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8 条记录 (耗时 0.029 秒)

    Apoptosis inhibitor
    1.
    发明授权
    Apoptosis inhibitor 失效
    凋亡抑制剂

    公开(公告)号：US06399639B1

    公开(公告)日：2002-06-04

    申请号：US09519274

    申请日：2000-03-07

    申请人： Junji Matsui ,  Naoki Tarui ,  Yu Momose ,  Ken-ichi Naruo

    发明人： Junji Matsui ,  Naoki Tarui ,  Yu Momose ,  Ken-ichi Naruo

    IPC分类号： A61K31427

    CPC分类号： A61K31/427 ,  A61K31/422 ,  A61K31/425 ,  A61K31/4439

    摘要： An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: —CO—, —CH(OH)— or —NR3— where R3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R1; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.

    摘要翻译： 一种凋亡抑制剂，其包含下式化合物：其中R表示可被取代的烃基或可被取代的杂环基; Y表示式-CO-，-CH（OH） - 或-NR 3 - ，其中R 3表示可被取代的烷基; m为0或1; n为0,1或2; X表示CH或N; A表示化学键或碳原子数为1〜7的二价脂肪族烃基; Q表示氧或硫; R1表示氢或烷基; 环E可以具有另外1至4个取代基，其可以与R 1组合形成环; L和M分别表示氢或可以相互结合形成化学键; 或其盐，或具有胰岛素敏感性增强活性的化合物。

    Apoptosis inhibitor
    2.
    发明授权
    Apoptosis inhibitor 失效

    公开(公告)号：US06555565B2

    公开(公告)日：2003-04-29

    申请号：US10047816

    申请日：2002-01-15

    申请人： Junji Matsui ,  Naoki Tarui ,  Yu Momose ,  Ken-ichi Naruo

    发明人： Junji Matsui ,  Naoki Tarui ,  Yu Momose ,  Ken-ichi Naruo

    IPC分类号： A61K31427

    CPC分类号： A61K31/427 ,  A61K31/422 ,  A61K31/425 ,  A61K31/4439

    摘要： An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: —CO—, —CH(OH)— or —NR3— where R3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R1; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.

    Apoptosis inhibitor
    3.
    发明授权
    Apoptosis inhibitor 有权
    凋亡抑制剂

    公开(公告)号：US6087384A

    公开(公告)日：2000-07-11

    申请号：US272747

    申请日：1999-03-15

    申请人： Junji Matsui ,  Naoki Tarui ,  Yu Momose ,  Ken-ichi Naruo

    发明人： Junji Matsui ,  Naoki Tarui ,  Yu Momose ,  Ken-ichi Naruo

    IPC分类号： A61K31/422 ,  A61K31/425 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/444 ,  C07D413/02 ,  C07D413/14 ,  C07D417/02 ,  C07D417/14 ,  A01K31/426 ,  A01K31/427

    CPC分类号： A61K31/427 ,  A61K31/422 ,  A61K31/425 ,  A61K31/4439

    摘要： An apoptosis inhibitor which comprises a compound of the formula: wherein R represents a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; Y represents a group of the formula: --CO--, --CH(OH)-- or --NR.sup.3 -- where R.sup.3 represents an alkyl group that may be substituted; m is 0 or 1; n is 0, 1 or 2; X represents CH or N; A represents a chemical bond or a bivalent aliphatic hydrocarbon group having 1 to 7 carbon atoms; Q represents oxygen or sulfur; R.sup.1 represents hydrogen or an alkyl group; ring E may have further 1 to 4 substituents, which may form a ring in combination with R.sup.1 ; L and M respectively represent hydrogen or may be combined with each other to form a chemical bond; or a salt thereof, or a compound having an insulin sensitivity enhancing activity.

    摘要翻译： 一种凋亡抑制剂，其包含下式化合物：其中R表示可被取代的烃基或可被取代的杂环基; Y表示式-CO-，-CH（OH） - 或-NR 3 - ，其中R 3表示可被取代的烷基; m为0或1; n为0,1或2; X表示CH或N; A表示化学键或碳原子数为1〜7的二价脂肪族烃基; Q表示氧或硫; R1表示氢或烷基; 环E可以具有另外1至4个取代基，其可以与R 1组合形成环; L和M分别表示氢或可以相互结合形成化学键; 或其盐，或具有胰岛素敏感性增强活性的化合物。

    Aromatic hydroxamix acid compounds, their production and use
    5.
    发明授权
    Aromatic hydroxamix acid compounds, their production and use 失效
    芳香族异羟肟酸化合物，其生产和使用

    公开(公告)号：US5891916A

    公开(公告)日：1999-04-06

    申请号：US662240

    申请日：1996-06-14

    申请人： Kaneyoshi Kato ,  Yoshihiro Sugiura ,  Ken-ichi Naruo ,  Hideki Takahashi

    发明人： Kaneyoshi Kato ,  Yoshihiro Sugiura ,  Ken-ichi Naruo ,  Hideki Takahashi

    IPC分类号： C07C259/06 ,  C07C271/60 ,  C07D277/30 ,  C07C239/08 ,  A61K31/19 ,  C07D277/00

    CPC分类号： C07C271/60 ,  C07C259/06

    摘要： A compound represented by the formula: ##STR1## wherein Ar.sup.1 and Ar.sup.2 independently represent an optionally substituted aromatic group; Q represents an optionally substituted divalent aliphatic hydrocarbon group optionally containing O or S; R.sup.1 represents H, acyl group, etc.; and X represents an electron-withdrawing group, an optionally substituted aromatic group, a group of the formula: ##STR2## wherein R.sup.2 and R.sup.3 independently represent H, acyl group or an optionally substituted hydrocarbon group, etc., etc.; or salts thereof are useful as an excellent anti-neurodegenerative agent.

    摘要翻译： 由下式表示的化合物：其中Ar 1和Ar 2独立地表示任选取代的芳基; Q表示任选含有O或S的任选取代的二价脂族烃基; R1代表H，酰基等; X表示吸电子基团，可以具有取代基的芳基，下式的基团：其中R2和R3独立地表示H，酰基或任意取代的烃基等; 或其盐可用作优异的抗神经变性剂。

    Substituted 1,3-thiazole compounds, their production and use
    6.
    发明授权
    Substituted 1,3-thiazole compounds, their production and use 失效
    取代的1,3-噻唑化合物，其生产和使用

    公开(公告)号：US07495018B2

    公开(公告)日：2009-02-24

    申请号：US10239692

    申请日：2001-03-29

    申请人： Shigenori Ohkawa ,  Ken-ichi Naruo ,  Seiji Miwatashi ,  Hiroyuki Kimura

    发明人： Shigenori Ohkawa ,  Ken-ichi Naruo ,  Seiji Miwatashi ,  Hiroyuki Kimura

    IPC分类号： A61K31/4436 ,  C07D417/04

    CPC分类号： C07D417/04

    摘要： (1) A 1,3-thiazole compound of which the 5-position is substituted with a 4-pyridyl group having a substituent including no aromatic group or (2) a 1,3-thiazole compound of which the 5-position is substituted with a pyridyl group having at the position adjacent to a nitrogen atom of the pyridyl group a substituent including no aromatic group has an excellent p38 MAP kinase inhibitory activity.

    摘要翻译： （1）5-取代的不具有芳香族基团的取代基的4-吡啶基的1,3-噻唑化合物或（2）取代有5位的1,3-噻唑化合物 在与吡啶基的氮原子相邻的位置具有吡啶基的情况下，不含芳香族基团的取代基具有优异的p38MAP激酶抑制活性。