利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

16 条记录 (耗时 0.016 秒)

    Quinoline derivatives, pharmaceutical composition and method of use
    2.
    发明授权
    Quinoline derivatives, pharmaceutical composition and method of use 失效
    喹啉衍生物，药物组合物和使用方法

    公开(公告)号：US4886810A

    公开(公告)日：1989-12-12

    申请号：US042806

    申请日：1987-04-27

    申请人： Jun-ichi Matsumoto ,  Teruyuki Miyamoto ,  Hiroshi Egawa ,  Shinichi Nakamura

    发明人： Jun-ichi Matsumoto ,  Teruyuki Miyamoto ,  Hiroshi Egawa ,  Shinichi Nakamura

    IPC分类号： A61K31/47 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61P31/04 ,  C07D215/56 ,  C07D401/04 ,  C07D413/04

    CPC分类号： C07D215/56 ,  C07D401/04

    摘要： The present invention relates to quinoline derivatives of the formula ##STR1## wherein Z is an amino group or a halogen atom, R is ##STR2## in which R.sub.1 is a hydrogen atom, a lower alkyl or haloalkyl group, R.sub.2 is a hydrogen atom or a lower alkyl group, R.sub.3 is a lower alkyl or haloalkyl group, R.sub.4 is a hydrogen atom or a lower alkyl group, R.sub.5 and R.sub.6 are the same or different and each represents a hydrogen atom or a lower alkyl group, or R.sub.5 and R.sub.6, together with the nitrogen atom to which they are attached, form a heterocyclic ring, and n is 0 or 1, with the proviso that when Z is an amino group, R is (B);and esters thereof and salts thereof and processes for preparation thereof. These compounds show excellent antibacterial activity and are useful antibacterial agents.

    摘要翻译： 本发明涉及式（I）的喹啉衍生物，其中Z为氨基或卤素原子，R为（A）或（IMA）（B），其中R 1为氢原子， 低级烷基或卤代烷基，R2为氢原子或低级烷基，R3为低级烷基或卤代烷基，R4为氢原子或低级烷基，R5和R6相同或不同，分别表示 氢原子或低级烷基，或R 5和R 6与它们所连接的氮原子一起形成杂环，n为0或1，条件是当Z为氨基时，R为（ B）; 及其酯及其盐及其制备方法。 这些化合物显示出优异的抗菌活性，并且是有用的抗菌剂。

    Naphthyridine derivatives and their use as anti-bacterials
    4.
    发明授权
    Naphthyridine derivatives and their use as anti-bacterials 失效
    萘啶衍生物及其作为抗菌剂的用途

    公开(公告)号：US4382937A

    公开(公告)日：1983-05-10

    申请号：US351924

    申请日：1982-02-24

    申请人： Jun-ichi Matsumoto ,  Shinichi Nakamura

    发明人： Jun-ichi Matsumoto ,  Shinichi Nakamura

    IPC分类号： C07D213/75 ,  C07D213/77 ,  C07D471/04 ,  A61K31/44

    CPC分类号： C07D213/75 ,  C07D213/77 ,  C07D471/04

    摘要： A 1,8-naphthyridine compound of the formula ##STR1## wherein R is a vinyl or 2-fluoroethyl group, andR.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or a lower alkyl group having 1 to 4 carbon atoms,and the esters thereof and salts thereof. For example, 7-(3-amino-1-pyrrolidinyl)-6-fluoro-1,4-dihydro-4-oxo-1-vinyl-1,8-naphthyridine-3-carboxylic acid and nontoxic salts thereof, which are covered by the aforesaid compound, are useful as an antibacterial agent.

    摘要翻译： 式（I）的1,8-萘啶化合物，其中R是乙烯基或2-氟乙基，R 1和R 2相同或不同，各自表示氢原子或具有1〜 4个碳原子，以及它们的酯及其盐。 例如，7-（3-氨基-1-吡咯烷基）-6-氟-1,4-二氢-4-氧代-1-乙烯基-1,8-萘啶-3-羧酸及其无毒盐，其中 被上述化合物覆盖，可用作抗菌剂。

    Antibacterial pharmaceutical compositions and processes for preparation thereof
    10.
    发明授权
    Antibacterial pharmaceutical compositions and processes for preparation thereof 失效
    抗菌药物组合物及其制备方法

    公开(公告)号：US3962443A

    公开(公告)日：1976-06-08

    申请号：US551923

    申请日：1975-02-21

    申请人： Shinsaku Minami ,  Jun-ichi Matsumoto ,  Kazuyo Kawaguchi ,  Shinsaku Mishio ,  Masanao Shimizu ,  Yoshiyuki Takase ,  Shinichi Nakamura

    发明人： Shinsaku Minami ,  Jun-ichi Matsumoto ,  Kazuyo Kawaguchi ,  Shinsaku Mishio ,  Masanao Shimizu ,  Yoshiyuki Takase ,  Shinichi Nakamura

    IPC分类号： A61K31/505

    摘要： This invention provides compounds of the following formula ##SPC1##Wherein R.sub.1 is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a hydroxyalkyl group having 2 to 4 carbon atoms, a benzyl group, a benzyl group subsituted by methoxy, a phenyl group, a propargyl group or an acyl group; R.sub.2 is hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an alkyl group having 2 to 4 carbon atoms substituted by hydroxy or halogen, a vinyl group, an allyl group, or a benzyl group R.sub.3 is a hydrogen atom or an alkyl group having 1 to 6 carbon atoms;And salts thereof, and processes for preparing them. Some of the compounds have antibacterial activities.

    摘要翻译： 本发明提供下式的化合物，其中R 1是氢原子，具有1至4个碳原子的烷基，具有2至4个碳原子的羟基烷基，苄基，被甲氧基取代的苄基，苯基， 炔丙基或酰基; R2为氢原子，碳原子数为1〜4的烷基，被羟基或卤素取代的碳原子数为2〜4的烷基，乙烯基，烯丙基或苄基R 3为氢原子或烷基 具有1至6个碳原子的基团; 及其制备方法及其制备方法。 一些化合物具有抗菌活性。