公开(公告)号：US09204982B2

公开(公告)日：2015-12-08

申请号：US13457418

申请日：2012-04-26

申请人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joe Traina ,  Rajen Kumar

发明人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joe Traina ,  Rajen Kumar

IPC分类号： A61F2/82 ,  A61F2/915 ,  A61L31/16

CPC分类号： A61F2/82 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0035 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2300/416 ,  B05B13/06

摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

摘要翻译： 公开了用于在形成支架的中空丝内填充治疗物质或药物的方法和装置。 将支架放置在容纳流体药物制剂的腔室内。 在填充期间，室被保持在或接近流体药物制剂的溶剂的气液平衡。 为了填充支架，将支架的一部分放置成与流体药物制剂接触，直到由空心线限定的腔空间通过毛细作用填充流体药物制剂。 填充完成后，支架缩回，使得支架不再与流体药物制剂接触。 室内的溶剂蒸气压降低以蒸发流体药物制剂的溶剂。 芯吸装置可以控制流体药物制剂转移到支架中。

公开(公告)号：US20130284311A1

公开(公告)日：2013-10-31

申请号：US13457418

申请日：2012-04-26

申请人： Justin PETERSON ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Jose Traina ,  Rajen Kumar

发明人： Justin PETERSON ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Jose Traina ,  Rajen Kumar

IPC分类号： B65B3/04

CPC分类号： A61F2/82 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0035 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2300/416 ,  B05B13/06

摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

公开(公告)号：US09549832B2

公开(公告)日：2017-01-24

申请号：US13457398

申请日：2012-04-26

申请人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

发明人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

IPC分类号： A61F2/91 ,  A61L31/16

CPC分类号： A61F2/91 ,  A61F2/82 ,  A61F2240/00 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2420/02

摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

摘要翻译： 公开了用于在形成支架的中空丝内填充治疗物质或药物的方法和装置。 将支架放置在容纳流体药物制剂的腔室内。 在填充期间，室被保持在或接近流体药物制剂的溶剂的气液平衡。 为了填充支架，将支架的一部分放置成与流体药物制剂接触，直到由空心线限定的腔空间通过毛细作用填充流体药物制剂。 填充完成后，支架缩回，使得支架不再与流体药物制剂接触。 室内的溶剂蒸气压降低以蒸发流体药物制剂的溶剂。 芯吸装置可以控制流体药物制剂转移到支架中。

公开(公告)号：US20130284310A1

公开(公告)日：2013-10-31

申请号：US13457398

申请日：2012-04-26

申请人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

发明人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

IPC分类号： B65B1/04

CPC分类号： A61F2/91 ,  A61F2/82 ,  A61F2240/00 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2420/02

摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

摘要翻译： 公开了用于在形成支架的中空丝内填充治疗物质或药物的方法和装置。 将支架放置在容纳流体药物制剂的腔室内。 在填充期间，室被保持在或接近流体药物制剂的溶剂的气液平衡。 为了填充支架，将支架的一部分放置成与流体药物制剂接触，直到由空心线限定的腔空间通过毛细作用填充流体药物制剂。 填充完成后，支架缩回，使得支架不再与流体药物制剂接触。 室内的溶剂蒸气压降低以蒸发流体药物制剂的溶剂。 芯吸装置可以控制流体药物制剂转移到支架中。