-
公开(公告)号：US20240299641A1
公开(公告)日：2024-09-12
申请号：US18662366
申请日：2024-05-13
发明人： Robert William Riddoch , Etienne Lefort , Paul Donnelly , Riccardo Santopietro , Thomas Allen Moore
CPC分类号： A61M5/007 , A61M5/14212 , A61M5/1452 , F04B17/03 , F04B43/12 , F04B49/065 , G21G1/0005 , A61B6/037 , G21G2001/0031
摘要： Disclosed are new configurations of a rubidium elution system that offer several advantages. The rubidium elution systems of the present disclosure comprise an assembly including a 82Sr/82Rb generator, an activity detector, a waste container, a pump, a sensor, a tubing circuit and at least one valve. The waste container is located in the lower section of the assembly. More particularly, the top surface of the waste container compartment is either below the top surface of the generator compartment, or the waste container is at the same elevation than the generator or below the pump.
-
公开(公告)号：US20240193767A1
公开(公告)日：2024-06-13
申请号：US18412857
申请日：2024-01-15
CPC分类号： G06T7/0012 , G06T7/11 , G06T2207/20084 , G06T2207/30101
摘要： The present invention discloses methods for automatically computing an arterial input function from one or more regions of interest, the method comprising: a. obtaining a plurality of dynamic image data sets comprising volumetric image data from the regions of interest over multiple scanning intervals; b. utilizing an artificial neural network to segment the plurality of dynamic image data sets displaying one or more arterial input function(s) (AIF) in the region(s) of interest; c. automatically estimating, using artificial intelligence, an arterial input function based on plurality of dynamic image data sets combined with one or more time activity curves (TAC) in the region(s) of interest in target organ(s); and d. computing a pre-trained predictive pharmacokinetic AI model arterial input function using time activity curve input associated with region(s) of interest of target organ(s).
-
3.发明申请公开(公告)号：US20210268187A1
公开(公告)日：2021-09-02
申请号：US16803098
申请日：2020-02-27
摘要： Syringe shield (2) includes a barrel housing (4), which includes: a barrel housing (6) with a radiation-shielding material, a first open end (8), and a second open end (10); and a removable cover (12) which is slidably connectable to the barrel housing (6). The removable cover (12) includes an end cap (14) which covers the second open end (10) when the removable cover (12) is slidably connected to the barrel housing (6). The barrel housing (4) also includes a plunger housing (16) with a radiation-shielding material. A first end (18) of the plunger housing (16) is open and is connectable to the first open end (8) of the barrel housing (4), and a second end (20) of the plunger housing (16) includes a top cap (22).
-
公开(公告)号：US20240316226A1
公开(公告)日：2024-09-26
申请号：US18614094
申请日：2024-03-22
发明人： Indranil Nandi , Vijayaraj Kuniyil Kulangara , Miriam Ruiz Pena , Aida Mary Abreu Diaz , Sara Elkashef
CPC分类号： A61K51/088 , A61K51/1244
摘要： The present invention provides a conjugate compound comprising a nanoparticulated enhanced permeability and retention (EPR) agent, which is an albumin, conjugated with one or more chelating agents, one or more target specific ligands and one or more detectable agents and optionally comprising one or more heterobifunctional crosslinkers and one or more pharmaceutically acceptable therapeutic agents. Further, the present invention provides a radiopharmaceutical composition and a kit comprising the said conjugate and also provides application of the same in diagnosis and therapy of various disease like cancer.
-
公开(公告)号：US11904028B2
公开(公告)日：2024-02-20
申请号：US16832412
申请日：2020-03-27
发明人： Riccardo Santopietro , Robert William Riddoch , Paul Donnelly , Etienne Lefort , Cristian-Leonardo Juverdianu
CPC分类号： A61K51/1217 , G21F5/015 , G21G4/08
摘要： A radioisotope elution system is provided, that has at least a component comprised in a cabinet and accessible via a door equipped with an authentication system to ensure safety. The system may also have a user interface equipped with an authentication system. It is also provided a radioisotope elution system that has a dose calibrator equipped with a lifting mechanism for lifting and/or lowering the vial to be tested in the dose calibrator. Advantageously, the lifting mechanism may be controlled for preventing the vial from being lifted during a quality control test on a sample of eluate in the vial. This feature prevents a user from tampering and/or interfering with the vial while a quality control testing is in progress. In another feature, there is provided a radioisotope elution system with a scanning system for entering information about the radioisotope generator and/or the patient in the system. Systems ensuring that the eluant reservoir contains a saline solution are proposed.
