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    Methods For Producing Dendritic Cells That Have Acquired Ctl-Inducing Ability
    1.
    发明申请
    Methods For Producing Dendritic Cells That Have Acquired Ctl-Inducing Ability 审中-公开
    生产获得Ctl诱导能力的树突状细胞的方法

    公开(公告)号：US20080194020A1

    公开(公告)日：2008-08-14

    申请号：US11574641

    申请日：2005-09-02

    申请人： Jun Imai ,  Mikako Maruya ,  Shigeo Koyasu ,  Hironori Hasegawa ,  Ichiro Yahara

    发明人： Jun Imai ,  Mikako Maruya ,  Shigeo Koyasu ,  Hironori Hasegawa ,  Ichiro Yahara

    IPC分类号： C12N5/06 ,  C07K14/435 ,  C07H21/04 ,  C12N15/63

    CPC分类号： C12N5/0639 ,  C12N2501/07

    摘要： The present inventors worked on elucidating the mechanism of antigen cross-presentation by dendritic cells, and revealed that foreign antigens taken up in dendritic cells are degraded by proteasomes after undergoing polyubiquitination. Based on the novel finding that polyubiquitination is involved in cross-presentation, the promotion of polyubiquitination was attempted by a number of methods, and the promotion of antigen presentation was confirmed. These methods enable the production of dendritic cells effective for inducing CTL activation.

    摘要翻译： 本发明人致力于阐明树突状细胞抗原交叉呈递的机理，并揭示在经历多聚泛素化后，被树突状细胞吸收的外源抗原被蛋白酶体降解。 基于多泛素化涉及交叉表达的新发现，通过多种方法尝试促进多泛素化，证实了抗原呈递的促进作用。 这些方法能够产生有效诱导CTL活化的树突状细胞。

    Methods for Selecting Proteins that are Readily Presented as Antigens on Dendritic Cells
    2.
    发明申请
    Methods for Selecting Proteins that are Readily Presented as Antigens on Dendritic Cells 审中-公开
    选择易于树突状细胞抗原的蛋白质的选择方法

    公开(公告)号：US20080064048A1

    公开(公告)日：2008-03-13

    申请号：US11574612

    申请日：2005-09-02

    申请人： Jun Imai ,  Mikako Maruya ,  Shigeo Koyasu ,  Hironori Hasegawa ,  Ichiro Yahara

    发明人： Jun Imai ,  Mikako Maruya ,  Shigeo Koyasu ,  Hironori Hasegawa ,  Ichiro Yahara

    IPC分类号： G01N33/567 ,  C12N5/02

    CPC分类号： C12N5/0639 ,  G01N33/5047

    摘要： The present inventors worked on elucidating the mechanism of antigen cross-presentation by dendritic cells, and revealed that foreign antigens taken up in dendritic cells are degraded by proteasomes after undergoing polyubiquitination. They discovered a positive correlation between the uptake amount of an antigenic protein by dendritic cells or the level of polyubiquitination and the level of antigen presentation of the antigenic protein. Based on these findings, methods were developed for predicting the intensity of cross-presentation of an anti genic protein by measuring the amount of antigenic protein taken up or polyubiquitinated protein. The use of these methods allows selecting antigenic proteins that are readily presented as antigens from among a number of proteins. The methods of the present invention enable suitable cancer immune vaccines to be provided through selection of more suitable cancer-specific proteins.

    摘要翻译： 本发明人致力于阐明树突状细胞抗原交叉呈递的机理，并揭示在经历多聚泛素化后，被树突状细胞吸收的外源抗原被蛋白酶体降解。 他们发现树突状细胞的抗原蛋白摄取量或多聚泛素化水平与抗原蛋白的抗原呈递水平呈正相关。 基于这些发现，开发了通过测量抗原蛋白摄取或多聚泛素化蛋白的量来预测抗基因蛋白的交叉表达强度的方法。 使用这些方法允许从许多蛋白质中选择容易呈现为抗原的抗原蛋白质。 本发明的方法通过选择更合适的癌症特异性蛋白质来提供合适的癌症免疫疫苗。

    Methods for selecting candidate peptides presented on the surface of cancer cells following their binding to MHC class I molecules
    3.
    发明申请
    Methods for selecting candidate peptides presented on the surface of cancer cells following their binding to MHC class I molecules 审中-公开
    选择在与MHC I类分子结合后，癌细胞表面呈现的候选肽的方法

    公开(公告)号：US20090280511A1

    公开(公告)日：2009-11-12

    申请号：US12313855

    申请日：2008-11-25

    申请人： Ichiro Yahara ,  Shigeo Koyasu ,  Jun Imai

    发明人： Ichiro Yahara ,  Shigeo Koyasu ,  Jun Imai

    IPC分类号： G01N33/574 ,  G06G7/60

    CPC分类号： G01N33/5011 ,  G01N2333/70539

    摘要： An objective of the present invention is to provide methods for selecting candidate peptides presented on the surface of cancer cells following binding to MHC class I molecules, wherein the peptides are involved in the stimulation of T cell immunity (cellular immunity). The present inventors discovered a new principle of MHC I-mediated antigen presentation in which a T cell antigen epitope is more efficiently presented on MHC I molecules when it is positioned at the N-terminal side than when positioned at the C-terminal side.

