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    Method for inhibition of cell motility by sphingosine-1-phosphate and its derivatives
    2.
    发明授权
    Method for inhibition of cell motility by sphingosine-1-phosphate and its derivatives 失效
    抑制鞘氨醇-1-磷酸及其衍生物的细胞运动性的方法

    公开(公告)号：US5877167A

    公开(公告)日：1999-03-02

    申请号：US797926

    申请日：1997-02-12

    申请人： Yasuyuki Igarashi ,  Fugiang Ruan ,  Yoshito Sadahira ,  Shigeyuki Kawa ,  Sen-itiroh Hakomori

    发明人： Yasuyuki Igarashi ,  Fugiang Ruan ,  Yoshito Sadahira ,  Shigeyuki Kawa ,  Sen-itiroh Hakomori

    IPC分类号： A61K31/66 ,  A61P35/00 ,  C07F9/10 ,  C07F9/113 ,  C07F9/173

    CPC分类号： A61K31/6615 ,  A61K31/66 ,  A61K31/661 ,  C07F9/113 ,  C07F9/173

    摘要： A method of inhibiting tumor cell chemotactic motility and/or chemoinvasion, a method of inhibiting phagokinetic activity of tumor cells and neutrophils, a method of inhibiting tumor cell metastasis and a method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising contacting the cells or administering to a host in need of treatment an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives is also described.

    摘要翻译： 一种抑制肿瘤细胞趋化运动和/或化学侵蚀的方法，抑制肿瘤细胞和嗜中性粒细胞的吞噬作用的方法，抑制肿瘤细胞转移的方法以及抑制由于运动和侵入嗜中性粒细胞血管壁引起的炎症的方法，包括 使细胞接触或向需要治疗的宿主施用抑制量的选自鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1-磷酸的模拟物的药剂，或 衍生物和药学上可接受的盐。 还描述了制备鞘氨醇-1-磷酸酯及其衍生物的方法。

    Sphingosine-1-phosphate essentially free of L-threo isomer
    3.
    发明授权
    Sphingosine-1-phosphate essentially free of L-threo isomer 失效
    基本上不含L-苏式异构体的鞘氨醇-1-磷酸

    公开(公告)号：US5663404A

    公开(公告)日：1997-09-02

    申请号：US371866

    申请日：1995-01-12

    申请人： Yasuyuki Igarashi ,  Fuqiang Ruan ,  Yoshito Sadahira ,  Shigeyuki Kawa ,  Sen-itiroh Hakomori

    发明人： Yasuyuki Igarashi ,  Fuqiang Ruan ,  Yoshito Sadahira ,  Shigeyuki Kawa ,  Sen-itiroh Hakomori

    IPC分类号： A61K31/66 ,  A61P35/00 ,  C07F9/10 ,  C07F9/113 ,  C07F9/173 ,  C07F9/09

    CPC分类号： A61K31/6615 ,  A61K31/66 ,  A61K31/661 ,  C07F9/113 ,  C07F9/173

    摘要： A method of inhibiting tumor cell chemotactic and/or chemoinvasion motility comprising contacting the tumor cell with an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting phagokinetic activity of tumor cells and neutrophils comprising contacting the cells with a phagokinetic inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting tumor cell metastasis comprising administering to a host in need of treatment a metastasis inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising administering to a host in need of treatment an inflammation inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives.

    摘要翻译： 一种抑制肿瘤细胞趋化性和/或化学侵袭运动性的方法，包括使肿瘤细胞与抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物 磷酸盐或衍生物。 一种抑制肿瘤细胞和嗜中性粒细胞的吞噬作用的方法包括使细胞与吞噬动力学抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物 磷酸盐或衍生物。 一种抑制肿瘤细胞转移的方法，包括向需要治疗的宿主施用转移抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物 磷酸盐或其衍生物，以及药学上可接受的盐。 抑制由于运动性而侵入嗜中性粒细胞的血管壁的炎症的方法，包括对需要治疗的宿主施用炎症抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物， 磷酸盐，以及鞘氨醇-1-磷酸酯或衍生物的模拟物，以及药物的药学上可接受的盐。 鞘氨醇-1-磷酸及其衍生物的制备方法。

    Method of preparing N,N,N-trimethylsphingosine
    7.
    发明授权
    Method of preparing N,N,N-trimethylsphingosine 失效
    制备N，N，N-三甲基鞘氨醇的方法

    公开(公告)号：US5248824A

    公开(公告)日：1993-09-28

    申请号：US879332

    申请日：1992-05-07

    申请人： Yasuyuki Igarashi ,  Mahammad N. Ahmad ,  Hirofumi Okoshi ,  Sen-Itiroh Hakomori

    发明人： Yasuyuki Igarashi ,  Mahammad N. Ahmad ,  Hirofumi Okoshi ,  Sen-Itiroh Hakomori

    IPC分类号： C07C215/40

    CPC分类号： C07C215/40

    摘要： The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors), and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.

    摘要翻译： 本发明涉及一种新型化合物，其组合物及其药物，以及抑制细胞增殖，血小板聚集（各种因素诱导），抑制肿瘤细胞恶性表型的方法，使用所述化合物，组合物或 药物。 N，N，N-三甲基鞘氨醇对相关化合物显示出优异的细胞增殖抑制和抗转移活性。

    Method for inhibition of cell motility by sphingosine-1-phosphate and derivatives
    9.
    发明授权
    Method for inhibition of cell motility by sphingosine-1-phosphate and derivatives 失效
    通过鞘氨醇-1-磷酸酯及其衍生物抑制细胞运动的方法

    公开(公告)号：US5260288A

    公开(公告)日：1993-11-09

    申请号：US863179

    申请日：1992-04-03

    申请人： Yasuyuki Igarashi ,  Fugiang Ruan ,  Yoshito Sadahira ,  Shigeyuki Kawa ,  Sen-itiroh Hakomori

    发明人： Yasuyuki Igarashi ,  Fugiang Ruan ,  Yoshito Sadahira ,  Shigeyuki Kawa ,  Sen-itiroh Hakomori

    IPC分类号： A61K31/66 ,  A61P35/00 ,  C07F9/10 ,  C07F9/113 ,  C07F9/173

    CPC分类号： A61K31/6615 ,  A61K31/66 ,  A61K31/661 ,  C07F9/113 ,  C07F9/173

    摘要： A method of inhibiting tumor cell chemotactic and/or chemoinvasion motility comprising contacting the tumor cell with an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting phagokinetic activity of tumor cells and neutrophils comprising contacting the cells with a phagokinetic inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting tumor cell metastasis comprising administering to a host in need of treatment a metastasis inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising administering to a host in need of treatment an inflammation inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives.

    摘要翻译： 一种抑制肿瘤细胞趋化性和/或化学侵袭运动性的方法，包括使肿瘤细胞与抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物 磷酸盐或衍生物。 一种抑制肿瘤细胞和嗜中性粒细胞的吞噬作用的方法包括使细胞与吞噬动力学抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物 磷酸盐或衍生物。 一种抑制肿瘤细胞转移的方法，包括向需要治疗的宿主施用转移抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物 磷酸盐或其衍生物，以及药学上可接受的盐。 抑制由于运动性而侵入嗜中性粒细胞的血管壁的炎症的方法，包括对需要治疗的宿主施用炎症抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物， 磷酸盐，以及鞘氨醇-1-磷酸酯或衍生物的模拟物，以及药剂的药学上可接受的盐。 鞘氨醇-1-磷酸及其衍生物的制备方法。