公开(公告)号：US20120252057A1

公开(公告)日：2012-10-04

申请号：US13320610

申请日：2010-05-12

申请人： Juergen Schrelber ,  Joerg Opitz ,  Carola Gerich ,  Jens Fehre ,  Georg Salomon ,  Ralf Nanke

发明人： Juergen Schrelber ,  Joerg Opitz ,  Carola Gerich ,  Jens Fehre ,  Georg Salomon ,  Ralf Nanke

IPC分类号： G01N21/64 ,  C12M1/34

CPC分类号： G01N21/6486 ,  A61B5/0059 ,  G01N21/6408

摘要： The invention relates to a method and to an apparatus for recognizing tumorous living cell tissue. It furthermore relates to a method and to an apparatus for recognizing tumorous cell tissue at collected living cell tissue samples. In the method, electromagnetic radiation is emitted with local definition onto cell tissue by a radiation source and, after deactivation of the radiation source, the decay behavior of the inherent fluorescence intensity of the cell tissue excited by the electromagnetic radiation is detected at the cell tissue in a time resolved and spectrally resolved manner at known sampling rate(s) for at least one wavelength using a detector. The difference autocorrelation function C(t) of the intensity decay behavior is determined using the determined measured intensity values, the fractal dimension DF for the respective irradiated cell tissue is calculated from this and the value of the fractal dimension DF is used for a classification with respect to a presence of a tumor in the respective irradiated cell tissue.

摘要翻译： 本发明涉及用于识别肿瘤活细胞组织的方法和装置。 此外，本发明还涉及用于在收集的活细胞组织样品处识别肿瘤细胞组织的方法和装置。 在该方法中，电磁辐射通过辐射源以局部定义发射到细胞组织上，并且在放射源失活之后，在细胞组织处检测由电磁辐射激发的细胞组织的固有荧光强度的衰变行为 以使用检测器的至少一个波长的已知采样速率以时间分辨和频谱分辨的方式。 使用确定的测量强度值确定强度衰减行为的差分自相关函数C（t），并从其计算相应的照射细胞组织的分形维数DF，并且使用分形维数DF的值进行分类， 相对于各自照射的细胞组织中肿瘤的存在。