摘要:
The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.
摘要:
A roller block comprising a frame, a carriage vertically displaceable relative to the frame and having upwardly open or openable holders for the two ends of a roller unit which has a horizontal shaft or axis with at least one roller arranged thereon, and two bearers displaceable between a lowered position and a raised effective position, wherein the upper ends of the bearers form or are provided with bearing members for end members of the roller unit, which bearers are retainable in the raised position thereof independently of the carriage.
摘要:
The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.
摘要:
The present invention relates to a thermodynamically stable modification of the active compound ramatroban of formula (I). The thermodynamically stable form is prepared either by melting of the metastable form and subsequent recrystallization or by seeding a solution of the metastable active compound with a seed crystal of the thermodynamically stable form. The thermodynamically stable active compound can be employed as an asthma agent.
摘要:
The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.
摘要:
The present invention relates to a process for the preparation of sulphonamide-substituted imidazotriazinones of the general formula (I) characterized in that compounds of the formula (II) are reacted with sulphuric acid and the products obtained are then reacted with thionyl chloride and converted in situ in an inert solvent using an amine into the compounds according to the invention and, if appropriate, reacted to give the corresponding salts, hydrates or N-oxides.
摘要:
The invention relates to a process for the preparation of nifedipine by the reaction of methyl 2-(2-nitrobenzylidene)acetoacetate and methyl 3-aminocrotonate and the use of the nifedipine thus prepared for the production of a medicament.
摘要:
Apparatus for interchangeable mounting of rollers, comprising a roller unit having a shaft or axis with at least one roller arranged thereon and having two end members, a frame with a holder into which the roller unit is insertable from above, and lifter elements provided in or on the frame and by means of which the roller unit is displaceable between an operative position in which it is supported in the frame by supporting bearer members and a raised interchanged position in which it is removable from the frame.