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    Ion exchanger for lipoproteins separation and lipoproteins separation method using the same
    1.
    发明授权
    Ion exchanger for lipoproteins separation and lipoproteins separation method using the same 失效
    用于脂蛋白分离的离子交换剂和使用其的脂蛋白分离方法

    公开(公告)号：US07022744B2

    公开(公告)日：2006-04-04

    申请号：US10410398

    申请日：2003-04-10

    申请人： Jun Haginaka ,  Masaru Sano ,  Tsunehiko Kurata

    发明人： Jun Haginaka ,  Masaru Sano ,  Tsunehiko Kurata

    IPC分类号： C08J5/20

    CPC分类号： B01J41/14 ,  B01D15/362 ,  B01D15/363 ,  B01J39/20 ,  Y10S530/83

    摘要： A composition useful for separating lipoproteins, such as high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL) and modified lipoproteins with a high degree of accuracy by ion-exchange based procedures. The composition comprises an organic particle having a hydrophilic surface onto which ion-exchange groups are introduced and which is formulated so as to provide a high enough degree of hydrophilicity to prevent irreversible absorption of lipoproteins, but which is not so high as to block the pores of the ion exchange particles and prevent adequate retention and separation of lipoproteins. A method for making a composition for separating lipoproteins comprising seed polymerization of organic particles, hydrophilic treatment of the organic particles by introducing 0.1-45% of a compound (B) having a cyclic ether group and/or a hydrophilic group and a polymerizable unsaturated double bond into organic polymer particles (A) by an addition reaction, and copolymerizing with the addition product of (A) and (B) 5-60% of a polymerizable vinyl monomer (C) having a cyclic ether group or/and a hydrophilic group to form particles (D) having a hydrophilic surface, and introducing an ion exchange group in an amount ranging from 0.15 milliequivalent or less per 1 g of dry particles (D).

    摘要翻译： 通过基于离子交换的方法，可以高精度地分离脂蛋白，例如高密度脂蛋白（HDL），低密度脂蛋白（LDL），极低密度脂蛋白（VLDL）和修饰的脂蛋白。 该组合物包含具有亲水表面的有机颗粒，其上引入了离子交换基团，并且其被配制为提供足够高的亲水性以防止脂蛋白的不可逆吸收，但是其不会阻塞孔 的离子交换颗粒，并防止脂蛋白的充分保留和分离。 一种制备用于分离脂蛋白的组合物的方法，包括有机颗粒的种子聚合，通过引入0.1-45％的具有环状醚基和/或亲水基团的化合物（B）和/或可聚合不饱和双键来亲水处理有机颗粒 通过加成反应与有机聚合物粒子（A）键合，并与（A）和（B）的加成物与5-20％的具有环状醚基或/和亲水基团的可聚合乙烯基单体（C） 以形成具有亲水性表面的颗粒（D），并且以每1g干燥颗粒（D）为0.15毫当量或更小的量引入离子交换基团。

    Method for producing a spherical ion exchange resin
    2.
    发明授权
    Method for producing a spherical ion exchange resin 失效
    球形离子交换树脂的制造方法

    公开(公告)号：US5637627A

    公开(公告)日：1997-06-10

    申请号：US603093

    申请日：1996-02-20

    申请人： Junya Watanabe ,  Tsunehiko Kurata

    发明人： Junya Watanabe ,  Tsunehiko Kurata

    IPC分类号： B01J39/20 ,  C08F4/38 ,  C08F8/00 ,  C08F212/04 ,  C08F8/36 ,  C08F4/36 ,  C08F8/32

    CPC分类号： C08F212/04 ,  B01J39/20 ,  C08F4/38 ,  C08F8/36 ,  C08F8/44

    摘要： A method for producing a spherical crosslinked copolymer, which comprises polymerizing a monofunctional addition-polymerizable monomer and at least 0.5% by weight of a polyfunctional addition-polymerizable monomer on the basis of the total weight of monomers by suspension polymerization in an aqueous medium in the presence of a radical polymerization initiator of the following formula (b) which has a decomposition temperature for a half-life period of 10 hours within a range of from 60.degree. to 120.degree. C. and which is capable of forming at least four radical initiating points per molecule by the decomposition:(R.sub.4 --O--O.paren close-st..sub.m R.sub.5 (b)wherein R.sub.4 is a linear or branched C.sub.1-10 alkyl group, R.sub.5 is a m-valent C.sub.4-25 hydrocarbon group, and m is an integer of at least 2, wherein the plurality of R.sub.4 per molecule may be the same or different.

    摘要翻译： 一种球形交联共聚物的制备方法，其包括使单官能加成聚合单体和至少0.5重量％的多官能加成聚合单体以单体的总重量为基础，通过在 存在下述式（b）的自由基聚合引发剂，其在60℃至120℃的范围内具有10小时的半衰期的分解温度，并且能够形成至少四个自由基引发剂 （R4-O-O + 546mR5（b））其中R4是直链或支链C1-10烷基，R5是m价C4-25烃基，m是整数 至少2个，其中每个分子的多个R 4可以相同或不同。