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公开(公告)号：US20170145466A1
公开(公告)日：2017-05-25
申请号：US15323144
申请日：2015-07-02
Applicant: KANEKA CORPORATION
Inventor： Masutoshi NOJIRI , Yoshihiko YASOHARA
IPC: C12P21/02
Abstract: The technical problem to be solved by the present invention is to provide a method for producing oxidized glutathione, GSSG and a precursor thereof, i.e., oxidized γ-glutamylcysteine, by a simple process. As a means for solving the problem, the method for producing GSSG according to the present invention comprises step A′ of reacting L-cystine and L-glutamic acid to produce oxidized γ-glutamylcysteine and step B′ of reacting oxidized γ-glutamylcysteine and glycine to produce GSSG.
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公开(公告)号：US20130079525A1
公开(公告)日：2013-03-28
申请号：US13682840
申请日：2012-11-21
Applicant: KANEKA CORPORATION
Inventor： Kohei MORI , Masutoshi NOJIRI , Akira NISHIYAMA , Naoaki TAOKA
IPC: C07D211/56 , C07D211/60
CPC classification number: C07D211/60 , C07B57/00 , C07D211/56 , C12P17/12 , C12P41/006
Abstract: The present invention relates to a method for producing an optically active 3-aminopiperidine or salt thereof. In the method, a racemic nipecotamide is stereoselectively hydrolyzed to obtain an optically active nipecotamide and an optically active nipecotic acid in the presence of an enzyme source derived from an organism, and then the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by aroylation, Hofmann rearrangement, deprotection of the amino group and further deprotection; or the optically active nipecotamide is derived into an optically active aminopiperidine or salt thereof by selective protection with BOC, Hofmann rearrangement and further deprotection. It is possible by the present invention to produce an optically active 3-aminopiperidine or salt thereof useful as a pharmaceutical intermediate from an inexpensive and easily available starting material by easy method applicable to industrial manufacturing.
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公开(公告)号：US20200010814A1
公开(公告)日：2020-01-09
申请号：US16584734
申请日：2019-09-26
Applicant: KANEKA CORPORATION , Kyoto University
Inventor： Masutoshi NOJIRI , Yoshihiko YASOHARA , Makoto HIBI , Jun OGAWA
Abstract: An enzyme protein that allows production of an optically active β-hydroxyamino acid, specifically a monooxygenase having two kinds of hetero (different) subunits. Also, systems and methods using the monooxygenases.
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公开(公告)号：US20170211117A1
公开(公告)日：2017-07-27
申请号：US15325891
申请日：2015-07-28
Applicant: KANEKA CORPORATION
Inventor： Masutoshi NOJIRI , Yoshihiko YASOHARA
CPC classification number: C12P21/02 , C12N9/00 , C12N9/1229 , C12N9/93 , C12P19/32 , C12Y207/04 , C12Y603/02002 , C12Y603/02003
Abstract: The technical problem to be solved by the present invention is to provide a method for producing glutathione and a precursor thereof, γ-glutamylcysteine, at a high yield. As a means for solving the problem, the method for producing glutathione according to the present invention includes step A′ of reacting L-cysteine and L-glutamic acid under a low-oxygen atmosphere to produce γ-glutamylcysteine and step B′ of reacting γ-glutamylcysteine and glycine under a low-oxygen atmosphere to produce glutathione.
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