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    ANTIBODY SPECIFIC TO INTACT HUMAN AUTOTAXIN, METHOD OF SCREENING THE SAME AND METHOD AND REAGENT FOR EXAMINING MALIGNANT LYMPHOMA BY ASSAYING AUTOTAXIN
    1.
    发明申请
    ANTIBODY SPECIFIC TO INTACT HUMAN AUTOTAXIN, METHOD OF SCREENING THE SAME AND METHOD AND REAGENT FOR EXAMINING MALIGNANT LYMPHOMA BY ASSAYING AUTOTAXIN 审中-公开
    抗人体免疫球蛋白的特异性检测方法，筛选方法和方法以及通过测定自身免疫性检测恶性淋巴瘤的试剂

    公开(公告)号：US20100120064A1

    公开(公告)日：2010-05-13

    申请号：US12376188

    申请日：2007-08-02

    申请人： Junken Aoki ,  Hiroyuki Arai ,  Yutaka Yatomi ,  Hitoshi Ikeda ,  Kazuhiro Nakamura ,  Koji Igarashi ,  Kazufumi Ide

    发明人： Junken Aoki ,  Hiroyuki Arai ,  Yutaka Yatomi ,  Hitoshi Ikeda ,  Kazuhiro Nakamura ,  Koji Igarashi ,  Kazufumi Ide

    IPC分类号： G01N33/573 ,  G01N33/566 ,  G01N33/53 ,  C07K16/18

    CPC分类号： G01N33/564 ,  C07K16/28 ,  C07K16/40 ,  C07K2317/34 ,  C07K2317/76 ,  G01N33/573 ,  G01N2333/916

    摘要： A screening method is provided for antibody specifically recognizing naturally-occurring form of human autotaxin in a state in which it is present in the body without being denatured, comprising the steps of: binding a binding factor capable of capturing a candidate antibody of the antibody to a solid phase; binding the candidate antibody of the antibody to the binding factor; allowing naturally-occurring form of human autotaxin to react on a system in which the candidate antibody has reacted; and selecting an antibody that specifically recognizes the naturally-occurring form of human autotaxin by using as an indicator thereof the binding strength of the naturally-occurring form of human autotaxin to the antibody. Moreover, a detecting method for malignant lymphoma is provided comprising: measuring the concentration of autotaxin in a human specimen, and judging to be a malignant lymphoma in the case that value exhibits a significantly higher value than normal values comprised of measured values from normal healthy subjects.

    摘要翻译： 本发明提供一种筛选方法，该抗体特异性识别天然存在形式的人体自体贴剂在体内不变性的状态下，包括以下步骤：将能够将抗体候选抗体捕获的结合因子与 固相; 将抗体的候选抗体结合至结合因子; 允许天然存在的人自体吸收素形式在候选抗体已经反应的系统上反应; 并且通过使用天然存在形式的人自身加样蛋白与抗体的结合强度来选择特异性识别天然存在形式的人自体添加素的抗体。 此外，提供了一种用于恶性淋巴瘤的检测方法，其包括：测量人标本中自体吸收素的浓度，并且在值与正常健康受试者的测量值相比显示出比正常值显着更高的值时判断为恶性淋巴瘤 。