开(公告)号：US20240055148A1
公开(公告)日：2024-02-15
申请号：US18302663
申请日：2023-04-18
发明人： Etienne LEFORT , Vicenzo TEOLI , Robert A. DEKEMP , Ran KLEIN
CPC分类号： G21G1/0005 , F04B49/065 , G05B15/02
摘要： Embodiments of the present invention provide for assessing the state of an 82Rb elution system. In certain embodiments, a system begins an assessment that comprises an elution, and a metric may be measured. This metric may be a concentration of 82Rb, 82Sr, or 85Sr in a fluid that is eluted from the generator, the volume of the fluid that is eluted from the generator, or the pressure of the fluid flowing through at least one portion of the system. If the assessment is completed, an output may be generated on a user interface that recommends a course of action, or no course of action, based on a result of the assessment. Should the assessment not complete successfully because it is interrupted, a 82Sr/82Rb generator of the system may be halted so as to prevent a user from performing an end-run around these quality control mechanisms of the 82Rb elution system.
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公开(公告)号：US20210308364A1
公开(公告)日：2021-10-07
申请号：US17269578
申请日：2019-08-22
发明人： Robert William RIDDOCH , Etienne LEFORT , Paul DONNELLY , Riccardo SANTOPIETRO , Thomas Allen MOORE
摘要： Disclosed are new configurations of a rubidium elution system that offer several advantages. The rubidium elution systems of the present disclosure comprise an assembly including a 82Sr/82Rb generator, an activity detector, a waste container, a pump, a sensor, a tubing circuit, at least one valve, where the waste container is located in the lower section of the assembly. More particularly, the top surface of the waste container compartment is either below the top surface of the generator compartment, or the waste container is at the same elevation than the generator or below the pump.
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公开(公告)号：US20200312474A1
公开(公告)日：2020-10-01
申请号：US16832436
申请日：2020-03-27
摘要： A radioisotope elution system is provided. The radioisotope elution system may comprise a controller that is configured to calculate the available amount of daughter radioisotope at any time during establishment of the equilibrium for decay of the parent radioisotope into its daughter radioisotope. The radioisotope elution system may comprise a controller that is configured to schedule various patient infusions planned for the next following days and weeks in accordance with the available amount of daughter radioisotope on each day. The elution system may also comprise a controller that is connected to the imaging software of a radioisotope imaging device, where the radioisotope imaging device is arranged for imaging the patient or a region of the patient; and the controller is configured to start an image acquisition at a predetermined time.
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公开(公告)号：US20220347377A1
公开(公告)日：2022-11-03
申请号：US17849372
申请日：2022-06-24
发明人： Etienne LEFORT , Vincenzo TEOLI , Robert A. DEKEMP , Ran KLEIN
摘要： Provided are 82Sr/82Rb elution systems that accept patient weight as a input function in order to determine an optimal quantity of radioactive rubidium-82 for delivery to a patient pursuant to an imaging scan. Also disclosed are systems that deliver a saline flush to remove residual 82Rb from the system downstream of the generator, and preferably deliver the removed residual 82Rb to the patient. Other disclosed systems measure the total volume of saline that flows through a 82Sr/82Rb generator, a total volume of saline that flows through the generator and through a bypass line, or a total volume of saline received by a waste reservoir, in order to monitor system components so that optimal system functioning is assured.
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公开(公告)号：US20200306393A1
公开(公告)日：2020-10-01
申请号：US16832412
申请日：2020-03-27
发明人： Riccardo SANTOPIETRO , Robert William RIDDOCH , Paul DONNELLY , Etienne LEFORT , Cristian-Leonardo JUVERDIANU
摘要： A radioisotope elution system is provided, that has at least a component comprised in a cabinet and accessible via a door equipped with an authentication system to ensure safety. The system may also have a user interface equipped with an authentication system. It is also provided a radioisotope elution system that has a dose calibrator equipped with a lifting mechanism for lifting and/or lowering the vial to be tested in the dose calibrator. Advantageously, the lifting mechanism may be controlled for preventing the vial from being lifted during a quality control test on a sample of eluate in the vial. This feature prevents a user from tampering and/or interfering with the vial while a quality control testing is in progress. In another feature, there is provided a radioisotope elution system with a scanning system for entering information about the radioisotope generator and/or the patient in the system. Systems ensuring that the eluant reservoir contains a saline solution are proposed.
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