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    Aβ binding molecules
    5.
    发明授权
    Aβ binding molecules 有权
    Abeta结合分子

    公开(公告)号：US08623365B2

    公开(公告)日：2014-01-07

    申请号：US13332753

    申请日：2011-12-21

    申请人： Julian Davies ,  Ying Tang ,  Jeffry Dean Watkins

    发明人： Julian Davies ,  Ying Tang ,  Jeffry Dean Watkins

    IPC分类号： A61K39/395

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarity determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prevention of conditions and diseases associated with Aβ, including Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like.

    摘要翻译： 本发明包括使用衍生自鼠抗体266的互补决定区的鼠抗体266的人源化变体的分离的抗体或其片段。变体抗体可用于治疗或预防与Aβ相关的病症和疾病，包括阿尔茨海默氏病 唐氏综合征，脑淀粉样血管病，轻度认知障碍等。

    Aβ binding molecules
    6.
    发明授权
    Aβ binding molecules 有权
    A＆bgr 结合分子

    公开(公告)号：US08105597B2

    公开(公告)日：2012-01-31

    申请号：US12504818

    申请日：2009-07-17

    申请人： Julian Davies ,  Ying Tang ,  Jeffry Dean Watkins

    发明人： Julian Davies ,  Ying Tang ,  Jeffry Dean Watkins

    IPC分类号： A61K39/395 ,  C07K16/18

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarily determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prevention of conditions and diseases associated with Aβ, including Alzheimer's disease. Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like.

    摘要翻译： 本发明包括分离的抗体或其片段，其是使用来自鼠抗体266的互补决定区的鼠抗体266的人源化变体。变体抗体可用于治疗或预防与A＆bgr相关的病症和疾病，包括阿尔茨海默病 疾病。 唐氏综合征，脑淀粉样血管病，轻度认知障碍等。

    ß binding molecules
    7.
    发明申请
    ß binding molecules 有权
    β结合分子

    公开(公告)号：US20060110388A1

    公开(公告)日：2006-05-25

    申请号：US10544050

    申请日：2004-02-06

    申请人： Julian Davies ,  Ying Tang ,  Jeffry Watkins

    发明人： Julian Davies ,  Ying Tang ,  Jeffry Watkins

    IPC分类号： A61K39/395 ,  C07K16/18

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarity determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prevention of conditions and diseases associated with Aβ, including Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like.

    摘要翻译： 本发明包括使用衍生自鼠抗体266的互补决定区的鼠抗体266的人源化变体的分离的抗体或其片段。变体抗体可用于治疗或预防与Aβ相关的病症和疾病，包括阿尔茨海默氏病 唐氏综合征，脑淀粉样血管病，轻度认知障碍等。

    RECOMBINANT IL-9 ANTIBODIES AND USES THEREOF
    8.
    发明申请
    RECOMBINANT IL-9 ANTIBODIES AND USES THEREOF 失效
    重组IL-9抗体及其用途

    公开(公告)号：US20120109097A1

    公开(公告)日：2012-05-03

    申请号：US13007211

    申请日：2011-01-14

    申请人： Jennifer Lynne Reed ,  Herren Wu ,  Ying Tang ,  Julian Davies ,  Jeffry D. Watkins

    发明人： Jennifer Lynne Reed ,  Herren Wu ,  Ying Tang ,  Julian Davies ,  Jeffry D. Watkins

    IPC分类号： A61B19/00 ,  C07K16/24

    CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869

    摘要： The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.

    摘要翻译： 本发明提供免疫特异性结合IL-9多肽的新型抗体和包含所述抗体的组合物。 本发明还提供了预防，治疗，治疗和/或改善与IL 9或IL-9受体或其亚基的异常表达和/或活性相关的疾病和病症的方法和组合物，自身免疫性疾病，炎性疾病，增殖性疾病， 以及感染，其包括施用一种或多种免疫特异性结合IL-9多肽的抗体。 本发明还包括用于诊断，监测和预测这些疾病的方法和组合物。 本发明还涉及包含免疫特异性结合IL-9多肽的抗体的制品和试剂盒。

    ABETA BINDING MOLECULES
    9.
    发明申请
    ABETA BINDING MOLECULES 有权
    ABETA结合分子

    公开(公告)号：US20090297505A1

    公开(公告)日：2009-12-03

    申请号：US12504818

    申请日：2009-07-17

    申请人： Julian Davies ,  Ying Tang ,  Jeffry Dean Watkins

    发明人： Julian Davies ,  Ying Tang ,  Jeffry Dean Watkins

    IPC分类号： A61K39/395 ,  C07K16/18 ,  A61P25/28

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92

    摘要： The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarily determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prevention of conditions and diseases associated with Aβ, including Alzheimer's disease. Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like.

    摘要翻译： 本发明包括分离的抗体或其片段，其是使用来自鼠抗体266的互补决定区的鼠抗体266的人源化变体。变体抗体可用于治疗或预防与Aβ相关的病症和疾病，包括阿尔茨海默氏病 。 唐氏综合征，脑淀粉样血管病，轻度认知障碍等。

    RECOMBINANT IL-9 ANTIBODIES AND USES THEREOF
    10.
    发明申请
    RECOMBINANT IL-9 ANTIBODIES AND USES THEREOF 审中-公开
    重组IL-9抗体及其用途

    公开(公告)号：US20090047277A1

    公开(公告)日：2009-02-19

    申请号：US11769326

    申请日：2007-06-27

    申请人： Jennifer Lynne REED ,  Herren Wu ,  Ying Tang ,  Julian Davies ,  Jeffry D. Watkins

    发明人： Jennifer Lynne REED ,  Herren Wu ,  Ying Tang ,  Julian Davies ,  Jeffry D. Watkins

    IPC分类号： A61K39/395 ,  C07K16/18 ,  G01N33/53 ,  A61P43/00

    CPC分类号： C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/6869

    摘要： The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.

    摘要翻译： 本发明提供免疫特异性结合IL-9多肽的新型抗体和包含所述抗体的组合物。 本发明还提供了预防，治疗，治疗和/或改善与IL 9或IL-9受体或其亚基的异常表达和/或活性相关的疾病和病症的方法和组合物，自身免疫性疾病，炎性疾病，增殖性疾病， 以及感染，其包括施用一种或多种免疫特异性结合IL-9多肽的抗体。 本发明还包括用于诊断，监测和预测这些疾病的方法和组合物。 本发明还涉及包含免疫特异性结合IL-9多肽的抗体的制品和试剂盒。