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公开(公告)号：US20080089892A1
公开(公告)日：2008-04-17
申请号：US10584692
申请日：2005-01-10
IPC分类号： A61K39/395 , A61P43/00 , C07K16/00
CPC分类号： C07K16/2896 , C07K16/00 , C07K2317/21 , C07K2317/52 , C07K2317/565 , C07K2317/732 , C07K2317/734
摘要： The present invention provides polypeptide Fc region variants and oligonucleotides encoding Fc region variants. Specifically, the present invention provides compositions comprising novel Fc region variants, methods for identifying useful Fc region variants, and methods for employing Fc region variants for treating disease.
摘要翻译： 本发明提供多肽Fc区变体和编码Fc区变体的寡核苷酸。 具体地，本发明提供包含新型Fc区变体的组合物，用于鉴定有用Fc区变体的方法，以及使用Fc区变体用于治疗疾病的方法。
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公开(公告)号：US20090202986A1
公开(公告)日：2009-08-13
申请号：US11577061
申请日：2004-10-28
申请人： William D. Huse , Jeffry Dean Watkins , Alain Philippe Vasserot , David Matthew Marquis , Eric Michael Smith
发明人： William D. Huse , Jeffry Dean Watkins , Alain Philippe Vasserot , David Matthew Marquis , Eric Michael Smith
IPC分类号： C12Q1/68
CPC分类号： C07K16/2878 , C07K16/36 , C07K16/464 , C07K16/465 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/92
摘要： The present invention provides optimized heteromeric variable region binding fragments and antibodies comprising optimized heteromeric variable region binding fragments. Preferably, the optimized heteromeric variable region binding fragments exhibit optimized activity compared to donor heteromeric variable regions and have unvaried human frameworks. The present invention also provides methods of making the optimized heteromeric variable region binding fragments.
摘要翻译： 本发明提供了优化的异源可变区结合片段和包含优化的异聚可变区结合片段的抗体。 优选地，优化的异聚可变区结合片段与供体异聚体可变区相比表现出优化的活性并且具有不变的人框架。 本发明还提供了制备优化的异源可变区结合片段的方法。
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公开(公告)号：US07575747B2
公开(公告)日：2009-08-18
申请号：US10544050
申请日：2004-02-06
申请人： Julian Davies , Ying Tang , Jeffry Dean Watkins
发明人： Julian Davies , Ying Tang , Jeffry Dean Watkins
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarity determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prevention of conditions and diseases associated with Aβ, including Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like.
摘要翻译： 本发明包括使用衍生自鼠抗体266的互补决定区的鼠抗体266的人源化变体的分离的抗体或其片段。变体抗体可用于治疗或预防与Aβ相关的病症和疾病，包括阿尔茨海默氏病 唐氏综合征，脑淀粉样血管病，轻度认知障碍等。
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公开(公告)号：US08105597B2
公开(公告)日：2012-01-31
申请号：US12504818
申请日：2009-07-17
申请人： Julian Davies , Ying Tang , Jeffry Dean Watkins
发明人： Julian Davies , Ying Tang , Jeffry Dean Watkins
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarily determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prevention of conditions and diseases associated with Aβ, including Alzheimer's disease. Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like.
摘要翻译： 本发明包括分离的抗体或其片段，其是使用来自鼠抗体266的互补决定区的鼠抗体266的人源化变体。变体抗体可用于治疗或预防与A＆bgr相关的病症和疾病，包括阿尔茨海默病 疾病。 唐氏综合征，脑淀粉样血管病，轻度认知障碍等。
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公开(公告)号：US08623365B2
公开(公告)日：2014-01-07
申请号：US13332753
申请日：2011-12-21
申请人： Julian Davies , Ying Tang , Jeffry Dean Watkins
发明人： Julian Davies , Ying Tang , Jeffry Dean Watkins
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarity determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prevention of conditions and diseases associated with Aβ, including Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like.
摘要翻译： 本发明包括使用衍生自鼠抗体266的互补决定区的鼠抗体266的人源化变体的分离的抗体或其片段。变体抗体可用于治疗或预防与Aβ相关的病症和疾病，包括阿尔茨海默氏病 唐氏综合征，脑淀粉样血管病，轻度认知障碍等。
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公开(公告)号：US07740847B2
公开(公告)日：2010-06-22
申请号：US11572634
申请日：2005-07-18
申请人： Barrett Allan , Weidong Jiang , Ying Tang , Jeffry Dean Watkins
发明人： Barrett Allan , Weidong Jiang , Ying Tang , Jeffry Dean Watkins
CPC分类号： C07K16/2887 , C07K16/2896 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The present invention provides humanized anti-CD20 antibodies comprising a human IgG1 Fc region comprising an isoleucine at position 247 and a glutamine at position 339 as well as nucleic acids encoding the antibodies and methods of using the antibodies for treating lymphoma. Furthermore, the invention provides compositions comprising the antibodies and methods of producing them.
