公开(公告)号：US11072660B2

公开(公告)日：2021-07-27

申请号：US16338452

申请日：2017-10-03

申请人： Juno Therapeutics, Inc.

发明人： James Sissons ,  Cameron Brandt ,  Alexandra Croft ,  Allen Ebens ,  Haley Peper ,  Dean Y. Toy

IPC分类号： C07K14/705 ,  C07K16/28 ,  C07K14/725 ,  C07K16/08 ,  A61P31/20 ,  A61K39/12 ,  A61K39/00

摘要： Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

公开(公告)号：US20210363258A1

公开(公告)日：2021-11-25

申请号：US17384589

申请日：2021-07-23

申请人： Juno Therapeutics, Inc.

发明人： James SISSONS ,  Cameron Brandt ,  Alexandra Croft ,  Allen Ebens ,  Haley Peper ,  Dean Y. Toy

IPC分类号： C07K16/28 ,  C07K14/725 ,  C07K16/08 ,  A61P31/20 ,  A61K39/12

摘要： Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV16 E6 and HPV16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

公开(公告)号：US11952408B2

公开(公告)日：2024-04-09

申请号：US16652379

申请日：2018-09-28

申请人： Juno Therapeutics, Inc. ,  Editas Medicine, Inc.

发明人： Cameron Brandt ,  Brian Belmont ,  Christopher Borges ,  Stephen Michael Burleigh ,  Alexandra Croft ,  Stephen Jacob Goldfless ,  David Jeffrey Huss ,  Yue Jiang ,  Timothy G. Johnstone ,  David Koppstein ,  Hieu Nguyen ,  Christopher Heath Nye ,  Haley Peper ,  Blythe D. Sather ,  Sonia Timberlake ,  Dean Y. Toy ,  Queenie Vong ,  Gordon Grant Welstead ,  James Sissons

IPC分类号： C07K14/705 ,  A61K35/17 ,  A61P31/20 ,  A61P35/00 ,  C07K14/725 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

CPC分类号： C07K14/7051 ,  A61K35/17 ,  A61P31/20 ,  A61P35/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/907 ,  C12N2310/20 ,  C12N2800/80

摘要： Provided are binding molecules, such as TCRs or antigen binding fragments thereof and antibodies and antigen-binding fragments thereof, such as those that recognize or bind human papilloma virus (HPV) 16, including HPV 16 E6 and HPV 16 E7. Also provided are engineered cells containing such binding molecules, compositions containing the binding molecules or engineered cells, and methods of treatment, such as administration of the binding molecules, engineered cells, or compositions.

公开(公告)号：US11471489B2

公开(公告)日：2022-10-18

申请号：US16374729

申请日：2019-04-03

申请人： Juno Therapeutics, Inc.

发明人： Stephen Jacob Goldfless ,  Brian Belmont ,  Cameron Brandt ,  Alexandra Croft ,  David Jeffrey Huss

IPC分类号： A61K35/17 ,  A61P35/00 ,  C07K14/025 ,  C07K14/725 ,  C07K16/08 ,  C12N15/86

摘要： Provided herein are binding molecules, such as those that recognize or bind a peptide epitope of a cancer antigen, such as expressed on a cancer cell, including cells infected with human papilloma virus (HPV) or that contain HPV DNA sequences and/or those that recognize or bind a peptide epitope of HPV 16 E6 or E7, in the context of a major histocompatibility complex (MHC) molecule. Among the provided binding molecules are T cell receptors (TCRs) or antibodies, including antigen-binding fragments thereof, that bind or recognize such peptide epitopes. The present disclosure further relates to engineered cells comprising such binding molecules, e.g., TCRs or antibodies (and chimeric antigen receptors containing the antibodies), and uses thereof in adoptive cell therapy.