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    Process for the preparation of alkylphosphocholines and the production thereof in pure form
    2.
    发明授权
    Process for the preparation of alkylphosphocholines and the production thereof in pure form 有权
    制备烷基磷酰胆碱的方法及其纯形式的制备

    公开(公告)号：US6028209A

    公开(公告)日：2000-02-22

    申请号：US296260

    申请日：1999-04-22

    申请人： Jurgen Engel ,  Bernd Kutscher ,  Wolfgang Schumacher ,  Ulf Niemeyer ,  Alfred Olbrich ,  Gerhard Nossner

    发明人： Jurgen Engel ,  Bernd Kutscher ,  Wolfgang Schumacher ,  Ulf Niemeyer ,  Alfred Olbrich ,  Gerhard Nossner

    IPC分类号： C07F9/02 ,  C07F9/09 ,  C07F9/10

    CPC分类号： C07F9/091 ,  C07F9/025

    摘要： A process for the preparation of C.sub.14 -C.sub.18 -alkylphosphocholines by reacting an n-alkanol with a chain length of C.sub.14 -C.sub.18 with phosphorus oxychloride in an inert solvent or also without solvent in the presence or absence of a basic substance in a single vessel process and subsequent reaction of the reaction product in an inert solvent with a choline salt in the presence of a basic substance to form phosphoric acid diester chloride, subsequent hydrolysis and isolation of alkylphosphocholine as well as optionally purification using a mixed-bed ion exchanger or in successive steps with an acid ion exchanger and a basic ion exchanger.

    摘要翻译： 通过在惰性溶剂中或在不存在碱性物质的情况下在惰性溶剂中或不存在溶剂的情况下使正链烷醇与C 3 -C 18烷基链与磷酰氯反应制备C14-C18-烷基磷酰胆碱的方法 随后在惰性溶剂中与胆碱盐在碱性物质存在下反应生成磷酸二酯，然后水解和分离烷基磷酸胆碱，以及任选地使用混合床离子交换剂进行纯化或连续 使用酸性离子交换剂和碱性离子交换剂。

    Salts of oxazaphosphorine derivatives
    4.
    发明授权
    Salts of oxazaphosphorine derivatives 失效
    恶唑烷衍生物的盐

    公开(公告)号：US4716242A

    公开(公告)日：1987-12-29

    申请号：US704465

    申请日：1985-02-22

    申请人： Jurgen Engel ,  Axel Kleemann ,  Ulf Niemeyer ,  Peter Hilgard ,  Joerg Pohl

    发明人： Jurgen Engel ,  Axel Kleemann ,  Ulf Niemeyer ,  Peter Hilgard ,  Joerg Pohl

    IPC分类号： C07F9/24 ,  A61K31/675 ,  A61P35/00 ,  A61P35/02 ,  C07F9/22 ,  C07F9/6584 ,  C07F9/40

    CPC分类号： C07F9/65846

    摘要： There are provided new antitumor salts of oxazaphosphorine derivatives of the formula ##STR1## where R.sub.1, R.sub.2, and R.sub.3 are the same or different and represent hydrogen, methyl, ethyl, 2-chloroethyl, or 2-methanesulfonyloxyethyl and wherein at least two of these residues are 2-chloroethyl and/or 2-methanesulfonyl-oxyethyl and A is the group --S--alk--SO.sub.3 H or --N(OH)--CONH--alk--CO.sub.2 H and alk represents a C.sub.2 -C.sub.6 -alkylene residue optionally containing a mercapto group, whereby alk also can be --CH.sub.2 -- in case there is a carboxy group attached to the alk group, with homocysteinethiolactone or .alpha.-amino-.epsilon.-caprolactam or a basic compound of the formula: ##STR2## wherein R.sub.4 is a hydroxy group, an amino group or a C.sub.1 -C.sub.6 -alkoxy group, R.sub.5 is hydrogen or a difluoromethyl group, R.sub.6 is hydrogen, an indolyl-(3)-methyl residue, imidazolyl-(4)-methyl residue, a C.sub.1 -C.sub.10 -alkyl group or a C.sub.1 -C.sub.10 -alkyl group which is substituted by a hydroxy group, a C.sub.1 -C.sub.6 -alkoxy group, a mercapto group, a C.sub.1 -C.sub.6 -alkylmercapto group, a phenyl group, a hydroxy phenyl group, an amino-C.sub.1 -C.sub.6 -alkylmercapto group, an amino-C.sub.1 -C.sub.6 -alkoxy group, an amino group, an aminocarbonyl group, a ureido group (H.sub.2 NCONH--), a guanidino group or a C.sub.1 -C.sub.6 -alkoxycarbonyl group, or wherein R.sub.6 together with the structured portion >CR.sub.5 (NR.sub.7 R.sub.8) forms the proline residue, the 4-hydroxy-proline residue or the 2-oxo-3-amino-3-difluoromethyl-piperidine and the residues R.sub.7 and R.sub.8 represent hydrogen or C.sub.1 -C.sub.6 -alkyl residues.

