公开(公告)号：US09549832B2

公开(公告)日：2017-01-24

申请号：US13457398

申请日：2012-04-26

申请人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

发明人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

IPC分类号： A61F2/91 ,  A61L31/16

CPC分类号： A61F2/91 ,  A61F2/82 ,  A61F2240/00 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2420/02

摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

摘要翻译： 公开了用于在形成支架的中空丝内填充治疗物质或药物的方法和装置。 将支架放置在容纳流体药物制剂的腔室内。 在填充期间，室被保持在或接近流体药物制剂的溶剂的气液平衡。 为了填充支架，将支架的一部分放置成与流体药物制剂接触，直到由空心线限定的腔空间通过毛细作用填充流体药物制剂。 填充完成后，支架缩回，使得支架不再与流体药物制剂接触。 室内的溶剂蒸气压降低以蒸发流体药物制剂的溶剂。 芯吸装置可以控制流体药物制剂转移到支架中。

公开(公告)号：US08460238B2

公开(公告)日：2013-06-11

申请号：US12728860

申请日：2010-03-22

申请人： Peiwen Cheng ,  Justin Peterson

发明人： Peiwen Cheng ,  Justin Peterson

IPC分类号： A61M31/00

CPC分类号： A61M25/10 ,  A61L29/085 ,  A61L29/146 ,  A61L29/16 ,  A61L2300/622 ,  A61M2025/105

摘要： A drug delivery catheter and method for delivering microcapsules or microspheres containing a drug, pharmacological or other bioactive agent includes a balloon catheter having a coating on the balloon of a soluble biocompatible polymer containing a plurality of microcapsules or microspheres containing a drug or other agent. The balloon is porous to allow it to be inflated with a solvent fluid that passes through the porous wall of the balloon and dissolves the polymer, releasing the microspheres.

摘要翻译： 用于递送包含药物，药理学或其它生物活性剂的微胶囊或微球的药物递送导管和方法包括球囊导管，其在球囊上具有包含多个含有药物或其它药剂的微胶囊或微球的可溶性生物相容性聚合物的涂层。 气球是多孔的，以允许其通过溶剂流体膨胀，溶剂流体通过球囊的多孔壁并溶解聚合物，释放微球体。

公开(公告)号：US09204982B2

公开(公告)日：2015-12-08

申请号：US13457418

申请日：2012-04-26

申请人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joe Traina ,  Rajen Kumar

发明人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joe Traina ,  Rajen Kumar

IPC分类号： A61F2/82 ,  A61F2/915 ,  A61L31/16

CPC分类号： A61F2/82 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0035 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2300/416 ,  B05B13/06

摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

摘要翻译： 公开了用于在形成支架的中空丝内填充治疗物质或药物的方法和装置。 将支架放置在容纳流体药物制剂的腔室内。 在填充期间，室被保持在或接近流体药物制剂的溶剂的气液平衡。 为了填充支架，将支架的一部分放置成与流体药物制剂接触，直到由空心线限定的腔空间通过毛细作用填充流体药物制剂。 填充完成后，支架缩回，使得支架不再与流体药物制剂接触。 室内的溶剂蒸气压降低以蒸发流体药物制剂的溶剂。 芯吸装置可以控制流体药物制剂转移到支架中。

公开(公告)号：US20100268191A1

公开(公告)日：2010-10-21

申请号：US12427177

申请日：2009-04-21

申请人： Julie Trudel ,  Justin Peterson

发明人： Julie Trudel ,  Justin Peterson

IPC分类号： A61M25/10 ,  A61K9/50

CPC分类号： A61K9/5005 ,  A61M25/10 ,  A61M2025/105

摘要： A drug delivery catheter and method are provided for delivering drugs to a targeted region of a lumen include drug-laden microcapsules provided within a porous catheter balloon with an effective pore size that prevents free-flow of the microcapsules through the porous wall of the balloon. The microcapsules are frangible under the influence of increased pressure within the balloon. In an alternative embodiment, the microcapsules may be mechanically ruptured by compression between the outer porous balloon and optional, inner, non-porous balloon. The drug is emitted from the microcapsules through the balloon pores and against the targeted luminal surface.

