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    Apparatus and methods for filling a drug eluting medical device via capillary action
    2.
    发明授权
    Apparatus and methods for filling a drug eluting medical device via capillary action 有权
    用于通过毛细作用填充药物洗脱医疗装置的装置和方法

    公开(公告)号：US09204982B2

    公开(公告)日：2015-12-08

    申请号：US13457418

    申请日：2012-04-26

    申请人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joe Traina ,  Rajen Kumar

    发明人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joe Traina ,  Rajen Kumar

    IPC分类号： A61F2/82 ,  A61F2/915 ,  A61L31/16

    CPC分类号： A61F2/82 ,  A61F2/915 ,  A61F2002/91541 ,  A61F2002/91575 ,  A61F2230/0054 ,  A61F2240/001 ,  A61F2250/0035 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2300/416 ,  B05B13/06

    摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

    摘要翻译： 公开了用于在形成支架的中空丝内填充治疗物质或药物的方法和装置。 将支架放置在容纳流体药物制剂的腔室内。 在填充期间，室被保持在或接近流体药物制剂的溶剂的气液平衡。 为了填充支架，将支架的一部分放置成与流体药物制剂接触，直到由空心线限定的腔空间通过毛细作用填充流体药物制剂。 填充完成后，支架缩回，使得支架不再与流体药物制剂接触。 室内的溶剂蒸气压降低以蒸发流体药物制剂的溶剂。 芯吸装置可以控制流体药物制剂转移到支架中。

    Apparatus and methods for filling a drug eluting medical device via capillary action
    3.
    发明授权
    Apparatus and methods for filling a drug eluting medical device via capillary action 有权
    用于通过毛细作用填充药物洗脱医疗装置的装置和方法

    公开(公告)号：US09549832B2

    公开(公告)日：2017-01-24

    申请号：US13457398

    申请日：2012-04-26

    申请人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

    发明人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

    IPC分类号： A61F2/91 ,  A61L31/16

    CPC分类号： A61F2/91 ,  A61F2/82 ,  A61F2240/00 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2420/02

    摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

    摘要翻译： 公开了用于在形成支架的中空丝内填充治疗物质或药物的方法和装置。 将支架放置在容纳流体药物制剂的腔室内。 在填充期间，室被保持在或接近流体药物制剂的溶剂的气液平衡。 为了填充支架，将支架的一部分放置成与流体药物制剂接触，直到由空心线限定的腔空间通过毛细作用填充流体药物制剂。 填充完成后，支架缩回，使得支架不再与流体药物制剂接触。 室内的溶剂蒸气压降低以蒸发流体药物制剂的溶剂。 芯吸装置可以控制流体药物制剂转移到支架中。

    APPARATUS AND METHODS FOR FILLING A DRUG ELUTING MEDICAL DEVICE VIA CAPILLARY ACTION
    4.
    发明申请
    APPARATUS AND METHODS FOR FILLING A DRUG ELUTING MEDICAL DEVICE VIA CAPILLARY ACTION 有权
    用于通过毛细管动作填充药物治疗医疗装置的装置和方法

    公开(公告)号：US20130284310A1

    公开(公告)日：2013-10-31

    申请号：US13457398

    申请日：2012-04-26

    申请人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

    发明人： Justin Peterson ,  James Mitchell ,  Abby Schlichting ,  Nate Glucklich ,  Joseph Berglund ,  Ya Guo

    IPC分类号： B65B1/04

    CPC分类号： A61F2/91 ,  A61F2/82 ,  A61F2240/00 ,  A61F2250/0068 ,  A61L31/16 ,  A61L2420/02

    摘要： Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

    摘要翻译： 公开了用于在形成支架的中空丝内填充治疗物质或药物的方法和装置。 将支架放置在容纳流体药物制剂的腔室内。 在填充期间，室被保持在或接近流体药物制剂的溶剂的气液平衡。 为了填充支架，将支架的一部分放置成与流体药物制剂接触，直到由空心线限定的腔空间通过毛细作用填充流体药物制剂。 填充完成后，支架缩回，使得支架不再与流体药物制剂接触。 室内的溶剂蒸气压降低以蒸发流体药物制剂的溶剂。 芯吸装置可以控制流体药物制剂转移到支架中。

    Methods for loading a drug eluting medical device
    5.
    发明授权
    Methods for loading a drug eluting medical device 有权
    载药药物洗脱医疗器械的方法

    公开(公告)号：US08381774B2

    公开(公告)日：2013-02-26

    申请号：US12884362

    申请日：2010-09-17

    申请人： James Mitchell ,  Dishuan Chu ,  Justin Peterson ,  Joseph Traina

    发明人： James Mitchell ,  Dishuan Chu ,  Justin Peterson ,  Joseph Traina

    IPC分类号： B65B1/04 ,  B05D7/22

    CPC分类号： A61L31/16 ,  A61F2240/001 ,  A61F2250/0068

    摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

    摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。

    Apparatus and methods for loading a drug eluting medical device
    6.
    发明授权
    Apparatus and methods for loading a drug eluting medical device 有权
    用于装载药物洗脱医疗装置的装置和方法

    公开(公告)号：US08460745B2

    公开(公告)日：2013-06-11

    申请号：US12884503

    申请日：2010-09-17

    申请人： James Mitchell ,  Justin Peterson ,  Dishuan Chu ,  Joseph Traina ,  Salvador Avelar ,  Michele Silver

