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1.发明申请公开(公告)号：US20130017200A1
公开(公告)日：2013-01-17
申请号：US13510145
申请日：2010-12-03
申请人： Justin Scheer , Richard L. Vandlen
发明人： Justin Scheer , Richard L. Vandlen
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/283 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/55 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/90
摘要： Multispecific antibodies that specifically bind at least two different epitopes are provided. Structural variants of native antibodies (antibody analogs) are also provided. Also provided are multispecific antibodies and antibody analogs having a range of biological activities. Agonist and antagonist multispecific antibodies and agonist and antagonist antibody analogs are provided. Multispecific antibodies and antibody analogs conjugated with therapeutic and/or diagnostic agents are also provided, as are multispecific antibodies and antibody analogs conjugated with agents to increase in vivo half-life compared to multispecific antibodies and antibody analogs lacking such agents. In addition, methods of making multispecific antibodies and antibody analogs and compositions comprising multispecific antibodies and antibody analogs are provided. Therapeutic, research, and diagnostic uses of multispecific antibodies and antibody analogs are also provided.
摘要翻译： 提供特异性结合至少两个不同表位的多特异性抗体。 还提供天然抗体（抗体类似物）的结构变体。 还提供了具有一系列生物活性的多特异性抗体和抗体类似物。 提供激动剂和拮抗剂多特异性抗体和激动剂和拮抗剂抗体类似物。 还提供与治疗和/或诊断试剂缀合的多特异性抗体和抗体类似物，多特异性抗体和与试剂结合的抗体类似物与缺乏这种试剂的多特异性抗体和抗体类似物相比增加体内半衰期。 此外，提供制备多特异性抗体和抗体类似物的方法以及包含多特异性抗体和抗体类似物的组合物。 还提供了多特异性抗体和抗体类似物的治疗，研究和诊断用途。
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公开(公告)号：US10584181B2
公开(公告)日：2020-03-10
申请号：US13510145
申请日：2010-12-03
申请人： Justin Scheer , Richard L. Vandlen
发明人： Justin Scheer , Richard L. Vandlen
摘要： Multispecific antibodies that specifically bind at least two different epitopes are provided. Structural variants of native antibodies (antibody analogs) are also provided. Also provided are multispecific antibodies and antibody analogs having a range of biological activities. Agonist and antagonist multispecific antibodies and agonist and antagonist antibody analogs are provided. Multispecific antibodies and antibody analogs conjugated with therapeutic and/or diagnostic agents are also provided, as are multispecific antibodies and antibody analogs conjugated with agents to increase in vivo half-life compared to multispecific antibodies and antibody analogs lacking such agents. In addition, methods of making multispecific antibodies and antibody analogs and compositions comprising multispecific antibodies and antibody analogs are provided. Therapeutic, research, and diagnostic uses of multispecific antibodies and antibody analogs are also provided.
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公开(公告)号：US20110287938A1
公开(公告)日：2011-11-24
申请号：US13196755
申请日：2011-08-02
申请人： Barbara Scheer , Justin Scheer
发明人： Barbara Scheer , Justin Scheer
摘要： Methods for reducing leaf senescence in plants or portions thereof by treating them with methyl dihydrojasmonate are disclosed. The methyl dihydrojasmonate may be in the form of an aqueous foliar spray, which may also include additives such as wetting agents, adjuvants, emulsifiers, dispersants, spreaders, surfactants, anchorage, disintegrants, and plant nutrients.
摘要翻译： 公开了通过用二氢茉尔酮酸甲酯处理它们来减少植物或其部分中叶片衰老的方法。 二氢茉莉酮酸甲酯可以是叶面喷雾剂的形式，其还可以包括添加剂，例如润湿剂，助剂，乳化剂，分散剂，撒布剂，表面活性剂，锚定剂，崩解剂和植物营养素。
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公开(公告)号：US20090282588A1
公开(公告)日：2009-11-12
申请号：US12424790
申请日：2009-04-16
申请人： Barbara Scheer , Justin Scheer
发明人： Barbara Scheer , Justin Scheer
CPC分类号： A01N37/42
摘要： Methods for reducing leaf senescence in plants or portions thereof by treating them with methyl dihydrojasmonate are disclosed. The methyl dihydrojasmonate may be in the form of an aqueous foliar spray, which may also include additives such as wetting agents, adjuvants, emulsifiers, dispersants, spreaders, surfactants, anchorage, disintegrants, and plant nutrients.
摘要翻译： 公开了通过用二氢茉尔酮酸甲酯处理它们来减少植物或其部分中叶片衰老的方法。 二氢茉莉酮酸甲酯可以是叶面喷雾剂的形式，其还可以包括添加剂，例如润湿剂，助剂，乳化剂，分散剂，撒布剂，表面活性剂，锚定剂，崩解剂和植物营养素。
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5.发明申请Methods for Improving Flowering Characteristics Using Methyl Dihydrojasmonate 审中-公开使用甲基二氢茉莉酮酸改善开花特征的方法公开(公告)号：US20090133166A1
公开(公告)日：2009-05-21
申请号：US12272060
申请日：2008-11-17
申请人： Barbara Scheer , Justin Scheer
发明人： Barbara Scheer , Justin Scheer
摘要： Methods and formulations for improving the flowering characteristics of plants, such as rose plants, are disclosed. The formulations include methyl dihydrojasmonate: Methods and formulations according to embodiments of the invention may increase the duration that cut flowers last, increase the degree to which buds open to full flower, and increase the turgidity of stems. They may also prolong flower opening on intact flowering plants.