摘要翻译： 本发明提供了人源化的抗CD20抗体，其包含含有247位异亮氨酸和339位谷氨酰胺的人IgG1 Fc区以及编码该抗体的核酸以及使用该抗体治疗淋巴瘤的方法。 此外，本发明提供包含抗体的组合物及其生产方法。
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公开(公告)号：US20090297505A1
公开(公告)日：2009-12-03
申请号：US12504818
申请日：2009-07-17
申请人： Julian Davies , Ying Tang , Jeffry Dean Watkins
发明人： Julian Davies , Ying Tang , Jeffry Dean Watkins
IPC分类号： A61K39/395 , C07K16/18 , A61P25/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present invention encompasses isolated antibodies, or fragments thereof, that are humanized variants of murine antibody 266 which employ complementarily determining regions derived from murine antibody 266. The variant antibodies are useful for treatment or prevention of conditions and diseases associated with Aβ, including Alzheimer's disease. Down's syndrome, cerebral amyloid angiopathy, mild cognitive impairment, and the like.
摘要翻译： 本发明包括分离的抗体或其片段，其是使用来自鼠抗体266的互补决定区的鼠抗体266的人源化变体。变体抗体可用于治疗或预防与Aβ相关的病症和疾病，包括阿尔茨海默氏病 。 唐氏综合征，脑淀粉样血管病，轻度认知障碍等。
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8.发明授权Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tryptophanyl-tRNA synthetases 有权与色氨酰-tRNA合成酶的蛋白质片段相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US09399770B2
公开(公告)日：2016-07-26
申请号：US13877899
申请日：2011-10-06
申请人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C12N9/93 , A61K38/00 , A61K38/53 , C07K16/40 , C07K2317/21 , C07K2317/92 , C12Y601/01
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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公开(公告)号：US08828395B2
公开(公告)日：2014-09-09
申请号：US13162559
申请日：2011-06-16
申请人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
发明人： Jeffry Dean Watkins , Alain P. Vasserot , Rajesh Belani , Leslie Ann Greene , Ryan Andrew Adams
IPC分类号： A61K39/395 , C07K16/40
CPC分类号： C07K16/40 , A61K38/53 , A61K39/39533 , C07K2317/20 , C07K2317/33 , A61K2300/00
摘要： Hematopoietic-modulating compositions are provided comprising aminoacyl-tRNA synthetase polypeptides, including active fragments and/or variants thereof, as well as compositions comprising related agents such as antibodies and other binding agents. Also provided are methods of using such compositions in the treatment of conditions that benefit from the modulation of hematopoiesis.
摘要翻译： 提供造血调节组合物，其包含氨酰-tRNA合成酶多肽，包括其活性片段和/或变体，以及包含相关试剂如抗体和其它结合剂的组合物。 还提供了使用这些组合物治疗受益于造血细胞调节的病症的方法。
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10.发明申请INNOVATIVE DISCOVERY OF THERAPEUTIC, DIAGNOSTIC, AND ANTIBODY COMPOSITIONS RELATED TO PROTEIN FRAGMENTS OF ALANYL-TRNA SYNTHETASES 有权与ALANYL-TRNA合成蛋白质蛋白相关的治疗，诊断和抗体组合物的创新发现公开(公告)号：US20130287755A1
公开(公告)日：2013-10-31
申请号：US13643753
申请日：2011-04-28
申请人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
发明人： Leslie Ann Greene , Kyle P. Chiang , Fei Hong , Alain Philippe Vasserot , Wing-Sze Lo , Jeffry Dean Watkins , Cheryl L. Quinn , John D. Mendlein
CPC分类号： C07K16/40 , A61K35/12 , A61K38/00 , A61K38/53 , C07K14/00 , C07K2317/24 , C07K2317/622 , C07K2319/33 , C12N5/0602 , C12N9/18 , C12N9/93 , C12N9/96 , C12Y601/01 , C12Y601/01007 , G01N33/5008 , G01N33/573 , G01N33/68 , G01N2333/9015 , G01N2500/00
摘要： Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
摘要翻译： 提供了包含新确定的氨酰-tRNA合成酶的蛋白质片段的组合物，编码它们的多核苷酸及其补体，相关试剂及其在诊断，药物发现，研究和治疗应用中的使用方法。
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