    发明人： James Mitchell ,  Justin Peterson ,  Dishuan Chu ,  Joseph Traina ,  Salvador Avelar ,  Michele Silver

    IPC分类号： B05D7/22 ,  B05D1/18 ,  A61F2/06 ,  B65B31/02 ,  A61L33/00

    CPC分类号： A61L31/16 ,  A61F2240/001 ,  A61F2250/0068

    摘要： Methods and apparatus are disclosed for loading a therapeutic substance or drug within a lumenal space of a hollow wire having a plurality of side openings along a length thereof that forms a hollow drug-eluting stent with a plurality of side drug delivery openings. Loading a drug within the lumenal space of the hollow stent includes a drug filling step, in which the drug is mixed with a solvent or dispersion medium. The lumenal space may be filled with the drug solution or suspension in a reverse fill process and/or a forward fill process. After the drug filling step, a solvent or dispersion medium extracting step is performed to extract the solvent or dispersion medium from within the lumenal space such that only the drug remains within the hollow stent. A stent cleaning step may be performed to an exterior surface of the hollow stent.

    摘要翻译： 公开的方法和装置用于将治疗物质或药物装载在具有沿其长度的多个侧开口的中空丝的内腔空间内，所述多个侧开口形成具有多个侧药物输送开口的中空药物洗脱支架。 在中空支架的内腔空间内装载药物包括药物填充步骤，其中药物与溶剂或分散介质混合。 可以在反向填充过程和/或正向填充过程中用药物溶液或悬浮液填充管腔空间。 在药物填充步骤之后，进行溶剂或分散介质提取步骤，以从内腔空间中提取溶剂或分散介质，使得只有药物保留在中空支架内。 可以对中空支架的外表面执行支架清洁步骤。

    Hollow drug-filled stent and method of forming hollow drug-filled stent
    8.
    发明授权
    Hollow drug-filled stent and method of forming hollow drug-filled stent 有权
    空心药物填充支架和形成中空药物填充支架的方法

    公开(公告)号：US08998977B2

    公开(公告)日：2015-04-07

    申请号：US13447004

    申请日：2012-04-13

    申请人： Ryan Bienvenu ,  James Mitchell ,  Dustin Thompson

    发明人： Ryan Bienvenu ,  James Mitchell ,  Dustin Thompson

    IPC分类号： A61F2/06 ,  B21D3/00 ,  B21D17/02 ,  A61F2/86 ,  A61F2/91 ,  A61L31/02 ,  A61L31/16 ,  A61L31/18

    CPC分类号： A61F2/86 ,  A61F2/91 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0068 ,  A61F2250/0098 ,  A61L31/022 ,  A61L31/16 ,  A61L31/18 ,  Y10T29/49817 ,  Y10T29/4998

    摘要： A stent is formed from a wire having an outer member, a radiopaque member lining at least a portion of the outer member inner surface, and a lumen defined by the outer member inner surface or the radiopaque member inner surface. A substance is disposed in the lumen to be eluted through at least one opening disposed through the outer member to the lumen. The radiopaque member may be substantially continuous along the length of the wire or disposed only along portions of the wire such as crowns. In a method for making the stent, a composite wire including an outer member, a radiopaque intermediate member, and a core member is shaped into a stent pattern and processed to remove the core member and optionally portions of the radiopaque intermediate member, without damaging the outer member.

    摘要翻译： 支架由具有外部构件的线材，内部至少部分外部构件内表面的不透射线构件以及由外部构件内表面或不透射线构件内表面限定的内腔形成。 物质被设置在内腔中以通过穿过外部构件设置到内腔的至少一个开口被洗脱。 不透射线的构件可以沿着导线的长度基本上是连续的，或者仅沿着线的部分如冠冠设置。 在制造支架的方法中，将包括外部构件，不透射线中间构件和芯构件的复合线材成形为支架图案并且被处理以移除芯构件以及可选地部分不透射线的中间构件，而不损坏 外部成员。

    Systems and methods for automatic discovery of systems and accounts
    9.
    发明授权
    Systems and methods for automatic discovery of systems and accounts 有权
    自动发现系统和帐户的系统和方法

    公开(公告)号：US08863253B2

    公开(公告)日：2014-10-14

    申请号：US12571231

    申请日：2009-09-30

    申请人： Gyle Iverson ,  Jeffery Nielsen ,  Julie Lustig-Rusch ,  James Mitchell

    发明人： Gyle Iverson ,  Jeffery Nielsen ,  Julie Lustig-Rusch ,  James Mitchell

    IPC分类号： H04L29/06

    CPC分类号： H04L63/102 ,  H04L63/083 ,  H04L63/10 ,  H04L63/1433

    摘要： In various embodiments, a method comprises scanning a directory structure to generate a scan result comprising a plurality of discovered systems, identifying one or more accounts associated with at least one of the plurality of discovered systems, configuring a security appliance to change one or more old passwords to one or more new passwords for the one or more accounts, and changing, with the configured security appliance, the one or more old passwords to the one or more new passwords.

    摘要翻译： 在各种实施例中，一种方法包括扫描目录结构以生成包括多个发现的系统的扫描结果，识别与所述多个发现的系统中的至少一个相关联的一个或多个帐户，配置安全设备以改变一个或多个旧的 一个或多个帐户的一个或多个新密码的密码，以及使用已配置的安全设备将一个或多个旧密码更改为一个或多个新密码。