    摘要翻译： 本发明的目的是提供用于选择在与MHC I类分子结合之后呈现在癌细胞表面上的候选肽的方法，其中所述肽参与T细胞免疫（细胞免疫）的刺激。 本发明人发现了MHC I介导的抗原呈递的新原理，其中当位于N末端侧时，当位于C末端侧时，T细胞抗原表位在MHC I分子上更有效地呈现。

    Thermochromic toy for revealing hidden codes
    7.
    发明申请
    Thermochromic toy for revealing hidden codes 审中-公开
    热变色玩具，用于揭示隐藏的代码

    公开(公告)号：US20070259592A1

    公开(公告)日：2007-11-08

    申请号：US11418683

    申请日：2006-05-04

    申请人： Jun Imai ,  Alec Tam

    发明人： Jun Imai ,  Alec Tam

    IPC分类号： A63H33/00

    CPC分类号： A63H33/22

    摘要： A product, comprising a toy; and the toy including a thermochromic region on at least a portion of the toy, where the thermochromic region exhibits a visual change in response to temperature; a code, wherein the thermochromic region reveals a human readable code upon the visual change; and a decoder for decoding the code is provided.

    摘要翻译： 一种产品，包括玩具; 并且所述玩具在所述玩具的至少一部分上包括热变色区域，其中所述热变色区域响应于温度呈现视觉变化; 代码，其中热变色区域在视觉变化时显示人类可读代码; 并提供用于对代码进行解码的解码器。

    Molding condition optimizing system for injection molding machine
    9.
    发明授权
    Molding condition optimizing system for injection molding machine 失效
    注塑机成型条件优化系统

    公开(公告)号：US5900259A

    公开(公告)日：1999-05-04

    申请号：US643474

    申请日：1996-05-06

    申请人： Yoji Miyoshi ,  Hiroharu Orita ,  Kenji Hayakawa ,  Jun Imai ,  Koei Ozeki

    发明人： Yoji Miyoshi ,  Hiroharu Orita ,  Kenji Hayakawa ,  Jun Imai ,  Koei Ozeki

    IPC分类号： B29C33/38 ,  B29C45/76 ,  B29C45/77

    CPC分类号： B29C45/766 ,  B29C33/3835 ,  B29C45/768 ,  B29C45/7693 ,  B29C2045/776

    摘要： A molding condition optimizing system for an injection molding machine comprising plastic flow condition optimizing section and an operating condition determining section is disclosed. The plastic flow condition optimizing section carries out a plastic flow analysis on a molded part model, and determines an optimum flow condition in a filling stage and a packing stage of an injection molding process of the injection molding machine by repeatedly executing an automated calculation using the result of the plastic flow analysis and the plastic flow analysis itself. The operating condition determining section comprises an injection-side condition determining section for determining an optimum injection-side condition of the injection molding machine according to the optimum flow condition obtained by the plastic flow condition optimizing means and a knowledge database with respect to an injection condition, and a clamping-side condition determining section for determining an optimum clamping-side condition according to the molded part form data generated by the plastic flow condition optimizing means, the result of the plastic flow analysis, mold design data, and a knowledge database with respect to a mold clamping condition.

    摘要翻译： 公开了一种用于注射成型机的成型条件优化系统，其包括塑性流动条件优化部分和操作条件确定部分。 塑性流动条件优化部分对模制零件模型进行塑性流动分析，并通过重复执行自动计算来确定注射成型机的注塑过程的填充阶段和填充阶段的最佳流动状态 塑料流动分析和塑性流动分析本身的结果。 操作条件确定部分包括注射侧条件确定部分，用于根据由塑性流条件优化装置获得的最佳流动条件和关于注射条件的知识数据库确定注射成型机的最佳注射侧条件 以及夹持侧条件决定部，其根据由塑性流动条件优化装置生成的模制部件形状数据，塑性流动分析的结果，模具设计数据和知识数据库确定最佳夹持侧条件， 相对于模具夹紧条件。