    摘要翻译： 提供了新的式（ⅩⅧ）的恶唑烷磷衍生物的抗肿瘤盐，其中R 1，R 2和R 3相同或不同，代表氢，甲基，乙基，2-氯乙基或2-甲磺酰氧基乙基，其中这些 残基是2-氯乙基和/或2-甲磺酰氧基乙基，A是-S-烷基-SO 3 H或-N（OH）-CONH-烷基-CO 2 H，烷基代表任选含有巯基的C 2 -C 6亚烷基 其中烷基也可以是-CH 2 - ，如果存在与烷基连接的羧基，具有同半胱氨酸硫内酯或α-氨基 - ε-己内酰胺或下式的碱性化合物：其中R 4是羟基 基团，氨基或C1-C6-烷氧基，R5是氢或二氟甲基，R6是氢，吲哚基 - （3） - 甲基残基，咪唑基 - （4） - 甲基残基，C1-C10- 烷基或被羟基，C1-C6-烷氧基，巯基，C1-C6烷基巯基取代的C1-C10-烷基 基团，苯基，羟基苯基，氨基-C 1 -C 6烷基巯基，氨基-C 1 -C 6烷氧基，氨基，氨基羰基，脲基（H 2 NCONH-），胍基 或C 1 -C 6烷氧基羰基，或其中R 6与结构部分> CR 5（NR 7 R 8）一起形成脯氨酸残基，4-羟基 - 脯氨酸残基或2-氧代-3-氨基-3-二氟甲基 - 哌啶和 残基R7和R8表示氢或C1-C6烷基残基。

    Method and circuit for regulating the signal level fed to an analog/digital converter
    6.
    发明授权
    Method and circuit for regulating the signal level fed to an analog/digital converter 有权
    用于调节馈送到模拟/数字转换器的信号电平的方法和电路

    公开(公告)号：US06690312B1

    公开(公告)日：2004-02-10

    申请号：US09959231

    申请日：2001-12-11

    申请人： Andreas Falkenberg ,  Ulf Niemeyer ,  Christoph Rohe

    发明人： Andreas Falkenberg ,  Ulf Niemeyer ,  Christoph Rohe

    IPC分类号： H03M166

    CPC分类号： H03M1/185

    摘要： For regulating the signal level fed to an analog/digital converter, the rate of change at which the output signal of the analog/digital converter changes over time, in particular the rate of change of an output bit of the analog/digital converter, is measured and compared with a setpoint value, in order to set the signal level fed to the analog/digital converter based on the comparison.

    摘要翻译： 为了调节馈送到模拟/数字转换器的信号电平，模拟/数字转换器的输出信号随时间变化的变化率，特别是模拟/数字转换器的输出位的变化率是 测量并与设定值进行比较，以便基于比较设置馈送到模拟/数字转换器的信号电平。

    Method for memory access control in rake receivers with early late tracking in telecommunication systems
    10.
    发明授权
    Method for memory access control in rake receivers with early late tracking in telecommunication systems 失效
    在电信系统中早期跟踪的耙式接收机中的存储器访问控制方法

    公开(公告)号：US07054351B1

    公开(公告)日：2006-05-30

    申请号：US09830624

    申请日：1999-10-27

    申请人： Reinhold Braam ,  Ulf Niemeyer ,  Oskar Skuk ,  Andreas Falkenberg ,  Christoph Rohe

    发明人： Reinhold Braam ,  Ulf Niemeyer ,  Oskar Skuk ,  Andreas Falkenberg ,  Christoph Rohe

    IPC分类号： H04B1/69

    CPC分类号： H04B1/7085 ,  H04B1/7117 ,  H04B1/712

    摘要： In order to control memory accesses in RAKE receivers having early-late tracking in telecommunications systems with wire-free telecommunication between mobile and/or stationary transmitters/receivers, in particular in third-generation mobile radio systems, such that the number of memory accesses is less than with previous known methods, data which is received in the RAKE receiver and is read by an early finger in the early-late tracking is buffer-stored and is passed on one read cycle later to a late finger for reading by the same in the early-late tracking.

    摘要翻译： 为了控制具有在移动和/或固定发射机/接收机之间的有线电信的电信系统中具有早期跟踪的RAKE接收机中的存储器访问，特别是在第三代移动无线电系统中，使得存储器访问的数量为 与先前已知的方法相比，在RAKE接收机中接收的并且在早期跟踪中由早期手指读取的数据被缓冲存储，并且在一个读取周期之后被传递到后期的手指以便读取它们 早期跟踪。