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    Method for screening neurogenic agents
    4.
    发明授权
    Method for screening neurogenic agents 有权
    筛查神经源性药物的方法

    公开(公告)号：US08293488B2

    公开(公告)日：2012-10-23

    申请号：US11852922

    申请日：2007-09-10

    申请人： Judith Kelleher-Andersson ,  Karl K. Johe

    发明人： Judith Kelleher-Andersson ,  Karl K. Johe

    IPC分类号： G01N33/567

    CPC分类号： G01N33/5058

    摘要： A method for discovering neurogenic drugs is revealed. The method allows for systematic screening of test agents such as libraries of compounds. The method consists of exposing test agents to cultures of differentiating neural progenitor cells and measuring their effects on increasing the overall cell number and/or the number of neurons.

    摘要翻译： 揭示了一种发现神经源性药物的方法。 该方法允许对诸如化合物文库的试剂进行系统筛选。 该方法包括将测试试剂暴露于分化神经祖细胞的培养物，并测量它们对增加总细胞数量和/或神经元数量的影响。

    METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING DOWN SYNDROME
    7.
    发明申请
    METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING DOWN SYNDROME 审中-公开
    用于治疗下肢综合征的方法和药物组合物

    公开(公告)号：US20120277218A1

    公开(公告)日：2012-11-01

    申请号：US13497341

    申请日：2010-09-22

    申请人： Judith Kelleher-Andersson

    发明人： Judith Kelleher-Andersson

    IPC分类号： A61K31/551 ,  A61P25/00

    CPC分类号： A61K31/551 ,  A61K31/275 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/519 ,  A61K31/55

    摘要： The compounds and pharmaceutical compositions of the present invention are believed to significantly inhibit Dyrk 1a activity which suggests that the agents could provide therapeutic benefit for Down syndrome, since Dyrk 1a overproduction in Down syndrome appears to account for the developmental cognitive impairment and reduction in neurogenesis. The compounds and pharmaceutical compositions, administered during early post-natal development, may increase neurogenesis and thereby reduce cognitive impairment which may ultimately allow individuals with Down syndrome to live a more independent life.

    摘要翻译： 据信本发明的化合物和药物组合物显着抑制Dyrk 1a活性，这表明该试剂可以为唐氏综合征提供治疗益处，因为唐氏综合征中的Dyrk1α过度产生似乎解释了发育型认知障碍和神经发生的减少。 在早期产后发育期间施用的化合物和药物组合物可能增加神经发生，从而减少认知功能损害，这可能最终允许患有唐氏综合征的个体生活更独立的生活。

    METHODS AND COMPOSITIONS FOR STIMULATING NEUROGENESIS AND INHIBITING NEURONAL DEGENERATION USING ISOTHIAZOLOPYRIMIDINONES
    8.
    发明申请
    METHODS AND COMPOSITIONS FOR STIMULATING NEUROGENESIS AND INHIBITING NEURONAL DEGENERATION USING ISOTHIAZOLOPYRIMIDINONES 有权
    刺激神经发生和抑制神经元变性的方法和组合使用异亮氨酸嘧啶酮

    公开(公告)号：US20100298318A1

    公开(公告)日：2010-11-25

    申请号：US12664995

    申请日：2008-06-20

    申请人： Judith Kelleher-Andersson

    发明人： Judith Kelleher-Andersson

    IPC分类号： A61K31/5377 ,  A61K31/519 ,  C07D513/04 ,  A61P25/00 ,  A61P25/28

    CPC分类号： A61K31/519 ,  A61K31/5377 ,  C07D513/04

    摘要： The present invention provides methods and compositions comprising compounds useful for stimulating neurogenesis. The methods and compositions comprising compounds are also useful for inhibiting neuronal degeneration. Thus, the present invention can be used in the treatment of diseases and conditions characterized by neuronal loss and reduced neurogenesis including Alzheimer's disease, stroke, traumatic brain injury, traumatic nerve injury, and depression. This invention is useful for resear products including single agents or mixtures of agents to promote, proliferate, differentiate, or maintain neurons from stem or progenitor cells.

    摘要翻译： 本发明提供包含可用于刺激神经发生的化合物的方法和组合物。 包含化合物的方法和组合物也可用于抑制神经元变性。 因此，本发明可用于治疗以神经元丧失和神经发生减少为特征的疾病和病症，包括阿尔茨海默病，中风，创伤性脑损伤，创伤神经损伤和抑郁症。 本发明对包括单一试剂或试剂混合物在内的研究产品可用于促进，增殖，分化或维持神经元与干细胞或祖细胞。

    Isolation and Differentiation of Adult Hippocampal Arctic Squirrel Neural Stem Cells
    10.
    发明申请
    Isolation and Differentiation of Adult Hippocampal Arctic Squirrel Neural Stem Cells 审中-公开
    成人海马北极松鼠神经干细胞的分离和分化

    公开(公告)号：US20090305403A1

    公开(公告)日：2009-12-10

    申请号：US12439218

    申请日：2007-08-31

    申请人： Judith Kelleher-Andersson

    发明人： Judith Kelleher-Andersson

    IPC分类号： C12N5/10 ,  C12N5/06 ,  C07K16/18

    CPC分类号： C12N5/0623 ,  A61K35/12 ,  C07K16/28 ,  C12N2503/02 ,  C12N2510/00

    摘要： Neuronal stem cell lines derived from the Arctic Ground Squirrel, methods related to culturing and maintaining a neuronal stem cell line derived from the Arctic Ground Squirrel and a culture media required to maintain and differentiate a neuronal stem cell line derived from the Arctic Ground Squirrel is disclosed. Antibodies specific for antigens expressed on a neuronal stem cell line derived from the Arctic Ground Squirrel, and products and methods related to the use of neuronal stem cell lines derived from the Arctic Ground Squirrel are also included.

    摘要翻译： 公开了来自北极地松鼠的神经元干细胞系，其中涉及培养和维持源自北极地松鼠的神经元干细胞系的方法和维持和分化源自北极地松鼠的神经元干细胞系所需的培养基 。 对来自北极地松鼠的神经元干细胞系上表达的抗原的特异性抗体，以及与使用来自北极松鼠的神经元干细胞系相关的产品和方法也包括在内。