摘要翻译： 公开了用于改善植物如玫瑰植物的开花特征的方法和制剂。 制剂包括二氢茉莉酮酸甲酯：根据本发明实施方案的方法和制剂可以增加切花最后的持续时间，增加芽对全花开放的程度，并增加茎的潮湿。 它们还可以在完整的开花植物上延长开花。
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公开(公告)号：US20110287009A1
公开(公告)日：2011-11-24
申请号：US13092708
申请日：2011-04-22
IPC分类号： A61K39/395 , C40B50/06 , C07K1/22 , C12P21/00 , C07K1/14
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/244 , C07K16/247 , C07K16/2863 , C07K16/30 , C07K2317/31 , C07K2317/526 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , Y02A50/41
摘要： Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
摘要翻译： 本文描述了有效制备能够特异性结合多于一种靶的抗体和其它多聚体蛋白复合物（统称为异多聚体蛋白质）的方法。 靶可以是例如在单个分子上或位于不同分子上的不同表位。 该方法结合了有效，高基因表达水平，合适的组装和异源多聚体蛋白的纯化方便。 本发明还提供了使用这些异源多聚体蛋白质的方法，以及包含这些抗体的组合物，试剂盒和制品。
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公开(公告)号：US08013226B2
公开(公告)日：2011-09-06
申请号：US12424790
申请日：2009-04-16
申请人： Barbara Scheer , Justin Scheer
发明人： Barbara Scheer , Justin Scheer
IPC分类号： A01H5/00
CPC分类号： A01N37/42
摘要： Methods for reducing leaf senescence in plants or portions thereof by treating them with methyl dihydrojasmonate are disclosed. The methyl dihydrojasmonate may be in the form of an aqueous foliar spray, which may also include additives such as wetting agents, adjuvants, emulsifiers, dispersants, spreaders, surfactants, anchorage, disintegrants, and plant nutrients.
摘要翻译： 公开了通过用二氢茉尔酮酸甲酯处理它们来减少植物或其部分中叶片衰老的方法。 二氢茉莉酮酸甲酯可以是叶面喷雾剂的形式，其还可以包括添加剂，例如润湿剂，助剂，乳化剂，分散剂，撒布剂，表面活性剂，锚定剂，崩解剂和植物营养素。
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公开(公告)号：US09637557B2
公开(公告)日：2017-05-02
申请号：US13092708
申请日：2011-04-22
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/244 , C07K16/247 , C07K16/2863 , C07K16/30 , C07K2317/31 , C07K2317/526 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , Y02A50/41
摘要： Described herein are methods for the efficient production of antibodies and other multimeric protein complexes (collectively referred to herein as heteromultimeric proteins) capable of specifically binding to more than one target. The targets may be, for example, different epitopes on a single molecule or located on different molecules. The methods combine efficient, high gene expression level, appropriate assembly, and ease of purification for the heteromultimeric proteins. The invention also provides methods of using these heteromultimeric proteins, and compositions, kits and articles of manufacture comprising these antibodies.
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公开(公告)号：US08563839B2
公开(公告)日：2013-10-22
申请号：US13196755
申请日：2011-08-02
申请人： Barbara Scheer , Justin Scheer
发明人： Barbara Scheer , Justin Scheer
IPC分类号： A01H5/00
摘要： Methods for reducing leaf senescence in plants or plant portions by treating them with methyl dihydrojasmonate are disclosed. The methyl dihydrojasmonate may be in the form of an aqueous foliar spray, which may also include additives such as wetting agents, adjuvants, emulsifiers, dispersants, spreaders, surfactants, anchorage, disintegrants, and plant nutrients.
摘要翻译： 公开了通过用二氢茉尔酮酸甲酯处理来减少植物或植物部分叶片衰老的方法。 二氢茉莉酮酸甲酯可以是叶面喷雾剂的形式，其还可以包括添加剂，例如润湿剂，助剂，乳化剂，分散剂，撒布剂，表面活性剂，锚定剂，崩解剂和植物营养素。
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10.发明申请Exogenous Methyl Dihydrojasmonate for Prevention and Control of Biotic Attack in Plants 审中-公开外源甲基二氢茉莉酮酸酯预防和控制植物生物攻击公开(公告)号：US20090082453A1
公开(公告)日：2009-03-26
申请号：US12235654
申请日：2008-09-23
申请人： Barbara Scheer , Justin Scheer
发明人： Barbara Scheer , Justin Scheer
CPC分类号： A01N37/42
摘要： Formulations and methods for treating and preventing biotic attack, including disease and insect infestation, in plants are disclosed. The formulations include methyl dihydrojasmonate: Formulations according to embodiments of the invention are particularly suitable for controlling insect infestation and disease in roses.
摘要翻译： 公开了在植物中治疗和预防生物攻击（包括疾病和昆虫侵袭）的制剂和方法。 制剂包括二氢茉莉酮酸甲酯：根据本发明实施方案的制剂特别适用于控制玫瑰中的昆虫侵袭和疾病。
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