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公开(公告)号：US20230181641A1
公开(公告)日：2023-06-15
申请号：US17924635
申请日：2021-05-12
发明人： Nathan YEE , Ryan LARSON , Calvin CHAN , Sara COOPER , Jeffrey TEOH , Daniel COSSETTE , Kohana LEUBA
IPC分类号： A61K35/17 , C12N5/0783 , C07K14/725 , C07K14/705 , C07K14/715 , A61K38/17 , A61P35/00
CPC分类号： A61K35/17 , C12N5/0636 , C07K14/7051 , C07K14/70521 , C07K14/7151 , A61K38/1774 , A61P35/00 , C12N2500/32 , C12N2501/2302 , C12N2501/2307 , C12N2501/2315 , C12N2501/515 , C12N2501/51
摘要： Provided herein are methods of producing engineered T cell compositions enriched for CD57 negative and/or CD27 positive T cells, such as from a plurality of donors. In some embodiments, the T cells are engineered with a recombinant receptor, such as a chimeric antigen receptor (CAR). Also provided herein are engineered T cell compositions containing T cells enriched for CD57 negative and/or CD27 positive T cells derived from a plurality of different donors, including compositions in which the T cells are engineered with or express a recombinant receptor (e.g. CAR). Also provided are methods of using the engineered T cell compositions in adoptive therapy, including in connection for cancer immunotherapy, such as for allogeneic therapies or for administration to one or more subjects in which the T cells are not derived from the subject(s) to whom the compositions are administered.
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公开(公告)号：US20210393691A1
公开(公告)日：2021-12-23
申请号：US17291536
申请日：2019-11-05
发明人： Sara COOPER , Daniel COSSETTE , Ryan LARSON , Jeffrey TEOH
摘要： The present disclosure provides cell populations enriched for CD57 negative T cells, or depleted for CD57 positive cells, and methods for stimulating, cultivating, expanding, and/or genetically engineering cell populations enriched for CD57− T cells or depleted for CD57+ T cells. Also included are methods for generating, isolating, enriching, or selecting CD57− T cells or depleting CD57+ cells, such as by negative selection.
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