-
公开(公告)号：US20240013946A1
公开(公告)日：2024-01-11
申请号：US18471959
申请日：2023-09-21
CPC分类号： A61M5/14 , G21G1/0005 , A61M2205/502 , A61M2205/3334 , A61M2205/581 , A61M2205/583
摘要： A radioisotope elution system is provided. The radioisotope elution system may comprise a controller that is configured to calculate the available amount of daughter radioisotope at any time during establishment of the equilibrium for decay of the parent radioisotope into its daughter radioisotope. The radioisotope elution system may comprise a controller that is configured to schedule various patient infusions planned for the next following days and weeks in accordance with the available amount of daughter radioisotope on each day. The elution system may also comprise a controller that is connected to the imaging software of a radioisotope imaging device, where the radioisotope imaging device is arranged for imaging the patient or a region of the patient; and the controller is configured to start an image acquisition at a predetermined time.
-
公开(公告)号：USD934419S1
公开(公告)日：2021-10-26
申请号：US29728818
申请日：2020-03-20
-
公开(公告)号：US20210313084A1
公开(公告)日：2021-10-07
申请号：US17269588
申请日：2019-08-22
发明人： Robert William RIDDOCH , Etienne LEFORT , Paul DONNELLY , Riccardo SANTOPIETRO , Thomas Allen MOORE
摘要： Disclosed herein are rubidium elution systems comprising a primary assembly including a 82Sr/82Rb generator, an activity detector, a waste container, a pump system, a sensor, a tubing circuit, at least one valve, and a computer; and a dose calibrator outside the primary assembly. The system may have an interface for configuring the dose calibrator, and a locking means for preventing access to the interface and reconfigurations of its parameters. Moreover, the dose calibrator may be in electronic communication with the computer of the system. Furthermore, the electronic communication can be embodied with an electronic cable having a breakaway connector. Also, the dose calibrator may be positioned on a mobile platform.
-
公开(公告)号：US20210166830A1
公开(公告)日：2021-06-03
申请号：US17173874
申请日：2021-02-11
发明人： Etienne LEFORT , Vincenzo TEOLI , Robert A. DEKEMP , Ran KLEIN
摘要： Embodiments of the present invention provide for assessing the state of an 82Rb elution system. In certain embodiments, a system begins an assessment that comprises an elution, and a metric may be measured. This metric may be a concentration of 82Rb, 82Sr, or 85Sr in a fluid that is eluted from the generator, the volume of the fluid that is eluted from the generator, or the pressure of the fluid flowing through at least one portion of the system. If the assessment is completed, an output may be generated on a user interface that recommends a course of action, or no course of action, based on a result of the assessment. Should the assessment not complete successfully because it is interrupted, a 82Sr/82Rb generator of the system may be halted so as to prevent a user from performing an end-run around these quality control mechanisms of the 82Rb elution system.
-
公开(公告)号：US12102789B1
公开(公告)日：2024-10-01
申请号：US18618798
申请日：2024-03-27
发明人： James A. Kaufman , Dominic Siewko , Indranil Nandi
CPC分类号： A61M5/142 , A61M5/16831 , A61M5/1785 , G16H10/60 , G16H40/63 , A61M2005/14208 , A61M2005/16863 , A61M2202/0007 , A61M2202/049 , A61M2205/10 , A61M2205/18 , A61M2205/3327 , A61M2205/3331 , A61M2205/3379 , A61M2205/502 , A61M2205/584 , A61M2205/6009
摘要： The invention is a theranostic delivery system or radiopharmaceutical drugs delivery system with movable workstation having handles. The workstation of theranostic delivery system or radiopharmaceutical drugs delivery system also has an on-board shielded disposal system for waste collection, which is operated by foot actuated system for locked and unlocked modes during the device journey. The theranostic delivery system or radiopharmaceutical drugs delivery system comprises a status light system that illuminates the working area to enable distance monitoring. Further, the delivery system includes a disposable secondary containment system that protects the core workstation from contamination, a configurable dose transporter and a disposable sealed fluid cartridge to withdraw custom volume from the vial or syringe. The delivery system includes a theranostic informatics management system, which contains a computer screen as a graphical user interface with a retractable rotating arm to receive the various patient infusion parameters.
-
-
-
-
-
-
-
-
-
搜索结果
44 条记录 (耗时 0.015 秒)
