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公开(公告)号：US10980416B2
公开(公告)日：2021-04-20
申请号：US15531842
申请日：2015-11-02
发明人： Akitoshi Yoshida , Masahiro Akiba
摘要： A blood flow measurement apparatus of an embodiment includes an image acquisition unit, an image region specification unit, a measurement location setting unit, a scanner, and a blood flow information generation unit. The image acquisition unit acquires an image of a living body. The image region specification unit analyzes the image to specify a plurality of blood vessel regions. The measurement location setting unit sets a plurality of measurement locations that intersects with the plurality of blood vessel regions. The scanner scans a plurality of cross sections of the living body corresponding to the plurality of measurement locations using optical coherence tomography. The blood flow information generation unit generates blood flow information on the living body based on data acquired through the scan.
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公开(公告)号：US09717408B2
公开(公告)日：2017-08-01
申请号：US14655440
申请日：2013-12-04
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/09 , A61B3/1173 , A61B3/12 , A61B3/14
摘要： An ophthalmologic imaging apparatus includes: a first optical system that applies an accommodation stimulus to a subject's eye; a tomographic image forming unit that includes a second optical system that splits light from a light source into signal light and reference light, and detects interference light between the signal light having travelled via the subject's eye and the reference light, and creates a tomographic image of the subject's eye based on a detection result of the interference light; and an analyzer that compares a first tomographic image with a second tomographic image to acquire change information indicating a change in a tissue of the subject's eye due to an accommodation stimulus change. The first and second tomographic images are respectively created by the tomographic image forming unit for the subject's eye, to which first and second accommodation stimuli are respectively applied by the first and second optical systems.
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公开(公告)号：US10478058B2
公开(公告)日：2019-11-19
申请号：US15528080
申请日：2015-11-19
发明人： Jun Cheng , Jiang Liu , Wing Kee Damon Wong , Masahiro Akiba
摘要： An optical coherence tomography (OCT) image composed of a plurality of A-scans of a structure is analyzed by defining, for each A-scan, a set of neighboring A-scans surrounding the A-slices scan. Following an optional de-noising step, the neighboring A-scans are aligned in the imaging direction, then a matrix X is formed from the aligned A-scans, and matrix completion is performed to obtain a reduced speckle noise image.
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公开(公告)号：US20180055352A1
公开(公告)日：2018-03-01
申请号：US15791700
申请日：2017-10-24
CPC分类号： A61B3/102 , A61B3/0008 , A61B3/1025 , A61B3/13 , A61B3/14 , A61B3/15 , A61B90/30 , A61F9/007 , G02B15/14 , G02B27/141
摘要： An ophthalmic surgical apparatus includes an observation optical system, an illumination optical system, an interference optical system, and an image forming unit. The observation optical system is configured to observe an eye through an objective lens. The illumination optical system is configured to illuminate the eye through the objective lens. The interference optical system includes a reference optical path and a signal optical path which leads to the eye through the deflecting member located between the objective lens and the eye, and is configured to detect interference light based on light having passed through the signal optical path and returning from the eye and the reference light having passed through the reference optical path. The image forming unit forms an image of the eye based on a detection result obtained by the interference optical system.
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公开(公告)号：US10426335B2
公开(公告)日：2019-10-01
申请号：US15565542
申请日：2016-01-21
发明人： Masahiro Akiba , Atsushi Kubota
摘要： An ophthalmic image display device having, a display controller that displays a B mode image, a blood vessel enhanced image representing a same cross section as the B mode image, and one or more front images individually formed based on a three dimensional data set acquired by performing optical coherence tomography on a subject's eye in a predetermined layout. Further, the display controller displays a cross section position indicator that indicates a position of a cross section of the B mode image over at least one of the one or more front images. In addition, the display controller synchronously performs changing of a display position of the cross section position indicator and updating of a display of each of the B mode image and the blood vessel enhanced image in accordance with an operation for moving the cross section position indicator performed using an operation unit.
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公开(公告)号：US10145669B2
公开(公告)日：2018-12-04
申请号：US15319360
申请日：2015-06-16
发明人： Jun Cheng , Jiang Liu , Lixin Duan , Yanwu Xu , Wing Kee Damon Wong , Masahiro Akiba
摘要： A method and system are proposed to obtain a reduced speckle noise image of a subject from optical coherence tomography (OCT) image data of the subject. The cross sectional images each comprise a plurality of scan lines obtained by measuring the time delay of light reflected, in a depth direction, from optical interfaces within the subject. The method comprises two aligning steps. First the cross sectional images are aligned, then image patches of the aligned cross sectional images are aligned to form a set of aligned patches. An image matrix is then formed from the aligned patches; and matrix completion is applied to the image matrix to obtain a reduced speckle noise image of the subject.