摘要翻译： 提供用于将药物输送到腔的目标区域的药物递送导管和方法包括设置在多孔导管球囊内的药物载体微胶囊，其具有有效孔径，其防止微胶囊通过气囊的多孔壁自由流动。 在气囊内压力增加的影响下，微胶囊是易碎的。 在另一个实施方案中，微胶囊可以通过外部多孔气囊和任选的内部无孔球囊之间的压缩机械破裂。 药物从微胶囊通过球囊孔排出并抵靠靶向的腔表面。

公开(公告)号：US08828474B2

公开(公告)日：2014-09-09

申请号：US12884596

申请日：2010-09-17

申请人： James E. Mitchell ,  William Heaton ,  Dishuan Chu ,  Terry Morgan ,  Justin Peterson ,  Joseph Traina

发明人： James E. Mitchell ,  William Heaton ,  Dishuan Chu ,  Terry Morgan ,  Justin Peterson ,  Joseph Traina

IPC分类号： B05D3/00 ,  A61K9/28 ,  A61L33/00

CPC分类号： A61L31/16 ,  A61F2240/001 ,  A61F2250/0068 ,  A61L2300/416

摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

公开(公告)号：US08381774B2

公开(公告)日：2013-02-26

申请号：US12884362

申请日：2010-09-17

申请人： James Mitchell ,  Dishuan Chu ,  Justin Peterson ,  Joseph Traina

发明人： James Mitchell ,  Dishuan Chu ,  Justin Peterson ,  Joseph Traina

IPC分类号： B65B1/04 ,  B05D7/22

CPC分类号： A61L31/16 ,  A61F2240/001 ,  A61F2250/0068

摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。

公开(公告)号：US20110070357A1

公开(公告)日：2011-03-24

申请号：US12884503

申请日：2010-09-17

申请人： James E. Mitchell ,  Justin Peterson ,  Dishuan Chu ,  Joseph Traina ,  Salvador Avelar ,  Michele Silver

发明人： James E. Mitchell ,  Justin Peterson ,  Dishuan Chu ,  Joseph Traina ,  Salvador Avelar ,  Michele Silver

IPC分类号： B05D7/00

CPC分类号： A61L31/16 ,  A61F2240/001 ,  A61F2250/0068

摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。

公开(公告)号：US20110067778A1

公开(公告)日：2011-03-24

申请号：US12884362

申请日：2010-09-17

申请人： James E. Mitchell ,  Dishuan Chu ,  Justin Peterson ,  Joseph Traina

发明人： James E. Mitchell ,  Dishuan Chu ,  Justin Peterson ,  Joseph Traina

IPC分类号： B65B1/04

CPC分类号： A61L31/16 ,  A61F2240/001 ,  A61F2250/0068

摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

公开(公告)号：US20120070563A1

公开(公告)日：2012-03-22

申请号：US12884596

申请日：2010-09-17

申请人： James E. Mitchell ,  William Heaton ,  Dishuan Chu ,  Terry Morgan ,  Justin Peterson ,  Joseph Traina

发明人： James E. Mitchell ,  William Heaton ,  Dishuan Chu ,  Terry Morgan ,  Justin Peterson ,  Joseph Traina

IPC分类号： B05D3/02 ,  B05D3/10

CPC分类号： A61L31/16 ,  A61F2240/001 ,  A61F2250/0068 ,  A61L2300/416

摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。

公开(公告)号：US09326870B2

公开(公告)日：2016-05-03

申请号：US12766480

申请日：2010-04-23

申请人： Joseph Berglund ,  Justin Peterson

发明人： Joseph Berglund ,  Justin Peterson

IPC分类号： A61F2/06 ,  A61F2/86 ,  A61F2/07 ,  A61F2/852 ,  A61F2/90 ,  A61F2/82 ,  A61F2/848

CPC分类号： A61F2/86 ,  A61F2/07 ,  A61F2/852 ,  A61F2/90 ,  A61F2002/825 ,  A61F2002/8483 ,  A61F2210/0004 ,  A61F2220/0016 ,  A61F2230/0054 ,  A61F2250/0031 ,  A61F2250/0063

摘要： A hybrid stent prosthesis including a biodegradable tubular body, a first non-biodegradable self-expanding ring coupled to a proximal end of the biodegradable body, and a second non-biodegradable self-expanding ring coupled to a distal end of the biodegradable body. The hybrid stent includes a mechanism for longitudinally compressing the tubular body to increase the radial or hoop strength thereof. The longitudinally compressing mechanism may be protruding elements coupled to and extending radially outward from the hybrid stent or elastomeric compression bands or tethers extending between the non-biodegradable rings. The compression bands may be pre-connected to both non-biodegradable rings prior to stent delivery, or may be connected to one non-biodegradable ring prior to insertion and connected to the other non-biodegradable ring in situ.

摘要翻译： 一种混合支架假体，包括可生物降解的管状体，联接到生物可降解体的近端的第一不可生物降解的自膨胀环，以及联接到可生物降解的身体的远端的第二不可生物降解的自膨胀环。 混合支架包括用于纵向压缩管状体以增加其径向或环向强度的机构。 纵向压缩机构可以是从混合支架或弹性体压缩带或在不可生物降解的环之间延伸的系绳的径向向外的突出元件。 在支架输送之前，压缩带可以预先连接到不可生物降解的环上，或者可以在插入之前连接到一个不可生物降解的环，并且原位连接到另一个不可生物降解的环。