公开(公告)号：US20160250314A1

公开(公告)日：2016-09-01

申请号：US15052594

申请日：2016-02-24

Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Sanjeev NARAYANAN ,  Amit KUMAR ,  Tiruvoor NAGARAJA ,  Muckatira CHENGAPPA

IPC: A61K39/114

CPC classification number: A61K39/114 ,  A61K39/39 ,  C07K14/195

Abstract: The present invention relates to protecting against, treating, and detecting Fusobacteria infections. Compositions and methods derived from nucleic acid and protein sequences of a 40 kDa Adhesin protein are provided to protect against, treat, and detect Fusobacteria infections in a subject. In one aspect, vaccines capable of inducing an immune response to a 40 kDa Adhesin protein are used to protect against Fusobacteria infection. Also, nucleic acid molecules, proteins, immunogens, antibodies, and antisense molecules derived from the sequences of the 40 kDa Adhesin protein may be used to protect against, treat, and detect Fusobacteria infections in a subject.

Abstract translation: 本发明涉及防止，治疗和检测Fusobacteria感染。 提供衍生自40kDa粘合素蛋白质的核酸和蛋白质序列的组合物和方法以保护受试者中的Fusobacteria感染免受，治疗和检测。 在一个方面，能够诱导对40kDa粘附素蛋白质的免疫应答的疫苗用于保护免受细菌感染。 此外，衍生自40kDa粘附蛋白序列的核酸分子，蛋白质，免疫原，抗体和反义分子可用于保护受试者中的Fusobacteria感染免受，治疗和检测。

公开(公告)号：US20180243396A1

公开(公告)日：2018-08-30

申请号：US15961996

申请日：2018-04-25

Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Sanjeev NARAYANAN ,  Amit KUMAR ,  Tiruvoor NAGARAJA ,  Muckatira CHENGAPPA

IPC: A61K39/114 ,  C07K14/195 ,  A61K39/39

CPC classification number: A61K39/114 ,  A61K39/39 ,  C07K14/195

Abstract: The present invention relates to protecting against, treating, and detecting Fusobacteria infections. Compositions and methods derived from nucleic acid and protein sequences of a 40 kDa Adhesin protein are provided to protect against, treat, and detect Fusobacteria infections in a subject. In one aspect, vaccines capable of inducing an immune response to a 40 kDa Adhesin protein are used to protect against Fusobacteria infection. Also, nucleic acid molecules, proteins, immunogens, antibodies, and antisense molecules derived from the sequences of the 40 kDa Adhesin protein may be used to protect against, treat, and detect Fusobacteria infections in a subject.

公开(公告)号：US20180071382A1

公开(公告)日：2018-03-15

申请号：US15824694

申请日：2017-11-28

Applicant: KANSAS STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Sanjeev NARAYANAN ,  Amit KUMAR ,  Tiruvoor NAGARAJA ,  Muckatira CHENGAPPA

IPC: A61K39/114 ,  A61K39/39 ,  C07K14/195

CPC classification number: A61K39/114 ,  A61K39/39 ,  C07K14/195

Abstract: The present invention relates to protecting against, treating, and detecting Fusobacteria infections. Compositions and methods derived from nucleic acid and protein sequences of a 40 kDa Adhesin protein are provided to protect against, treat, and detect Fusobacteria infections in a subject. In one aspect, vaccines capable of inducing an immune response to a 40 kDa Adhesin protein are used to protect against Fusobacteria infection. Also, nucleic acid molecules, proteins, immunogens, antibodies, and antisense molecules derived from the sequences of the 40 kDa Adhesin protein may be used to protect against, treat, and detect Fusobacteria infections in a subject.