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公开(公告)号：US20170347880A1
公开(公告)日：2017-12-07
申请号：US15536461
申请日：2015-11-02
发明人： Masahiro Akiba
CPC分类号： A61B3/12 , A61B3/102 , A61B3/117 , A61B3/14 , A61B5/0066 , A61B5/0261 , G01N21/17
摘要： In an embodiment, a controller included in a blood flow measurement apparatus controls a scanner to iteratively scan one or more cross sections of an interested blood vessel. An image forming unit forms a phase image that represents chronological change in phase difference in the one or more cross sections based on data acquired through iterative scan. An image processor outputs a predetermined signal based on the chronological change in phase difference represented by the phase image. Upon receiving the predetermined signal, the controller controls the scanner to start scan for acquiring blood flow information on the interested blood vessel.
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公开(公告)号：US20170347879A1
公开(公告)日：2017-12-07
申请号：US15536359
申请日：2015-11-02
发明人： Masahiro Akiba
CPC分类号： A61B3/12 , A61B3/0025 , A61B3/102 , A61B5/0066 , A61B5/0261 , G01N21/17
摘要： A scanner of a blood flow measurement apparatus of an embodiment alternately performs first scan and second scan for first and second cross sections both intersecting an interested blood vessel. An image forming unit forms one or more images of the first cross section including a phase image of the first cross section and an image of the second cross section. A blood vessel region specification unit specifies a first blood vessel region in any of the one or more images of the first cross section and a second blood vessel region in the image of the second cross section. A gradient calculation unit calculates a gradient of the interested blood vessel at the first cross section based on the first and second blood vessel regions. A blood flow information generation unit generates blood flow information based on the phase image and the gradient.
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9.发明授权Optical image measuring apparatus, image displaying apparatus and image displaying method 有权光学图像测量装置，图像显示装置和图像显示方法公开(公告)号：US09492082B2
公开(公告)日：2016-11-15
申请号：US14379623
申请日：2013-03-08
发明人： Akitoshi Yoshida , Masahiro Akiba , Yasufumi Fukuma , Hideaki Tokoro , Taiki Aimi , Shunsuke Nakamura
CPC分类号： A61B3/1233 , A61B3/102 , A61B3/1241 , A61B5/0066 , A61B5/026 , A61B5/0261 , A61B5/0285 , A61B5/489 , A61B5/6821 , A61B5/7278 , A61B5/742 , A61B5/743 , G01N21/4795 , G06F19/00 , G06T11/60 , G06T2210/41
摘要： An optical system splits light into signal light and reference light and detects interference light between scattered light of signal light from living body and reference light. A scanner performs first scan in which first cross section that intersects interested blood vessel is repeatedly scanned with signal light. An image forming part forms first cross sectional image expressing chronological variation of morphology of first cross section and phase image expressing chronological variation of phase difference based on detection results of interference light acquired during first scan. A blood vessel region specifying part specifies blood vessel region corresponding to interested blood vessel for first cross sectional image and phase image. A blood flow information generator generates blood flow information related to interested blood vessel based on blood vessel region of first cross sectional image and chronological variation of phase difference within blood vessel region of phase image.
摘要翻译： 光学系统将光分解为信号光和参考光，并检测来自活体的信号光和参考光的散射光之间的干涉光。 扫描仪执行第一次扫描，其中与感兴趣的血管相交的第一横截面用信号灯重复扫描。 图像形成部分基于第一扫描期间获得的干涉光的检测结果，形成表示第一横截面的形态的时间变化和表示相位差的时间变化的相位图像的第一横截面图像。 血管区域指定部指定与感兴趣的血管对应的第一横断面图像和相位图像的血管区域。 血流信息发生器根据第一截面图像的血管区域和相位图像的血管区域内的相位差的时间变化产生与感兴趣的血管相关的血流信息。
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公开(公告)号：US10905323B2
公开(公告)日：2021-02-02
申请号：US15536359
申请日：2015-11-02
发明人： Masahiro Akiba
摘要： A scanner of a blood flow measurement apparatus of an embodiment alternately performs first scan and second scan for first and second cross sections both intersecting an interested blood vessel. An image forming unit forms one or more images of the first cross section including a phase image of the first cross section and an image of the second cross section. A blood vessel region specification unit specifies a first blood vessel region in any of the one or more images of the first cross section and a second blood vessel region in the image of the second cross section. A gradient calculation unit calculates a gradient of the interested blood vessel at the first cross section based on the first and second blood vessel regions. A blood flow information generation unit generates blood flow information based on the phase image and the gradient.
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